Assistant Professor https://xitter.cf/t.co/C1RcAPDAyY @foxchasecancer @CeiFccc studying RNA biology in diseases; trainings @ScienceStowers and @Stanford.

KC-Stanford-Philly
Joined July 2009
Our paper made it to the cover art of current NAR: we revealed a crosstalk between 5′ cap methylation & 3′ processing of snRNAs essential to motor neuron survival in 4 organisms. These cutesy snakes are indebted to the only @DrawImpacts @FoxChaseCancer academic.oup.com/nar/issue/5…
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Putting a room of smart people together, amazing things will happen. The prophecy is realizing day by day. So thankful for this lovely group. luchenlab.org @CeiFccc @FoxChaseCancer Happy holiday season.
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Elizabeth "Liz" Brown, our undergrad @VillanovaU, and Gregory "Greg" Matveev, our master student from @mipt_eng @CeiFccc just won their respective Best Poster award in the 28th Annual Research Day @FoxChaseCancer. Liz and Greg's work on basic biology of sarcoma and its mechanism in therapy resistance has received early recognition - the sky is the only limit for Liz and Greg. Congrats!
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PALB2 and 53BP1 govern post-resection homologous recombination DNA repair dlvr.it/TMNXKt
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wow, are we just stepped into a new era in human history?
In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by @US_FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe, rapidly progressing genetic disease... all in an astounding 7 months. Best of all, the infant patient shows apparent benefit. Congratulations to @kiranmusunuru, Rebecca Ahrens-Nicklas, and other team members for this heroic and inspiring effort, which has implications for the hundreds of millions of patients that suffer from thousands of genetic diseases. drive.google.com/file/d/1Jfk…
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LuChenLab of @FoxChaseCancer @CeiFccc making noises at the 2025 Cold Spring Harbor meeting @cshlmeetings #cshltelo - satisfying to see Greg and Alex' work receiving wider recognition and feedback and them thriving in the incredible soil of @CSHL
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Our review epub @CSHLPress. Great ride led by Luis Batista @WashUHematology & by @CeiFccc @FoxChaseCancer contributing to an understanding of telomerase RNP - the immortality enzyme hijacked by 85% cancers and the untapped "fountain of youth" for aging diseases. pubmed.ncbi.nlm.nih.gov/4021… – at Philadelphia, PA
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What a triumphant and compassionate moment for science. What a speech by the patient and @davidrliu and this is truly a moment that transcends life.
Last night I was honored to receive the 2025 #BreakthroughPrize in the Life Sciences, reflecting the efforts of many students, collaborators, doctors, and patients in labs around the world. I hope this 4-minute excerpt can inspire when science needs public support more than ever.
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Pleasure to host Prof. Allen Nicholson from @TempleUniv with @DNAmyWhitaker @RolandDunbrack and Sid Balachandran for a super clarifying seminar and productive visit today at @FoxChaseCancer. Audience questions kept sprinkling in throughout Allen's seminar and it got extended 30min longer as the Q&A seemingly kept going forever. Incredibly satisfying to appreciate the power of clean controls, direct, rigor, and interpretable data. What a day of bridge building between faculty and trainees across campuses @TempleOwls. #scienceprevails
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Gregory Matveev, our star master student, has been selected for a podium talk in the upcoming telomere/telomerase meeting at the Cold Spring Harbor Laboratory @CSHL- a rare golden opportunity for trainees. Here is Greg presenting his work to @CeiFccc @FoxChaseCancer. He is excited to face the toughest audience possible and receive valuable feedback for his discovery on telomerase. #cshltelo
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Our star high school scholar Arushi Vignesh won the 1st place in the Chester County Science Fair 2025, with her work "Visualizing the Activity of Telomerase in ALT Cells". @CeiFccc @FoxChaseCancer @teschools Arushi is a rising college freshman, coming to us from Conestoga High School, Berwyn PA - such a pleasure to witness the birth of a new star.
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Excited to see Grigory discuss his research in @luchenlab_FCCC @CeiFccc @FoxChaseCancer in the #NuclearDynamicsCancerProgram Super to see trainees lead program meetings at our @theNCI Designated Center.
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#CEI2025Symp @CeiFccc @FoxChaseCancer presents key awards- 1. @institut_curie & @CeiFccc #Epigenetics Course awardees 2. C. David Allis Travel Awards- congrats to the 7 winners, especially our lab member Chloe! 3. Mentor awardee- @luchenlab_FCCC
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Pround of our stellar graduate student Alex Morris @TempleUniv @CeiFccc @FoxChaseCancer presenting part of his thesis work in #cei2025symp.
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Science is under threat.
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NIH-supported basic biomedical research is the ROOTs of the tree of the biopharmaceutical industry (lifesaving while in trillion$). With the late Friday evening tweet by @NIH, the entire root system is being severed to its core, and there won't be leaves, flowers, or any fruits to bear- savable Lives will be lost, generations of talents, progress, and knowledge in cancer, aging, heart and neuronal diseases will be drained.
It's not "breaking news" now, since it was announced by NIH yesterday. But it is breaking....... washingtonpost.com/health/20…
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The indiscriminate and ill-conceived slashing of indirects by the @NIH yesterday must be amended if want to restore America’s leadership role biomedical research. 15% simply isn’t enough for institutions to provide the basic infrastructure needed to run a successful lab. I say this as someone who has been and remains deeply critical of the NIH, its funding system and of the ways universities are structured and spend money. We would all benefit from a genuine reexamination of how and to what @NIH funds are allocated, and I remain optimistic that once the dust settles and new NIH leadership is in place that this is what will happen and this hack job by people who don’t understand or care about research will be forgotten. And I’m sorry but I can’t help but laugh at the people who are demanding a full-throated defense of the current indirect levels. Nearly every PI I’ve known for my entire career has complained about excessive indirect rates. This is mostly because, despite their importance, even most PIs haven’t bothered to actually understand them, and because they don’t FEEL that universities are actually spending the money to support their research. Whether they are or not nobody really knows because in the typically Byzantine maze of university budgets it’s often very hard to figure out. There are also lots of actual shenanigans that go on especially at places with the highest indirect rates to use funds to build out the institution and increase its power rather than to directly support funded research projects. And anyone who says administrative bloat at universities isn’t real and partially fueled by indirects is either blind or part of the bloat. So let’s get organized to have an actual constructive response to this firebomb. Scientists need to advocate for what is best for research - and we have to do it ourselves because the institutions that claim to represent us - universities and scientific societies in particular - have their own goals that often do not align with ours. We also have to remember that grants are not an entitlement. We are not owed anything. If we want to continue benefiting from the public support we have always enjoyed, we have to show the public and their representatives - even ones we might not always agree with - that we’re spending their money wisely.
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We are pleased to announce registration for RNA 2025 - the 30th Annual Meeting of the RNA Society - is now open! www2.rnasociety.org This year’s meeting will be held at the beautiful Town and Country Resort & Convention Center in sunny San Diego, California, USA from May 27th - June 1st, 2025.
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Social DNAing has been a super-productive forum - our presentation has since received great numbers of helpful feedbacks and interactions from the nucleic acids and molecular condensate communities. Thanks @zha_lab, Jaewon Min and Jean Gautier @Columbia, for hosting and the opportunity.
Thank the rising stars for outstanding webinars. This week, Dr. Lu Chen will join Social DNAing to discuss aging-associated chromatin changes. Please sign up at cancer.columbia.edu/research…
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Alexander D. Morris, our one and only cell-to-peak/dry-wet combo, escalated to PhD candidacy status @templemedschool in Jan 2025 - a much-desired turn of a new page and hopefully a strong momentum for new milestones soon to follow @FoxChaseCancer @CeiFccc #proudPI #NextGenPI 🥳👍
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