@LuptonCJ

Postdoc @MonashUni @MonashBDI - Structural biology - CryoEM - MicroED

 Melbourne, Victoria
Joined February 2014
  • Tweets138
  • Following440
  • Followers258
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Thrilled to see our work out in @Nature on the #cryoem structure of LYCHOS! A monumental effort from co-first author @bj_charles, the @Dr_Ellisdon Lab, the @Dr_MLHalls Lab from @MIPS_DDB, @HariVenugopal2 from @CryoEM_Monash. nature.com/articles/s41586-0…

LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR

Nature - Cryo-electron microscopy structures of the human lysosomal transmembrane protein LYCHOS show that it comprises a transporter-like domain fused to a G-protein-coupled receptor, and that the...

nature.com
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Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex #science #publication #research #journal lifescience.net/entries/8292…

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex

Latest journal content in life sciences. Journal sponsorship available to publishers.

lifescience.net
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Absolutely thrilled to see our latest study online @CellCellPress. Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex. doi.org/10.1016/j.cell.2025.… @LuptonCJ @Dr_MLHalls & Andrew Ellisdon. #cryoEM #KICSTOR #mTORC1 #GATOR1
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🍃➡️🧬 First paper from the Martynowycz Lab! Spontaneous seed-protein nanocrystals → 0.85Å ab-initio structure of crambin by #MicroED No crystallization screens, no MR bias. Watch the diffraction-to-density movie & grab the preprint below! biorxiv.org/content/10.1101/…
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Excited to share the N&V @RobertoZoncu and I wrote for @NatureSMB on the recent surge of LYCHOS structure papers! 🚀 We propose a unifying model that ties together these new discoveries. It’s incredible to see so much momentum building on our work. nature.com/articles/s41594-0…

Cholesterol finds its pocket in LYCHOS

Nature Structural & Molecular Biology - The lysosomal transmembrane protein LYCHOS enables activation of the master growth regulator mTORC1 kinase by cholesterol. Here we summarize recent...

nature.com
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Amidst the chaos, here's a belated but exciting highlight on the recent LYCHOS structure by @bj_charles @LuptonCJ @Dr_Ellisdon @Dr_MLHalls @RobertoZoncu and I broke down their findings, explored future directions, and tackled the key remaining questions. authors.elsevier.com/c/1kZRC…
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We are hiring! The Formosa Group is hiring a Research Officer to join our program on #Mitochondria, #Metabolism & #MitochondrialDisease @MonashBDI! 💡If you're passionate about mitochondrial research or know someone who is, please share! Apply now: careers.pageuppeople.com/513…
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🚨 Save the Date! 🚨 I'm thrilled to announce the Prato Conference on Pore Forming Proteins, happening this June in the stunning city of Prato, Italy! 🙏 Please share or repost this to help us reach as many people as possible—especially those who would love to attend!
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Chris Lupton retweeted
Evan Healy@evan_healy414 Jan 2025
🧵 1/ We’re excited to share that our new paper with @adrianbracken lab is out 🎉 In this study (which began 10 years ago!) we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇
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Thrilled to see our work on high-resolution #cryoem using a common LaB6 120-keV TEM and sub–200-keV direct electron detector, now online @ScienceAdvances. science.org/doi/10.1126/scia… . A collaboration with @GatanMicroscopy, @GeorgRamm, and @CryoEM_Monash.
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Update! We outline AIVE, an AI method for volume EM data. We show the benefits of AIVE for reconstructing your FIB-SEM data, reveal some fascinating cell biology, and define intrusions as a new form of mitochondrial contact. biorxiv.org/content/10.1101/… Muscle mito nanotunnels 1/3🧵
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Great to see our work on the #cryoem structure of the human TSC:WIPI3 lysosomal recruitment complex in @ScienceAdvances! Awesome effort from co-authors @bj_charles and @sci_laura with @Dr_Ellisdon doing the heavy lifting leading the project. science.org/doi/10.1126/scia…

Structure of the human TSC:WIPI3 lysosomal recruitment complex

The complete TSC structure reveals how lysosomal targeting proteins and phosphoinositides coordinate mTORC1 inhibition.

science.org
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🚨 Our story on the TSC:WIPI3 lysosomal-recruitment complex is now live in @ScienceAdvances . Equal-first co-authors @LuptonCJ & @sci_laura. Work lead by @Dr_Ellisdon. Funding from @DeptofDefense & @arc_gov_au. science.org/doi/10.1126/scia…
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Highlighted today in @CellCellPress a great perspective piece about our recent work on LYCHOS. @arshukla and colleagues raise interesting points about membrane cross talk! cell.com/cell/abstract/S0092…
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Chris Lupton retweeted
Arun K. Shukla@arshukla14 Nov 2024
Delighted to share our preview article now published in Cell @CellCellPress where we highlight the beautiful LYCHOS story from @Dr_Ellisdon and team, published recently in @Nature! Bound by the love for cholesterol: A transporter meets a GPCR: Cell cell.com/cell/fulltext/S0092…
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Chris Lupton retweeted
nature
@Nature4 Oct 2024
Nature research paper: LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR go.nature.com/3zKOh3i

LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR

Nature - Cryo-electron microscopy structures of the human lysosomal transmembrane protein LYCHOS show that it comprises a transporter-like domain fused to a G-protein-coupled receptor, and that the...

nature.com
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👇Read on to find out about a fascinating #GPCR acting as a domain of a larger transmembrane protein at the lysosome, important for regulation of #mTOR A wonderful collaboration with @Dr_Ellisdon between @MIPS_DDB @MIPS_Australia and @MonashBDI, and a huge effort from our teams
Charles Bayly-Jones@bj_charles2 Oct 2024
We are thrilled beyond words to see our LYCHOS (GPR155) publication out today in @Nature. 🥳 “LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR” nature.com/articles/s41586-0… 🧵

LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR

Nature - Cryo-electron microscopy structures of the human lysosomal transmembrane protein LYCHOS show that it comprises a transporter-like domain fused to a G-protein-coupled receptor, and that the...

nature.com
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So great to see the fantastic, world-leading science of talented ECRs @MonashBDI & being recognised - both in @Nature & in @theage. Supporting the next generation of scientific talent in Australia is vital 💪 🔗The Age story (behind paywall): bit.ly/4gS53y4
Monash Biomedicine Discovery Institute@MonashBDI2 Oct 2024
1/Paving the way for possible new treatments of diseases triggered by abnormal cell growth,research published in @Nature, co-led by BDI's @Dr_Ellisdon & @MIPS_Australia @dr_MLHalls, co-first @BJ_Charles @luptoncj, has solved the structure of ‘LYCHOS’. More bit.ly/3XQ9EIl
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Many thanks to @MonashUni, @MonashBDI, @MIPS_Australia @Monash_FMNHS for the support
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Spectacular cryoEM structure of LYCHOS by @bj_charles & team out in @nature strongly supports its role as cholesterol sensor for mTORC1 that we (@HijaiShin) discovered, and points to an intriguing mechanism of transport-coupled cholesterol binding. Congratulations!
Charles Bayly-Jones@bj_charles2 Oct 2024
We are thrilled beyond words to see our LYCHOS (GPR155) publication out today in @Nature. 🥳 “LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR” nature.com/articles/s41586-0… 🧵

LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR

Nature - Cryo-electron microscopy structures of the human lysosomal transmembrane protein LYCHOS show that it comprises a transporter-like domain fused to a G-protein-coupled receptor, and that the...

nature.com
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