@macara_ian

Professor and Chair of the Department of Cell and Developmental Biology at Vanderbilt University. We study cancer, stem cells, cell polarity and epithelia.

Joined August 2018
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Check out this video of knock-in ZO1 tagged with StayGold - incredible stability and brightness!! (continuous laser for 1 hour!)
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A junction-dependent mechanism drives murine mammary cell intercalation for ductal elongation - now available online from Developmental Cell! Congrats to Alex on a great paper!!
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Exciting speakers at our 2023 cell dynamics symposium! - this May 18-19
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Congratulations to Lindsey Seldin on her appointment as an Assistant Professor in Cell Biology at Emory University! We will all miss her here at Vanderbilt.
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Interested in epithelial cells? In stem cells? - the Macara lab is looking for talented postdocs for projects on embryonic stem cell differentiation, and on mammary gland development, breast cancer and cell fate plasticity. CRISPR, high-end microscopy, mouse models, 3D organoids
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Look at this heron using bread as fishing bait ...
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Great results with Luke Lavis's JF552-SNAPcp dye! Trying to make a SNAP knock-in of the Pals1 polarity protein. SNAP dyes are notoriously bad for nonspecific labeling of cells. But the new JF552 Lavis dye is not fluorescent until bound to the SNAP tag protein - works super well!
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Our Cell and Developmental Biology faculty search at Vanderbilt has now gone live! Applications will be through Interfolio at the following link: apply.interfolio.com/93555 Ads will be posted online with Nature, Science and Cell.
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The Dept of Cell and Developmental Biology at Vanderbilt is beginning a search for new junior faculty this fall. This is an open search - looking for exceptional scientists in any area of cell/dev biology.
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Check out our new BioRxv preprint - "A self-limiting circuit regulates mammary cap cell plasticity through TGF-beta signaling" by Armelle Le Guelte. Cool story!
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Hey, check out our recent Vanderbilt Lab-toTable Webinar discussion on the origins of life! - youtube.com/watch?v=DziXzCAO… I moderate a discussion with an astronomer, theologian and a philosopher about life in the universe, the origin of life, and other interesting questions
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Exciting discovery about pluripotent stem cells! Check out Loic's new preprint on BioRxiv at: biorxiv.org/content/10.1101/…

Apoptotic Find-me Signals are an Essential Driver of Stem Cell Conversion To The Cardiac Lineage

Pluripotent stem cells can be driven by manipulation of Wnt signaling through a series of states similar to those that occur during early embryonic development, transitioning from an epithelial...

biorxiv.org
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Dancing molecules! - Crumbs3-Halotag at cell junctions. You can see individual molecules interacting! - in a living cell!
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Looking for new postdocs to work on several exciting projects on iPSCs, stem cell plasticity (Dev Cell 2020) and early events in cancer (eLife 2020). Contact me at: [email protected]
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Interested in cancer research and epithelial cell biology?- join the Macara lab as a postdoc! We have projects on ESCs, mammary and skin stem cells, breast cancer, genome-wide CRISPR screens, and single molecule imaging. Contact: [email protected]
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