Pickle juice apparently saves the day after Carlos Alcaraz suffers from cramp at the Australian Open, requiring a medical time out and threatening an early exit. His rapid recovery and heroic comeback was attributed to pickle juice which promptly relieved his cramp. Made from a concoction of water, vinegar, salt and spice, pickle juice has become a popular choice for remedying cramps in athletes, and in patients suffering from cramp. A randomised trial of cirrhotic patients, coined the PICCLES study, concluded that sips of pickle juice consumed at cramp onset improves cramp severity without adverse events. It is thought that the acetic acid of pickle juice acts as an agonist of sensory Transient Receptor Potential (TRP) channels and foregut Acid Sensing Ion Channels (ASIC), triggering nerve conduction in the oropharynx that aborts the cramp without changing serum electrolytes, and doing so faster and more effectively than water alone. Perhaps one to add to our toolbox for people suffering from cramp 🥒🥤