@matemanc

Computational immunologist focusing on #HLA in #infectious, #autoimmune diseases and #cancer. #immunology #immune #tumor #MHC #bioinformatics #immunotherapy

 Szeged, Hungary
immunoinfo.hu
Joined December 2013
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I C U mutant! Our new paper is out! Our immune system doesn’t just fight viruses – it edits them. APOBEC enzymes introduce C>U mutations that often make viral proteins easier for HLA molecules and T-cells to detect, boosting immune recognition. nature.com/articles/s41467-0… #COVID_19
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1/3 🧬 Our review is out in @NatureRevMicro! How can we develop #antibiotics that remain effective as bacteria evolve? Our answer: make #resistance evolution part of drug development from the very beginning.
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Mate Manczinger retweeted
Csaba Pal Laboratory@Csaba_Pal_LabOct 6
📢 Paper Alert! Grateful to have been involved in this amazing work by @research_lazar and SzilviaJuhasz labs, presenting a framework for dissecting pathogen-host-drug interactions. #Pathogen #Virulence #SingleCell #DeepLearning @SysbioS Check it at: shorturl.at/LQUFP 👇

Deep-learning single-cell profiling uncovers interbacterial and drug-driven reshaping of pathogen...

Nature Communications - This study introduces MALVINA, a deep-learning platform that measures bacterial invasion and DNA damage in individual human cells, revealing how bacterial interactions and...

nature.com
TheLazarLab@research_lazarOct 5
Counting bacteria is not enough. To understand what makes a bacterium dangerous, we need to see what it actually does when it meets human cells. Our MALVINA study is now out in @NatureComms
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The story is not simply “broader is always better”. Broad HLA-II presentation may help against common pathogens, while more selective HLA-II variants may be advantageous in specific contexts, such as HIV. Full text: nature.com/articles/s41467-0… @matemanc

HLA-II peptide-binding diversity shapes humoral immune responses and susceptibility to infections

Nature Communications - Human leukocyte antigen class II (HLA-II) are involved in the presentation of peptides to helper T cells which guide in the B cell response and antibody production. Here...

nature.com
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Individuals can carry different variants of HLA genes. Some HLA variants bind a broad range of peptide sequences, whereas others are more selective. Is this variation associated with susceptibility to infection? nature.com/articles/s41467-0…

HLA-II peptide-binding diversity shapes humoral immune responses and susceptibility to infections

Nature Communications - Human leukocyte antigen class II (HLA-II) are involved in the presentation of peptides to helper T cells which guide in the B cell response and antibody production. Here...

nature.com
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Moreover, HLA variants with broader peptide-binding specificity are also associated with stronger antibody responses following influenza vaccination. Check out our article to learn more!
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It was a wonderful collaboration with Thomas Vogl at Medical University of Vienna and @SashaZhernakova at @univgroningen I am also grateful to my research group @BiologicalRese1 immunoinfo.hu
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Mate Manczinger retweeted
BalintKintsesLab@KintsesLabJul 20
New paper out in @NatureComms We usually think of bacteriophages as viruses that interact exclusively with bacteria. Our work suggests the story is more complex: communities.springernature.c… We’d love your thoughts! @ApjokGabor #phages #microbiome #virome

Searching for the human-facing side of the virome

It all began with a simple question: if phages are so abundant in the human gut, do some of them physically interact with our own cells? We expected rare exceptions. Instead, we found adhesins...

communities.springernature.com
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Balazs Papp lab@balazs_papp_labJun 15
Can harmful gene loss become an evolutionary opportunity? In our new work in @OfficialSMBE, lab-evolved E. coli lines recovering from metabolic gene loss did more than return to normal: some surpassed wild-type on nutrients never seen during lab evolution. doi.org/10.1093/molbev/msag1…
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Eric Topol
@EricTopolJun 2
Big progress vs cancer, folks. The kind of event curves from randomized trials that we've not seen before for a couple of the most deadly cancers. Congrats to the oncology research community for getting these trial done. #ASCO26, @ASCO
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A brief summary of our recent paper: "Five mutational “fingerprints” could help predict how visible tumours are to the immune system" eurekalert.org/news-releases… Link to our paper: link.springer.com/article/10… #Cancer #CancerResearch #Science

Five mutational “fingerprints” could help predict how visible tumours are to the immune system

Researchers from the HUN-REN Szeged Biological Research Centre and HCEMM have just published a new study suggesting that it’s not simply the number of tumour mutations that matters for immunotherapy,...

eurekalert.org
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Mate Manczinger retweeted
HCEMM@HcemmSzegedFeb 5
Read the summary of our latest publication: Five mutational “fingerprints” could help predict how visible tumours are to the immune system, via @EurekAlert! eurekalert.org/news-releases…

Five mutational “fingerprints” could help predict how visible tumours are to the immune system

Researchers from the HUN-REN Szeged Biological Research Centre and HCEMM have just published a new study suggesting that it’s not simply the number of tumour mutations that matters for immunotherapy,...

eurekalert.org
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Mate Manczinger retweeted
Caleb Lareau
@CalebLareauJan 28
⚠️ If you’re reading this, you’ve been infected* ⚠️ *~95% the human population has been infected by the Epstein-Barr Virus (EBV). Today in @Nature with @nyeo_sherry, @EMC22381830, @RyanDhindsa @SlavePetrovski, we shed some light on what happens next. nature.com/articles/s41586-0…

Population-scale sequencing resolves determinants of persistent EBV DNA

Nature - Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence...

nature.com
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Our new paper is out: Five dominant amino acid substitution signatures shape tumour immunity link.springer.com/article/10… Thread 🧵⬇ #CancerResearch #cancer #tumor #immunesystem #Science #sciencenews

Five dominant amino acid substitution signatures shape tumour immunity

Molecular Systems Biology - Although numerous mutational processes operate in cancer, their functional impacts are unclear. We hypothesised that certain mutation sources preferentially generate...

link.springer.com
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8/ But there’s nuance inside AAS4: Among AAS4-driven tumors, specific HLA variants are enriched in immune-hot cases. So antigen presentation genetics may modulate whether an AAS4 tumor ends up “cold” vs “hot.”
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9/ Takeaway: Protein-level mutation patterns provide a complementary lens to DNA mutational signatures—linking mutagenesis + repair defects to peptide properties, immune contexture, and therapy response.
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