Another exciting milestone in biocatalysis with nonheme enzymes! We have developed the first enzymatic system for copper-catalyzed radical C(sp³)–N coupling: science.org/doi/full/10.1126…, which also represents the first demonstration of employing pterin-dependent nonheme enzymes in non-natural reactions. This work was led by postdoctoral fellow Dr. Xuzhong Shen (@lanser1208 ), in collaboration with Prof. Yi Rao’s group at Utah State University, Prof. Yunfang Yang at Zhejiang University of Technology, and Dr. Marc Garcia-Borràs @MarcGBQ from the University of Girona. Once again, this study highlights the power of combining metal substitution with nonheme enzyme biocatalysis to push the boundaries of biocatalytic transition metal catalysis.