Research assistant professor at Albert Einstein College of Medicine. Biophysical studies on molecular motors.
Joined May 2016
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nature.com/articles/s41467-0…
Since preprint, the #CryoEM datasets were further processed with #Relion to separate kinesin dimers or coexisting conformations on microtubules. 3 of 20 structures (2.7-3.9 Å) below. @SosaLab4 @SEMC_NYSBC #kinesins #microtubules #biophysics #cellbiology
Our study to understand how kinesin-8 can have both motility and microtubule depolymerization activities came out!
7 #CryoEM structures @SosaLab4. Data collected @SEMC_NYSBC.
Collaboration with @AllinghamJohn lab, biochem & X-ray structure by Byron Hunter.
nature.com/articles/s41467-0…
Our study to understand how kinesin-8 can have both motility and microtubule depolymerization activities
7 #CryoEM structures @SosaLab4
Data collected @SEMC_NYSBC
Collaboration with @AllinghamJohn lab, biochem & X-ray structure by Byron Hunter
#microtubule
dlvr.it/SKrQYT
Matthieu Benoit retweeted
1/ Excited to share our work on how kinesin binding protein (KIFBP) regulates kinesin! TL;DR: KIFBP remodels the kinesin motor to inhibit microtubule-binding
Matthieu Benoit retweeted
We are very excited to share our latest work, the high-resolution cryo-EM structure of the ex vivo cortical #microtubules from human parasite #Toxoplasma gondii. This work is in collaboration with David Sibley lab and @alanbrownhms lab.
nature.com/articles/s41467-0…
Matthieu Benoit retweeted
Fascinating microtubule structures solved by sub-tomogram averaging using EMAN (@sludtke and Muyuan Chen), imaging in @chiulab, segmentation with Segger! Identified tubulin proteins in different arrangements along with other components biorxiv.org/content/10.1101/…
Matthieu Benoit retweeted
Another wonderful collaboration with @alanbrownhms and @DutcherLab. Here we put complementary data together to build the complete structure of two distinct radial spokes on doublet microtubule. It was also a great experience to coordinate with the Vale lab for paper submission.
It always amazes me the things that can bind microtubules - our structures of radial spokes bound to ciliary doublet microtubules nature.com/articles/s41594-0…
18 new #cryoEM structures of the kinesin molecular motor KIF14 reveal its translocation mechanism
@SosaLab4
biorxiv.org/cgi/content/shor…
Collaboration with Kwok lab. Data collected at @SEMC_NYSBC
#EinsteinMed #MTmotors #kinesins #microtubules #biophysics @cryoEM_Papers #cellbiology
Matthieu Benoit retweeted
First paper from my lab after entering a new field. Great collaboration with @alanbrownhms and @DutcherLab! In this paper we use high-resolution #cryoEM to identify 38 ciliary doublet associated proteins including 33 #microtubule inner proteins (#MIPs) 😎
cell.com/cell/fulltext/S0092…
Matthieu Benoit retweeted
Here is what molecular motors, kinesins in this example, actually do to microtubules as they walk on them. 😵
Want to know how microtubules can survive in real life ? Have a look at our recent investigation:
biorxiv.org/content/early/20…
@SamReckPeterson @christlet @Lblanchoin
Matthieu Benoit retweeted
Pre-print on our latest #PRC2 work, spearheaded by @vignesh_k757 and supported by many collaborators: Curtis Beck, @poepsel_lab, @malamenteau, Jennifer Kosmatka, Dan Toso at the #BACEM facility, and Marco Faini in the Aebersold Lab in Zurich. #cryoEM
xitter.cf/biorxivpreprint/status…
JARID2 and AEBP2 regulate PRC2 activity in the presence of H2A ubiquitination or other histone modifications biorxiv.org/cgi/content/shor… #bioRxiv
Matthieu Benoit retweeted
Pre-print on a novel bacterial nanocompartment by @Nichols_NTA (@SavageCatsOnly lab) and our very own @bjlafrance features a beautiful 2.2 Angstrom-resolution #cryoEM structure of the nanocompartment shell. Check it out!
biorxiv.org/content/10.1101/…
Matthieu Benoit retweeted
Inspiring papers from the Scheres and Stark labs showing the amazing potential of cryo-EM. At 1.2 A resolution, even densities for hydrogen atoms are visible! Congrats to @SjorsScheres, @RaduAricescu and Holger Stark. #journalclub
doi.org/10.1101/2020.05.22.1…
doi.org/10.1101/2020.05.21.1…
Matthieu Benoit retweeted
Sosa lab @EinsteinMed provides structural insights into kinesin-13 mediated microtubule depolymerisation.
go.nature.com/2HQuXoi
Matthieu Benoit retweeted
Leginon's Extended Image Shift Mode Increases the throughput for Single Particle Data Collection cell.com/biophysj/fulltext/S…
Matthieu Benoit retweeted
This Saturday (28 April), the #LHC operators successfully injected 1200 bunches of protons into the machine and collided them, formally marking the start of the LHC’s 2018 physics season: cern.ch/go/TXD9
@ALICEexperiment, @ATLASexperiment, @CMSexperiment, @LHCbExperiment
