MitoScientists

ALT Mitochondria in Health & Disease 1 Nov 26 In this edition -Stimulated protein degradation to promote mitochondrial function and neuronal survival (Chandrasekhar et al., Science). Activating the reductive-stress E3 ligase CUL2-FEM1B preserved mitochondrial function and neuronal survival in models of COX deficiency syndrome and Friedreich’s ataxia. -MCT1-dependent mitochondrial lactate import sustains cardiac metabolism (Cluntun et al., Nature). MCT1 sits in the inner mitochondrial membrane of cardiomyocytes and, with matrix LDHB, turns lactate into pyruvate and NADH to fuel the electron transport chain. -Respiration-deficient cells require pyruvate carboxylase to suppress asparagine auxotrophy (Cui et al., Nature Metabolism). Patient-derived thyroid tumour cells with high-heteroplasmy complex I mutation and low PC are sensitive to L-asparaginase.

ALT Mitochondria in Health and Disease, Issue 25 Oct 2026

ALT Mitochondria in Health and Disease Issue 18 Oct 2026 57 papers in this edition, grouped by theme.

ALT MitDis BiomedNews edition 111026. As always, thanks to @gavinmcstay2, @mitoscientist, @mitoworld_org, @mitoscientists, and all mito-friends!

ALT Mitochondria in Health and Disease 27 Sept 2026

ALT 4D spatiotemporal landscape of mitochondrial phenotypes across cellular states unlocked through representation learning

ALT Cardiomyocyte-intrinsic somatic mtDNA mutations induce an OXPHOS-dependent immune response and promote progressive heart failure

ALT A genetic switch involving EGR1 and EZH2 links aging and development across human tissues

ALT The pseudouridine synthase PUSL1 modifies U39 of mitochondrial tRNAs and is linked to human neurological phenotypes