Molecular Dimensions

Beckham et. al. at EMBL Hamburg used the Molecular Dimensions Morpheus screen to solve the ESX-5 type VII secretion system. The unique combination of flexible protein layers around the pore to allow large conformational plasticity. DOI: 10.1126/sciadv.abg9923 #structuralbiology

Using Molecular Dimensions SelenoMet Medium Complete, Lazaro et. all. from CRNS showed that the mL-GHD180 adopts a unique quaternary structure. The ACT-like and PAS-type domains indicate allosteric regulation. DOI: 10.1038/s42003-021-02222-x

A structural basis for the inhibition of malaria cFRS by a novel series of bicyclic azetidines was solved by Shamsa et. al. hubs.ly/H0HCKJn0 Read more here: #CalibreScientific #structurebiology #crystallisation #crystallisation

The Schiffer Lab at UMass Medical School are investigating direct acting antivirals including a non-covalent inhibitor ML188.  Using our PACT Premier screen: hubs.ly/H0HCjtX0 Read more about the research: hubs.ly/H0HCjtY0 #structuralbiology #crystallisation

Valle et. al. at UMR crystallised the Ebola methyltransferase domain of the 'large' L protein. Crystals were obtained after a hit on the Molecular Dimensions ProPlex screen. #CalibreScientific #structurebiology #crystallisation #crystallisation #ebola

Blum et. al at the Paul Scherrer insititute in Swizerland improved the refinement of protein nanocrystals by statistically correcting the dynamic electron scattering, read more here: hubs.ly/H0HzCvD0 #CalibreScientific #structurebiology #crystallisation #crystallisation

Using SelenoMet Base and medium, Abidi et. al. from CBRS examined the Bcs macrocomplex involved in biofilm secretion of pathogenetic enterobacteria. hubs.ly/H0HzCwS0 Complete Article Here: hubs.ly/H0HzCvr0 #structurebiology #crystallisation #crystallisation

Using the Pact premier screen, Kaczmarski et. al. demonstrated that remote mutations can reshape the global confirmation of cyclohexadienyl dehydratase, funnelling it into catalytically relevant conformations. doi: 10.1038/s41467-020-19695-9 hubs.ly/H0Dkh200

Cawood et. al. at University of Leeds used Morpheus buffers to stablise oligomers with covalently tethered small molecules using "post-translational chemical modification" doi: 10.1021/jacs.0c10629 Learn more about our buffer lines here:hubs.ly/H0DkkF60

Morpheus screens were used to crystallise α-cobratoxin bound with small peptides that inhibit toxicity by Lynagh et. al. at University of Bergen doi: 10.1021/acs.jmedchem.0c01202 Learn more about the Morpheus family of screens here: hubs.ly/H0Dkpkh0

Crystals of the SiaABC domain grown using the @molecularD JCSG+ and Morpheus screens helps researchers to better understand biofilm growth doi: 10.1371/journal.pone.0241019 Find out more about our screens here: hubs.ly/H0DkpkH0

Researchers at Sheffield crystallised the A component (SmhA) of a tripartite pore-forming toxin using @molecularD Screens: JCSG+, Pact premier, ProPlex and Morpheus doi: 10.1107/S2053230X20013862 #CalibreScientific Find out about all our screens here: hubs.ly/H0DjZ770

Rattlesnake venom neurotoxin structure investigated and reveal possible interactions with #CFTR found in #CysticFibrosis patients doi: 10.3390/molecules25225290 #CalibreScientific Learn about the MemGold used to create the crystal: hubs.ly/H0DkgXy0

Rodnin et. al. from @KUMedCenter examined the structure of Diptheria Toxin with crystal obtained using @molecularD drop crystallisation plates doi: 10.3390/toxins12110704 #Calibre Scientific Find all our plates here: hubs.ly/H0DjWqk0

Kozak et. al. from @emblderived diffraction quality N-glycosylated proteins from the GlycoDelete HEK293 cell line using the @molecularDMorpheus I screen doi: 10.1107/S2059798320013753 #CalibreScientific Find out more about our Morpheus screens here: hubs.ly/H0Dkpkt0

Using @molecularDM9 Minimal Media, Manav. et. al at @MRC_LMB investigated the inhibition of an archaeal CRISPR subunit by an anti-CRISPR protein doi: 10.1038/s41467-020-19847-x Find out about our media selection here: hubs.ly/H0DkkC50

Using @molecularDSelenoMet medium, colleagues Zhang, Bellini and Barford at the @MRC_LMB solved the crystal structure of Cenp-HIKHead-TW sub-module of the inner kinetochore CCAN complex doi: 10.1093/nar/gkaa772 Find more about our SelenoMet here: hubs.ly/H0DjZ550

Our #CryoEM c-flats were used by Huo et. al. hubs.ly/H0Bfj-R0 The paper published in Cell focuses on the destruction of the SARS-CoV-2 spike protein to neutralise the virus. Read more here: hubs.ly/H0Bfj-S0

Our #CryoEM c-flats were used by Chen et. al. hubs.ly/H0Bf8CQ0 The Cell article features a unique look into the SARS-CoV-2 Replication Complex hubs.ly/H0Bf8CR0

Using a Morpheus screen: hubs.ly/H0BdWbx0 Rut etl al Investigated the substrate specificity of SARS-CoV-2. Read more about their work here in their preprint: hubs.ly/H0BdNJB0 #COVID