MD FASN | Professor & Nephrologist | #SingleCell & spatial multiomics | Kidney repair & prevention | #ERCStG | Editorial board @JASN_News
Kiel, Germany
Joined January 2021
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For anyone coming from X:
Official BALZER LAB account is now at🦋
👉 bsky.app/profile/balzer-lab.…
Alright, #MedTwitter #NephTwitter 🫘 The time has come to move on... Would love to stay in touch! Find me at 🦋 bsky.app/profile/ms-balzer.b…
Alright, #MedTwitter #NephTwitter 🫘 The time has come to move on... Would love to stay in touch! Find me at 🦋 bsky.app/profile/ms-balzer.b…
Michael S. Balzer retweeted
Original Article: Long-Term Effects of Empagliflozin in Patients with Chronic Kidney Disease (EMPA-KIDNEY) nej.md/3NE3W7K
#KidneyWk | @ASNKidney
ALT Panel A: A Kaplan–Meier plot of progression of kidney disease or death from cardiovascular causes (composite primary outcome) in the empagliflozin group and the placebo group during the combined active- and post-trial periods. Panel B: Hazard ratios for a primary-outcome event among patients in the two groups during the active- and post-trial periods.
Instrumental work by Hiroaki Kikuchi from @MarkKnepper6 lab on what instigates renal compensatory growth #kidneyweek2024
Fantastic talk by @MiguelCheSoares on labile heme and Host-Microbe interactions in the context of AKI #KidneyWk2024
Want to know how to extend your kidneys’ lifespan? Starting off “Opposing Demands in Kidney Injury: How to Adapt” with Martin Späth leveraging caloric restriction for kidney injury. #kidneyweek2024
Is fibrosis🐓or🥚? Fantastic talk in the spatial session by @Ina_M_Schiessl on intravital tracking of kidney tubules. #kidneyweek2024 #kidneyweek
Congrats @AminAbedini1990 @KSusztak and team! 🔥🔥🔥
🔥😀Super-super excited to report the publication of "Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression" in @NatureGenet rdcu.be/dONoW by @AminAbedini1990 and Jon Levinsohn #kidney #diabetes #spatial transcriptomics
Michael S. Balzer retweeted
Prof. Dr. Tobias Huber aus dem #UKEHamburg ist vom @ERC_Research mit ERC Advanced Grant ausgezeichnet worden. Sein Forschungsprojekt zu einer Form der Nierenfilterschädigung (fokal segmentalen Glomerulosklerose, FSGS) wird mit 2,5 Mio. Euro gefördert: t1p.de/m49gz
Michael S. Balzer retweeted
"The nephrology community has lost one of its truly remarkable figures..." Drs @JochenReiser and Martin Zeier remember the life and legacy of Eberhard Ritz bit.ly/JASN0304
ALT Eberhard Ritz 1938-2023
Michael S. Balzer retweeted
With tremendous joy, I share that our patient who received a gene-edited pig kidney transplant was discharged home today after removal of his dialysis access. We hope that this is a first step that will bring hope to many patients waiting for a kidney transplant #xenotransplant
Michael S. Balzer retweeted
Thrilled to share that Dynamo v1.4 (github.com/aristoteleo/dynam…) for single cell and metabolic labeling enabled RNA velocity vector field learning and prediction is now on PyPi! This is one of our biggest upgrades of Dynamo since early 2023. In this new release, we made the following extensive changes: 1) Implemented an interactive Shiny web application for in silico perturbation and least square action path analyses, see: dynamo-release.readthedocs.i… 2). More 3D plots with Plotly and Pyvista:
3D scatters with Plotly and Pyvista: - dyn.pl.scatters_interactive().
3D vectors with Plotly and Pyvista: -dyn.pl.cell_wise_vectors_3d().
3D topography with Plotly and Pyvista: - dyn.pl.topography_3d().
3D animation with Pyvista: dyn.mv.PyvistaAnim().
3). Extensive reorganization of the code in tools module: dynamo-release.readthedocs.i… 4). Various tutorial updates and bug fixes are made. See our detailed release log here: dynamo-release.readthedocs.i… In our next release, we are aiming to integrate Storm (biorxiv.org/content/10.1101/…) and a few other new methods in our next releases. Stay tuned!
Michael S. Balzer retweeted
🎉 Happy to share our first 📜 2024!🔬 Our review article in @GenomeMedicine on the innovative use of spatial multi-omics. Discover how these technologies are unlocking new understandings of cardiovascular disease. 🚀rdcu.be/dwnVi @UniklinikAachen @SpringerNature @RWTH
❓❓❓Ever wondered how well pre-clinical #kidneydisease models translate to the human?
Recent #singlecell work led by top students in my lab, Kathrien Abdank & @cetin_sz, provides answers.
1/🧵
CONCLUSION: our straightforward analytical framework
✅effectively positioned pre-clinical models along human biology (AKI-to-CKD);
✅showcased robust biological pathway concordance across species;
✅identified problematic datasets and samples.
6/🧵
Huge thank you 🙏to all involved: 👏@cetin_sz, Kathrien Abdank, @AminAbedini1990 @KSusztak Kai-Uwe Eckardt
@BIH_Innovation @EKFStiftung
Check out the 🔥paper in @NDTsocial: doi.org/10.1093/ndt/gfae030
Eo/🧵