@pcstirling

Senior Scientist at BC Cancer and Associate Professor in Medical Genetics at UBC (he/him).

 Vancouver
Joined July 2013
  • Tweets2.1K
  • Following685
  • Followers799
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Peter Stirling retweeted
Arun Kumar@arunk_9515 Apr 2024
New @StirlingLab paper alert! Hot off the press at @NatureComms, we focus on the role of SUMOylation in the formation and clearance of Intranuclear Quality Control (INQ) sites under DNA damage. (1/10) nature.com/articles/s41467-0… #proteostasis #genomeintegrity

Dynamics of DNA damage-induced nuclear inclusions are regulated by SUMOylation of Btn2

Nature Communications - Maintaining a healthy nuclear proteome during DNA damage is important but its regulation is poorly understood. The authors here show that a SUMO modification of the small...

nature.com
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Peter Stirling retweeted
Russ Cook
@hardestgeezer7 Apr 2024
The first person ever to run the entire length of Africa. Mission complete🫡 – at Tunisia
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Peter Stirling retweeted
Russ Cook
@hardestgeezer23 Jan 2024
Day 278 of running the entire length of Africa. Need your support now more than ever on this one. Appreciate you all🫡 – at Senegal
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Peter Stirling retweeted
Kurrasch Lab@KurraschLab31 Oct 2023
The University of Calgary is hiring for Assistant Professor positions in Neuroscience. Please check out more details on the UCalgary Careers page and apply! @UCalgary @UofCr4kids @HotchkissBrain @owerkocentre @UCalgaryMed #neuroscience #neurofaculty
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Peter Stirling retweeted
Anna Blakney@AnnaBlakney18 Aug 2023
We are ✨hiring✨ not one, not two, but three new faculty positions in @SBME_UBC! The focuses are on cell therapies for autoimmune diseases, neuroengineering and immunoengineering. Passion for pranking @PZandstra on April Fool's desired, but not required. Please RT (RX? Idk)!
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I am very pleased to share my new preprint! We use a new assay to interrogate how human TOP2a resolves catenated DNA. Here is a thread: 1/n biorxiv.org/content/10.1101/…

Substrate accessibility regulation of human TopIIa decatenation by cohesin

Human topoisomerase II alpha (TOP2α) is the main mitotic decatenase [1][1]–[3][2] resolving intertwines between sister chromatids that form during DNA replication [4][3]. Here, we employ quadruple-...

biorxiv.org
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Two of my favs - congrats!!
Donnelly Centre@DonnellyCentre10 Nov 2023
Congratulations to Artem Babaian and Elena Kuzmin for winning the @GairdnerAwards Early Career Investigators competition! 👏 Both members of the @DonnellyCentre community presented their research breakthroughs at #GairdnerScienceWeek. Learn more 👉 uoft.me/Gairdner2023
Composite of photos of Artem Babaian and Elena Kuzmin speaking at Gairdner Science Week 2023

ALT Composite of photos of Artem Babaian and Elena Kuzmin speaking at Gairdner Science Week 2023

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Peter Stirling retweeted
Janel Kopp@JanelKopp9 Nov 2023
The final paper of three from our graduate student, Dr. Anni Zhang (@annizubc) is now out in @Cell_Metabolism. Check out her excellent work showing that Insulin receptors in pancreatic acinar cells are important for KrasG12D-driven cancer initiation. cell.com/cell-metabolism/ful…

Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing...

Obesity increases the risk of pancreatic cancer as a consequence of hyperinsulinemia. Here, Zhang et al. reveal that loss of insulin receptors in acinar cells curbs hyperinsulinemia-linked pancreatic...

cell.com
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I’m asking children 10 years or under to send us their best penguin drawings for a chance to be featured in the new album artwork (in the white space) and also the video! Click here to apply - pennypenguinart.com #Raffi #PennyPenguin @goodlovelies #belugagrads
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Only 2 more days for #TAGC24 abstract submission! community.alliancegenome.org… open until November 9, 2023, 8 pm EST
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#TAGC24 is back in 2024! Bringing genetics together, and allowing you to connect with scientists from all around the world, this conference is not to be missed. @GeneticsGSA Register here: oxford.ly/49eSd9d
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There is still time to submit your YEASTy abstract to #TAGC24 @GeneticsGSA genetics-gsa.org/tagc-2024/

Homepage - TAGC24

BRINGING GENETICS TOGETHER

genetics-gsa.org
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Detection of alternative DNA structures and its implications for human disease dlvr.it/SxnlS4
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Freedom to err: The expanding cellular functions of translesion DNA polymerases dlvr.it/SxgpWt
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Peter Stirling retweeted
Mikko Taipale@mike_tilapia7 Sep 2023
Our latest preprint is out! In a fun collaboration with @DrAnneCarpenter, we conducted a systematic high-content screen to understand the role of protein mislocalization in diverse human disorders. 1/8 biorxiv.org/content/10.1101/…

Pervasive mislocalization of pathogenic coding variants underlying human disorders

Widespread sequencing has yielded thousands of missense variants predicted or confirmed as disease-causing. This creates a new bottleneck: determining the functional impact of each variant – largely...

biorxiv.org
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TT Asst Prof in Appl Environ Microbiol @UBC. If you research microbial physiology, metabolism or ecology, including the discovery, cultivation, isolation or engineering of microorganisms apply to join an amazing group of colleagues. academicjobsonline.org/ajo/j…. PLEASE share widely.
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Peter Stirling retweeted
Andrew Craig@AndrewWCraig5 Oct 2023
We Ask the Canadian Government to Increase CIHR’s Budget - Sign the Petition! chng.it/D5WX8gPc via @CdnChange
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Did you know: registration is now open for the TAGC24 & IMGS members get a $50 discount off the GSA Non-Member rate; check your email for the code! (If you are a GSA member you get a GSA discount, not both) Early Registration deadline is December 13.
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Peter Stirling retweeted
Prachee Avasthi
@PracheeAC6 Oct 2023
ICYMI, we’re still looking for another editor to join @thecrispress on our publishing team @ArcadiaScience. If you’re excited to push the boundaries of how we share science, apply now! jobs.lever.co/arcadiascience…
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DNA2 nuclease inhibition confers synthetic lethality in cancers with mutant p53 and synergizes with PARP inhibitors dlvr.it/SwhTVl

DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with...

This study identifies a new DNA2 inhibitor as a synthetic lethal targeted therapy for mutp53-harboring cancers, and provides a new therapeutic strategy by combining DNA2 inhibitors with PARP inhibi...

pubmed.ncbi.nlm.nih.gov
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