Vasculitis doctor and researcher, father of three girls, diehard Celtics fan, musician
Joined January 2019
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Peter Grayson retweeted
News: Skin manifestations in VEXAS syndrome are common and provide an important early clue to the diagnosis of this life-threatening disease.
Read the full NIAMS-led study via @JAMADerm 🔒. Abstract: jamanetwork.com/journals/jam…
ALT A graphic from the paper with illustrated depictions of ear or nose chondritis, urticarialike lesions, medium-vessel vasculitis, periorbital edema, neutrophilic dermatosis, and leukocytoclastic vasculitis on a person.
Peter Grayson retweeted
A look back at the first workshop on #VEXAS syndrome! > 100 participants from 19 countries came in Paris. Thanks to the support of @contactfai2r. @TerrierBen @mekinian2 @petercgrayson @maferradastrong @KosmiderO @_ERNRITA @RimBourguiba1 @CiprianJurcut
Many thanks to our French colleagues for hosting the first international VEXAS Congress in Paris. The only thing that was better than the science was the friendship. We had the best time with you! @SophieGeorgin @TerrierBen @mekinian2 @bhavishap29 @emmamgroarke @maferradastrong
Peter Grayson retweeted
UBA1 somatic mutations of indeterminate potential? our provocative finding in @AllofUsResearch led by @rheumrob with @jamesfbrogan, @kwbyram & @petercgrayson
@VUMC_MedPSTP, @VUMCRheum @NIH_NIAMS
Somatic mutations in UBA1 cause VEXAS, a severe inflammatory syndrome. For the first time, researchers have found 74 people with the mutation who don't have VEXAS. Studying them may give a peek into the earliest phases of disease.
In A&R
loom.ly/fZWodK4
@rheumrob
ALT Analysis of 245,368 diverse individuals in NIH All of Us Program finds incomplete penetrance of VEXAS-defining UBA1 p.Met41Leu somatic variant. Graphical abstract created with BioRender.com
Population databases have shown very different findings related to VEXAS, reflecting selection bias. In AllofUs, 74 people with VEXAS mutations, 62 of them were female, 100% were p.Met41Leu, unclear if they have any disease phenotype. Terrific work led by @rheumrob !!!
Somatic mutations in UBA1 cause VEXAS, a severe inflammatory syndrome. For the first time, researchers have found 74 people with the mutation who don't have VEXAS. Studying them may give a peek into the earliest phases of disease.
In A&R
loom.ly/fZWodK4
@rheumrob
ALT Analysis of 245,368 diverse individuals in NIH All of Us Program finds incomplete penetrance of VEXAS-defining UBA1 p.Met41Leu somatic variant. Graphical abstract created with BioRender.com
Clonal haematopoiesis across the age spectrum of vasculitis patients with Takayasu’s arteritis, ANCA-associated vasculitis and giant cell arteritis ard.bmj.com/content/early/20…
New collaborative work from rheum and heme at NIH @fergutierrezro1 @bhavishap29 @KQuinnRheum @NealSYoung1
We looked at CH prevalence in three forms of vasculitis that span the age spectrum.
Found that:
1. Age stronger driver of CH than vasculitis
2. Mostly small clones in DNMT3A and TET2
3. Association of clone size and relapse in GCA (unclear direction of association)
#ACR23 need to find better way to incentivize attendance on the last half day of ACR Convergence. Turnout again pretty abysmal. Not fair to presenters of some very nice work today. End on full day or do something big at the very end.
Peter Grayson retweeted
Everyone at #ACR23 be sure and tune in to @AtefehGho’s talk this Wed showcasing our @nih_nhlbi @MayoClinic @NIH_NIAMS collaboration reporting on the high rates of thrombosis (mainly #VTE) seen in our #VEXAS cohort. acr23.eventscribe.net/search…
First ever non-HLA germline genetic association identified in RP. Masters thesis work from Yiming Luo from our group at NIH. @RP_Organization @maferradastrong
Ultra-rare genetic variation in relapsing polychondritis: a whole-exome sequencing study ard.bmj.com/content/early/20…
Peter Grayson retweeted
#ACR23 check out @rheumrob's late breaking poster tomorrow - he has identified individuals with somatic UBA1 mutations who are resilient to VEXAS cdmcd.co/vabX8j
Full details in his preprint: medrxiv.org/content/10.1101/… @ACRheum @VUMCRheum @VUMC_MedPSTP
Peter Grayson retweeted
@maferradastrong is an inspiration.
She was driven to improve outcomes for relapsing polychondritis, the disease she lives with, & now she leads her field.
Truly the model of a patient-physician, always so much to learn from her.
#ACR23 Review Course @RheumNow @Polychondritis
Family talking this morning about the “speaker of the house” being removed. Five year old looked concerned and nervously asked, “Alexa?” 🤣🤣🤣
Peter Grayson retweeted
👆🏼#VEXAS syndrome is believed to only affect individuals above the age of 50.
😮We describe an early-onset case in a 23 y/o 🙎🏽♂️ with relapsing polychondritis.
🗝️Test for UBA1 mutations🧬, regardless of age, in adults with a VEXAS clinical phenotype.
@ivette_pataki @RheumJnl
@EcemSevimMD from NIAMS Rheumatology Fellowship Training Program speaking about micro vascular disease at Society Vascular Medicine Conference @YogenKanthi
Best part of the VEXAS project from the science perspective is the collaborations! Rheum + Heme is an amazing confluence of interests.
Excited to share our work on CH in #VEXAS syndrome in collaboration with amazing colleagues at @MayoClinic
Full article - authors.elsevier.com/a/1hPeT…
@nih_nhlbi
@fergutierrezro1 @MrinalPatnaik @petercgrayson @NealSYoung1
