
Associate Professor, Renal Pathologist and #kidneyomics Researcher. Tweets are my opinions not medical advice. #renalpath
Seattle, WA
Joined August 2012
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Shreeram Akilesh π retweeted
The inherent complexity of the kidney makes it an ideal validation platform for showcasing topographical molecular mapping: Multiscale topology classifies cells in subcellular spatial transcriptomics | Nature nature.com/articles/s41586-0β¦
Shreeram Akilesh π retweeted
β‘οΈπ¬π£ Excited to share our new @Nature article building and evaluating PathChat, a multimodal generative AI copilot and chatbot for human pathology. Article: nature.com/articles/s41586-0β¦ Open Access Link:
rdcu.be/dKC0r
We leverage our previous success in building foundation models for computational pathology such as UNI / CONCH and combine it with the advancements of large vision language models and generative AI to enable PathChat to answer diverse pathology-related queries. We assessed PathChat using both multiple choice diagnostic questions and open-ended questions.
Congratulations to @MYLu97 @chenbowen118 @DFKW_MD @richardjchen and everyone else who contributed to this work.
Also see blog post from @MYLu97 about this work: linkedin.com/pulse/towards-m⦠, also teasing the development and preview of PathChat 2, a successor to PathChat 1 bringing new capabilities and substantially improved performance to the state-of-the-art.
Shreeram Akilesh π retweeted
Multi-omic analysis of human kidney tissue identified medulla-specific gene expression patterns
doi.org/10.1016/j.kint.2023.β¦
#kidneydisease #epigenetics @SFB1453_NephGen
#VisualAbstract @podocytes @VCU @uwlabmedpath
Shreeram Akilesh π retweeted
I am very grateful to WA CARES for the Breakthrough Seed Funding grant and @rajmehrotra1122, @deboerih, @uwlabmedpath and @uwurology for matching funds! This broad team-based support enables @podocytes and me to advance our groundbreaking research of kidney cancer.
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Shreeram Akilesh π retweeted
Out today!! This impressive & highly cooperative @NatureGenet publication by @SFB1453_NephGen PIs #AnnaKoettgen, Pascal Schlosser, @MatthiasWuttke, Michael Koettgen, Miriam Schmidts, @SchultUlla, Peggy Sekula, and many more ππ₯³nature.com/articles/s41588-0β¦
Shreeram Akilesh π retweeted
3/3 Technical Winners
Shreeram Akilesh @podocytes
Cytoskeleton
Rac, Rho in opposition
Intact or effaced
Linda Rehaume, Aurinia Pharmaceuticals, BC, Canada
Filtering all day,
Interdigitating bae,
Blood protein to stay!
Shreeram Akilesh π retweeted
We are thrilled to share that our @UWNephrology faculty have won the 2023 ASN Awards! Dr. Ann O'Hare, Distinguished Mentor Award, Dr. Beno Freedman, the Donald W. Seldon Award, Dr. Ian de Boer, Distinguished Researcher Award, and Dr. Kathy Tuttle, the John P. Peters Award! πππ
Shreeram Akilesh π retweeted
The 14th International Podocyte Meeting, #podo23 The future is bright ! From Marylyn Farquhar first seeing the podocytes, the identification of podocyte gene mutations in nephrotic syndrome onto podocyte targeted therapies !
Shreeram Akilesh π retweeted
We're thrilled to share our recent @NatureMedicine study, cracking the decades-old mystery surrounding the identity of cells responsible for producing erythropoietin (Epo) - the key regulator of erythropoiesis and oxygen homeostasis in our bodies. nature.com/articles/s41591-0β¦ (1/16)
Shreeram Akilesh π retweeted
The Yoshino cherry trees in the Quad are nearly 90 years old! #TBT
They were originally planted at the Washington Park Arboretum but were moved onto the campus in 1962 to protect the trees from the construction of SR520. πΈ
#UWcherryblossoms @uwcherryblossom
Shreeram Akilesh π retweeted
So great to see Charlie Alpers receive the ISN Roscoe Robinson award with a gracious acceptance speech and so deserving of this award. A true nephro-pathology leader and scholar
Shreeram Akilesh π retweeted
New Technologies to study Kidney Disease: Spatial Transcriptomics by Dr. Shreeram Akilesh @podocytes
Total live participants: 139
From 32 countries
Watch the session here ππ» my.glomcon.org
#GlomCon #GlomConSeminars
Shreeram Akilesh π retweeted
This Sunday at #GlomCon
A Joint Venture Between GlomCon & Renal Pathology Society
New Technologies to study Kidney Disease: Spatial Transcriptomics
by Dr. Shreeram Akilesh (@podocytes)
via ZOOM
ID: 875 5077 1266
Passcode 202122
sign up ππ» bit.ly/3CGk9EH
Shreeram Akilesh π retweeted
Our welcome party for our incoming residents/fellows! We cannot wait to have you all here!
1st picture π#UWPath
2nd picture Kate, Greg and Ollie with our awesome PDs and Chair of Lab Med and Pathology!
#Path2path #Match2023 #PathTwitter
#PathMatch #Pathology
Shreeram Akilesh π retweeted
Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock @jclinicalinvest jci.org/articles/view/167133β¦
Shreeram Akilesh π retweeted
Congrats to several BBI faculty & researchers, led by Gavin Ha, on Nature Communications paper on Griffin, a framework for accurate tumor subtyping 'generalizable to other cancer types for precision oncology applications'
go.nature.com/3UGYkuH
Shreeram Akilesh π retweeted
Together with @julia_m_murphy @akonvalinka1 and @sarah_crome, I'm so excited and proud to share our article, hot off the press in @NatureComms where we use scRNAseq to profile the transcriptional landscape of healthy human kidney π1/
nature.com/articles/s41467-0β¦
Shreeram Akilesh π retweeted
This week in @Nature we present our #SingleCell dissection of #ApoE4, the strongest genetic variant for #Alzheimers.
ApoE4 impairs #cholesterol #transport, leading to #oligodendrocyte ER accumulation, decreased #myelination.
Restoring transport restores mouse cognition.
#Hope #AD



































