@prade90
pradellab.org
Joined September 2011
  • Tweets11
  • Following59
  • Followers28
Davide Pradella retweeted
Marcus Goncalves
@MarcusDGonApr 21
Check out the #AACR26 morning poster and afternoon lecture from #mdglab all stars: Alex and Maira
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Davide Pradella retweeted
Marcus Goncalves
@MarcusDGonApr 7
Going to #AACR26? Make sure to attend this talk: Targeting metabolism in BRCA-deficient tumors | Cancer Research ⁦@AACR⁩ aacrjournals.org/cancerres/a…

Abstract 6808: Targeting metabolism in BRCA-deficient tumors

Abstract. Up to 10% of all cancers are attributed to genetic predisposition, with inherited mutations in BRCA1 and BRCA2 being the most significant risk factors for developing breast and ovarian...

aacrjournals.org
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Davide Pradella retweeted
Andrea Ventura@aventura7118 Dec 2024
1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! 🧵👇 nature.com/articles/s41586-0…

Engineered extrachromosomal oncogene amplifications promote tumorigenesis

Nature - Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role...

nature.com
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Davide Pradella retweeted
Maira Di Tano@19_maira_9026 Jan 2024
Cycles of fasting mimicking diet enhance the efficacy of Bortezomib and Rituximab in the treatment of CLL. Congrats Franca Raucci and Claudio Vernieri! Proud to be part of this amazing research! @ProfValterLongo @IFOMresearch #CancerResearch aacrjournals.org/cancerres/a…
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Davide Pradella retweeted
Andrea Ventura@aventura7127 Jun 2023
Our latest work on engineering extrachromosomal circular DNAs (ecDNAs) is now available in @biorxiv. In this preprint we describe a novel strategy to engineer the formation of large (>1 Mb), multigenic, amplifications mediated by ecDNAs in cells and mice. biorxiv.org/content/10.1101/…

Immortalization and transformation of primary cells mediated by engineered ecDNAs

Focal gene amplifications are among the most common cancer-associated mutations, but their evolution and contribution to tumorigenesis have proven challenging to recapitulate in primary cells and...

biorxiv.org
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Grazie alla raccolta fondi a nome di @Fraintesa, è stata istituita una Borsa di studio #AIRC per l'estero, che permetterà a Maira Di Tano di fare ricerca sul tumore al pancreas. #grazieFraintesa Continua a donare, scopri la storia di Francesca 👉 bit.ly/3lWbFjM
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Davide Pradella retweeted
Andrea Ventura@aventura7128 Sep 2021
Paper out: a collaborative effort led by Dr. Gaspare La Rocca and Brian King to investigate the functions of miRNA in adult tissues using a novel genetically engineered mouse model. doi.org/10.7554/eLife.70948

Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

A new genetically engineered mouse strain is described in which miRNA activity can be acutely and reversibly inhibited, showing that in a subset of adult tissues miRNA activity is dispensable under...

elifesciences.org
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Scoperto un nuovo meccanismo per "affamare" i tumori In uno studio, pubblicato su @NatureComms e diretto dal #Cnr_Igm, è stata individuata una nuova variante proteica espressa unicamente sulla superficie dei vasi sanguigni tumorali Leggi di più👇 cnr.it/it/comunicato-stampa/…
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An UNC5B splicing isoform is required for blood vessel development @CNRsocial_ go.nature.com/2VJ2SrS
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Part of my Ph.D. work at the IGM-CNR: characterization of a ligand-insensitive UNC5B alternative splicing variant in vascular and tumoral angiogenesis. @NatureComms @CNRsocial_ @unipv nature.com/articles/s41467-0…
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