@pylelab

RNA Biology, RNA tertiary structures, viral RNA, and RNA-protein machines. Based at @MCDB_Yale. All opinions and RTs are our own.

 New Haven, CT
pylelab.org/
Joined April 2021
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  • Following143
  • Followers914
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📢ONLINE event this month! ⏲️5pm GMT, 14th Dec 2023, next Thursday! This month we happily invite Danny and Ling to show their exciting RNA structural stories! Please register our mail list for zoom link🥳 Many thanks to our sponsors @RNASociety @lexogen
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pylelab retweeted
HHMI
@hhmi_science1 Dec 2023
“Incredibly dynamic” #RNA: Anna Marie Pyle’s group @pylelab sheds light on how a section of bacterial RNA catalyzes a reaction that frees it from its parent strand. This ancient splicing method still closely resembles that employed in human cells. 🔗 hhmi.news/3uCAuJb
for the 20231201 pyle rna splicing news release include image credit: Margot Riggi and Janet Iwasa

ALT for the 20231201 pyle rna splicing news release include image credit: Margot Riggi and Janet Iwasa

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hhmi.org/news/how-rna-splici…

How an RNA Splicing Machine Splices Itself | HHMI

Humans and many other organisms depend on molecular systems that cut and reconnect their genetic material. A new study explores the workings of an ancient splicing mechanism still present in bacter...

hhmi.org
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Happy to share our new Nature paper looking at intron RNP structures through the stages of splicing!
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more replies
Also check out this movie that animates the full life cycle of the group II intron RNP (thanks to Margot and Janet again!).
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Congratulations again to @Ling97520113, @ArthurLiuShuo and Kevin!
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pylelab retweeted
nature
@Nature23 Nov 2023
Nature research paper: Structural insights into intron catalysis and dynamics during splicing go.nature.com/3QTKPYL
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A recent paper from the Pyle Lab discusses the use of MRT-ModSeq for the detection of RNA modifications using 2D mutational profiles. Read more here: sciencedirect.com/science/ar…
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Can #RNA recognize small compounds specifically? Can the #splicing core be targeted by #smallmolecules? Exciting answers in our new preprint on the molecular mechanism of splicing inhibition by intronistat b biorxiv.org/content/10.1101/… @EMBLGrenoble @IITalk @devivo_marco

Targeting the conserved active site of splicing machines with specific and selective small molecule...

The self-splicing group II introns are bacterial and organellar ancestors of the nuclear spliceosome and retro-transposable elements of pharmacological and biotechnological importance. Integrating...

biorxiv.org
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Principles of #lncRNA structure-functional connections emerging! Our new work in press shows how lncRNAs use non-canonical #GUwobble motifs to shape their molecular structure and define their function doi.org/10.1016/j.biochi.202… @EMBLGrenoble @KariSabalette @epifiz87 @elsbiochimie
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Congratulations to all the GRC 2023 Nucleic Acids poster award winners! The poster sessions were one of the highlights of the conference! If you’re thinking about applying for the 2025 GRC, we definitely encourage presenting a poster about your ongoing science! #grcnucleicacids
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The GRS Nucleic Acids was also a great success! Thank you Mano and @KrishnanYamuna for spending time with the trainees and ECRs!
Anantha Narayanan@ananthb3lyp21 Jun 2023
2023 GRS Nucleic Acids @GordonConf! It was my honor and privilege to chair this meeting! Two days of cutting edge science followed by an amazing panel conversation with Dr. Mano @Alnylam and @KrishnanYamuna! I shall remember this meeting forever! #grs2023 #grs #nucleicacids
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Dear Nucleic Acid GRC friends! Thank you all for attending the meeting, for all your energy, insights, and enthusiasm about our wonderful area of science.  We look forward to seeing you in 2025. #grcnucleicacids #grc23
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Special thanks to Xi Yang, NIH, for the group photo on the mountain! Please feel free to tag everyone in the photo in the comments section!
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