@raikunal

Associate Professor at MDACC; Student of Life; Passion = Chromatin and Cancer; Aspire to make a positive difference.

 Houston, TX
railab.org
Joined July 2010
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  • Followers499
3Media
Join us at #FoGBoston for insights from @raikunal (Associate Professor & Scientific Director, @MDAndersonNews Epigenomics Therapy Initiative) on his work surrounding the role of #epigenetic changes in cancer progression. More info here: hubs.la/Q022tvn70 #cancergenomics
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Honored and thrilled to receive Young Alumni Achiever Award 2023 from my alma mater, Indian Institute of Technology, Kharagpur @IITKgp
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Our new study shows NRF2-driven enhancer reprogramming contributes to chemotherapy resistance in head and neck cancers, providing rationale for targeting NRF2 to overcome cisplatin resistance. Led by @earslan_tamu and Dr. Abdullah Osman. @MDAndersonNews aacrjournals.org/clincancerr…
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Recently got my trophy for Potu N Rao Award for Excellence in Basic Science 2022. Many thanks to Division of Cancer medicine @MDAndersonNews for the recognition. I owe to this to the tireless efforts of the present and past trainees in my lab.
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Kunal Rai retweeted
Elias Orouji@orouji8 Oct 2022
Happy to share our Review on chromatin state dynamics and computational tools to explore differential CS in normal vs. cancer cell | @ Briefings in Bioinformatics | w/ @aayushraman | academic.oup.com/bib/advance… | @PMResearch_UHN @broadinstitute @MDAndersonNews #epigenomics #chromatin
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Our preprint on epigenome reprogramming in R and NR melanoma patients treated with ICB suggests an enhancer biomarker and BETi+aPD1 combo. Great collaboration with @manoliskellis @gmboland @MMattohti @tangming2005 @JenWargoMD @dliu_ccb @MDAndersonNews biorxiv.org/content/10.1101/…

Enhancer Reprogramming in Melanoma Immune Checkpoint Therapy Resistance

Immune checkpoint blockade (ICB) therapy has improved long-term survival for patients with advanced melanoma. However, there is critical need to identify potential biomarkers of response and action...

biorxiv.org
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Preprint @raikunal @MDAndersonNews with @gmboland @MGHCancerCenter @manoliskellis @MIT: Enhancer Reprogramming in Melanoma Immune Checkpoint Therapy Resistance biorxiv.org/content/10.1101/… Nice data from high throughput profiling of clinical samples to functional perturbation study.
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Comparable tumor immune microenvironment in human glioblastoma & murine model: buff.ly/3OdgOk3 @Zamler_Brain @Jianhu_Neural @draettag @HeimbergerAmy @LurieCancer @BrainTumorInst @MDAndersonNews @swatowic @raikunal @tcellsrus @lmks91 @cinziakas @KristinHuntoon @KatTomcat1
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Our collaborative work with Joe Ludwig on DSRCT,showing AR as a therapeutic target that functions through epigenome reprogramming, appeared today in @NatureComms . @MMattohti @MDAndersonNews nature.com/articles/s41467-0…
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Thankful to CPRIT for their support of our research. @MDAndersonNews
CPRIT@CPRITTexas16 Feb 2022
BREAKING NEWS: CPRIT announces 74 new grants for over $112 million to expand innovations in cancer research and prevention in Texas. Check out the release for the entire list of awards. #CPRIT #TexansConquerCancer ow.ly/1AQ050HWOem
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Kunal Rai retweeted
CPRIT@CPRITTexas16 Feb 2022
BREAKING NEWS: CPRIT announces 74 new grants for over $112 million to expand innovations in cancer research and prevention in Texas. Check out the release for the entire list of awards. #CPRIT #TexansConquerCancer ow.ly/1AQ050HWOem
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New research identifies mechanisms behind how fasting can reduce the negative effects of high-dose chemotherapy and radiation therapy: fal.cn/3kqFD @raikunal @TaniguchiMD #EndCancer
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Chris Terranova, Kristina Stemler, Kunal Rai, Helen Piwnica Worms and collaborators - Reprogramming of H3K9bhb at regulatory elements is a key feature of fasting in the small intestine cell.com/cell-reports/fullte…
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Collaborative work with @HusseinAbbas01 @Daver_Leukemia @IamLinghua online now. @KatTomcat1 @praveenbarrodia from my lab contributed significantly to this work. Congrats to all! nature.com/articles/s41467-0…

Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1...

Nature Communications - The response rate of relapsed/refractory acute myeloid leukemia patients to PD-1 checkpoint blockade is low and unpredictable. Authors here show by single cell RNA...

nature.com
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We are looking for two motivated and talented 'Senior Research Scientists" with expertise in protein biochemistry and CRISPR/Cas screening at MDACC Epigenomics Initiative (METI). Biochemist position: bit.ly/3lAPFMc Biology Position: bit.ly/2YK7Nda
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Our study on chromatin states in metastatic melanoma came out today. We demonstrate genotype-specific chromatin state patterns and suggest use of PRC2 inhibitors in NRAS-mutant melanoma. cell.com/cell-reports/fullte… @tangming2005 Chris Terranova Mahinur Maitituoheti @MDAndersonNews
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Also, sharing a review we wrote about application of machine learning tools in epigenomics with a focus on cancer research. @earslan_tamu Jonathan Schulz sciencedirect.com/science/ar…
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Our new collaborative paper with Dr. Keila Torres, sheds light into the biology of and suggests therapeutic approaches for PRC2-deleted MPNST - a soft-tissue sarcoma. link.springer.com/article/10… Led by Veena Kochat & @aayushraman . @MDAndersonNews .
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It’s time to change this slide! @FDA approval today of #sotorasib. Congrats @JonathanOstrem & Ulf Peters on launching the successful attack with tethering from @realJimWells and scientists at Wellspring! Many steps-great to see the summit reached!! @UCSFCancer @HHMINEWS
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