@reg_so

organic chemistry, photo-triggered processes, DNA-templated synthesis, looking for TT for 2027!!

 New York, NY
regcsoblog.wordpress.com
Joined April 2012
  • Tweets2.3K
  • Following2.7K
  • Followers722
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Dr. Reg So retweeted
AggarwalLab@AggarwalLab19h
Two distant stereocentres. One smooth catalytic cycle! Our latest @JACS installs 1,6-stereocentres via Ir-cat asymmetric allylation of resorcinol boronate complex, enabling the total synthesis of merocyclophane A. Congrats, team! 🔗 doi.org/10.1021/jacs.6c14045 @BristolChem

Simultaneous Installation of 1,6-Stereocenters by Asymmetric Allylation of Resorcinol Boronates:...

Abstract. Installing multiple noncontiguous stereocenters in a single catalytic event offers a powerful platform for constructing complex three-dimensional

pubs.acs.org
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We merged cobalt catalysis with the photochemistry of arylazo sulfones bearing dyedauxiliary groups for carbonylation processes @AdvSynthCatal Congrats to @komaljaiswal_96 for this collaboration! doi.org/10.1002/adsc.70830

Visible‐Light Cobalt‐Catalyzed Synthesis of Aroyl Amides From Arylazo Sulfones

Blue Light and Cobalt Catalysis for Synthesis! A versatile strategy that combines photoactive arylazo sulfones as substrates and Co2(CO)8 as a catalyst for the preparation of aromatic amides is...

advanced.onlinelibrary.wiley.com
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A light-activated morphine derivative relieves pain in mice. You better invest in tanning salons. cen.acs.org/biological-chemi…

A light-activated morphine derivative relieves pain in mice

Local activation could deliver targeted therapy with fewer side effects

cen.acs.org
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Check out this Perspective in #JMedChem: gem-dimethylcarbinol can be considered as a tert-butyl bioisostere. Add C(CH3)2OH to your list of favorite bioisosteres! go.acs.org/ePz
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Dr. Reg So retweeted
Ritter Lab@ritter_labOct 19
In @J_A_C_S, we show the extension of our nitrate-reduction-based diazotization strategy to aliphatic amines! Consecutive nitrate reduction by substoichiometric hydroquinone is key and enables in-situ diazotization followed by (pseudo)halogenation! 🔓 tinyurl.com/36es3e3f
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Dr. Reg So retweeted
Ivan Zanoni
@Lo_ZanziOct 17
#WeekendRead! #EveryCellIsAnImmuneCell! #InterferonsFriendsOrFoes? Nowosad, Lund &co show @ImmunityCP that germinal center size is limited by lymphatic endothelial cells #LECs to maximize T-B cells interactions & antibodies. Type I IFNs disrupt these LECs! cell.com/immunity/fulltext/S…

Lymphatic constraint of germinal centers optimizes protective antibody responses

Lymphatic vessel networks remodel during infection to regulate antigen and immune cell dynamics, yet whether these changes impact humoral immunity remains unknown. Mudianto et al. demonstrate that...

cell.com
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A new review by Kudo (A01) in Natural Product Reports highlights the biosynthetic stages and significance of C-methylation in natural product biosynthesis. doi.org/10.1039/d6np00056h

C-Methylated natural products: biosynthetic stage and significance of C-methylation

Covering: up to 2026 C-Methylation is a fundamental transformation in natural product biosynthesis. Although methyl groups are often regarded as simple fun

pubs.rsc.org
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Proud to present our newest new-to-nature #enzyme activity, primary amination of aromatic feedstocks using simple hydroxylamine. @caltechCCE #directedevolution
Katie Sicinski@kathleen_sicOct 14
New in @ACSCentSci! 🧪 We engineered biocatalysts that selectively install primary amines onto aromatic feedstocks using hydroxylamine as the nitrogen source. Huge thanks to my co-authors: @CaseyAtTheVat, Ethan Lin, @Yueming_Long_ @francesarnold doi.org/10.1021/acscentsci.6…
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Dr. Reg So retweeted
Waser Group@LcsoLabOct 14
The last work of Stefano Nicolai, Daphne Lucidarme and Matthew Wodrich on the formal cycloaddition of azadienes and bicyclobutanes is now accepted in Chemical Science! doi.org/10.1039/D6SC05550H
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Deprotonation and visible-light excitation generate a highly reducing excited state capable of activating strong C–Hal bonds. Congrats to Alex and @IndrajitGhosh85 Acridone Anion as a Highly Reducing Visible-Light Photocatalyst doi.org/10.1039/D6CC05207J
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From stoichiometric donor–acceptor assemblies to catalytic turnover: what makes EDA complex catalysis work? Check out our latest review in Angewandte Chemie, exploring the design principles and mechanistic requirements of EDA complex catalysis.✨✨ doi.org/10.1002/anie.1736780
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Are you looking for a sustainable way to synthesize heterocycles ? ♻️ Check our latest @ACSChemRev on hetero-photocycloaddtions (HPCs) 💡 🫴shorturl.at/tBH0D Congrats to all the authors on this work ! 🎉 #Photochemistry #OrganicChemistry
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Former undergraduate Abby Bracken, who is now a graduate student with Prof. Mark Levin (@group_levin) at the University of Chicago, just published her first paper in Nature! Proud of you @abbybracken! nature.com/articles/s41586-0…

Synthesis of pyrroles from isoxazoles by an O-to-C skeletal edit

Nature - A one-pot skeletal-editing reaction replaces isoxazole oxygen with carbon to form challenging pyrroles, enabled by an N-propargylic enaminone intermediate and a computational model...

nature.com
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Dr. Reg So retweeted
Yulab@YulabJinOct 10
Our sixth Account on CH activation focus on transient covalent approach to boost metal substrate affinity: from the discovery of L,-X TDG to total synthesis. pubs.acs.org/a/5448172?guest…
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A collection on the last 26 years of works on photo heterocycloadditions. 🫴pubs.acs.org/chreay/article/… Hope the community will find it useful! Huge congrats to @CristianRosso92 @sara_cuahuetes @Er_Goti @VascoCorti @e_marcantonio95
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Dr. Reg So retweeted
Barham Lab@BarhamLabOct 8
🚨After 5y in making, unveiling a special discovery🌌in @Chem_CP: Cross-coupling transient(vinyl/sp!) radicals.🚫Ni/Fe/radical sorting/hydrazides.✅Covalent-rotating organoPC💡dyads template 2 precursors, generate& cross-couple radicals in close proximity tinyurl.com/mtkd45p4
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Now online: Modular synthesis of 3,3-diaryloxetanes go.​nature.​com/4dmzRak 🧪
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Dr. Reg So retweeted
Matt Disney
@disney_labOct 7
This is a fascinating Nobel Prize, and congratulations to the winners. I would be remiss, however, not to acknowledge Donna Blackmond’s mechanistic brilliance and her substantial contributions to our understanding of this chemistry.
The Nobel Prize
@NobelPrizeOct 7
Kenso Soai – awarded the 2026 #NobelPrize in Chemistry – designed the first chemical reaction in which only one of the potential mirror images was formed. Other than life itself, no one had ever achieved this feat. The Soai reaction is one of the most spectacular chemical experiments ever conducted.
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Happy to share our new paper in Nature Communications (@NatureComms )!! "Transmembrane PhoxID: photoproximity labelling across the plasma membrane in vivo" nature.com/articles/s41467-0…

Transmembrane PhoxID: photoproximity labelling across the plasma membrane in vivo

Nature Communications - Transmembrane proteins interact with molecules on both sides of the cell membrane to regulate cellular functions. Here, the authors develop tmPhoxID, a proximity labelling...

nature.com
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Dr. Reg So retweeted
AggarwalLab@AggarwalLabOct 5
Think outside the box, but for stubborn thiazoles, think outside the ring! Our latest @angew_chem, (in collab w/ @merckgroup) LiBAP cross-coupling, exploits an out-of-ring sulfinyl activation unlocking 1,2-migration that thiazoles resist. onlinelibrary.wiley.com/doi/… @BristolChem

Aromatic Pummerer‐Promoted Stereospecific Cross‐Coupling of Thiazoles With Boronic Esters

A lithiation–borylation–aromatic Pummerer (LiBAP) strategy enables stereospecific, C5-selective C(sp2)–C(sp3) cross-coupling of thiazoles with boronic esters. By using exocyclic sulfoxide activation...

onlinelibrary.wiley.com
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