Microbiologist and metabolomics specialist, Assistant Professor Mayo Clinic, passionate about microbiome therapeutics & personalized preventive health
Joined May 2009
- Tweets31
- Following378
- Followers96
- Likes129
Ruben Mars retweeted
A month ago, I shared how @GetTinyHealth started in my garage, with my mom hand-packing every kit.
Today, the next chapter: we’ve raised a $33M Series B led by @BCapitalGroup, bringing our total funding to $46M.
From newborns to centenarians, we’re building Tiny Health for you. ❤️
Ruben Mars retweeted
We don't make the results, we just report them!
We're glad @_katetolo's doing so well. 🧬 And yes, we do have a test for that. tinyhealth.com/memberships/t…
This is her vaginal microbiome report. 100/100 score.
Top 1% of all vaginas.
Her sample is dominated by the single most protective bacterial species a vagina can host (Lactobacillus crispatus).
Only about 25-30% of reproductive age women globally are L. crispatus-dominant, and “dominant” usually means above 50%. Kate is at 98.7%.
The lab found nothing bad to report. (no gardnerella, Candida, STIs, opportunistic pathogens, aerobic vaginitis markers, etc.)
This is linked to lower risk of BV, UTIs, yeast infections, HPV persistence, HSV-2 and HIV acquisition, preterm birth, and improved IVF outcomes.
A vaginal microbiome is downstream of everything: sleep, glucose control, stress, gut health, sexual health, immune function, what you eat, and what you put in it.
Ruben Mars retweeted
Top 1% of all vaginas tested!
This is a real Tiny Health vaginal microbiome report.
L. crispatus at 98.7% is linked to lower risk of BV, UTIs, yeast infections, and better fertility outcomes.
This is her vaginal microbiome report. 100/100 score.
Top 1% of all vaginas.
Her sample is dominated by the single most protective bacterial species a vagina can host (Lactobacillus crispatus).
Only about 25-30% of reproductive age women globally are L. crispatus-dominant, and “dominant” usually means above 50%. Kate is at 98.7%.
The lab found nothing bad to report. (no gardnerella, Candida, STIs, opportunistic pathogens, aerobic vaginitis markers, etc.)
This is linked to lower risk of BV, UTIs, yeast infections, HPV persistence, HSV-2 and HIV acquisition, preterm birth, and improved IVF outcomes.
A vaginal microbiome is downstream of everything: sleep, glucose control, stress, gut health, sexual health, immune function, what you eat, and what you put in it.
Ruben Mars retweeted
Microbiome science is poised to redefine cancer care- but only if we move beyond correlations.
The future lies in:
🎯Mechanistic precision
💻AI-guided interventions
🌎Real-world clinical validation to deliver more effective and tolerable cancer therapies.
Check out more below from @KashyapPurna 's recent publication! ⬇️
rdcu.be/eXx4D
#Mircobiome #GI #Excellence
Ruben Mars retweeted
New online! Harnessing the microbiome for cancer therapy nature.com/articles/s41579-0…
Ruben Mars retweeted
Using a reverse translation approach, @KashyapPurna and team identified a previously unrecognized role for the small intestinal microbiome and a specific microbial member in driving abdominal pain, a common and debilitating gastrointestinal symptom.
Learn more about their findings in the publication below! @jclinicalinvest
jci.org/articles/view/190638
#research #innovation
An exciting step for Tiny Health publishing their first randomized controlled trial on C-section infants:
In response to the intervention program not only a dramatic shift in the gut microbiome was seen but even a reduced incidence of atopic conditions in the first year of life.
Full paper: onlinelibrary.wiley.com/doi/…
Ruben Mars retweeted
Today, I’m thrilled to announce our $8.5 million Series A round led by @SperoVentures, alongside partners @OverwaterVC, @nextcoastVP, @PetersonVenture, Modi Ventures, Tamarisc Ventures, @Cartancapital, and Taylor Sittler, Co-founder of @Color. axios.link/49VFat0
Ruben Mars retweeted
Our review now online @AGA_Gastro @rubenmars outlines current approaches & gaps and provides roadmap for accelerating translation of #gutmicrobiome science towards precision therapies in #FGID like #IBS. integrated #multiomics #AI longitudinal studies gastrojournal.org/article/S0… – at Minnesota, USA
Ruben Mars retweeted
Check out our paper in @iScience_CP on role of bacterially derived tryptamine in mucus release from goblet cells and sex-dependent attenuation of inflammatory response to DSS #IBD @MayoClinicCIM @MayoClinicGIHep @mfgrp @GutBugs2 @rubenmars @GFarrugiaMD sciencedirect.com/science/ar… – at Minnesota, USA
Ruben Mars retweeted
What is the best strategy for moving microbiome-based therapies for functional gastrointestinal disorders such IBS into the clinic? @rubenmars, Frith & @KashyapPurna updates major challenges in this field via @AGA_Gastro ow.ly/jEXR30rmhQQ
Ruben Mars retweeted
Ever wonder why longitudinal studies in the microbiome are important? You can find signals otherwise lost in noise! bit.ly/3m5WDqt
Ruben Mars retweeted
Multiple potential therapeutic targets for next-gen #probiotics – SCFA/tryptamine producing native/ engineered bacteria for IBS-C #syntheticbiology microbes that convert primary to secondary bile acid for IBS-D and hypoxanthine producing microbial consortia to treat #IBS symptoms
Ruben Mars retweeted
Excited to finally share these exciting findings bit.ly/2ZrJj62. Also check out the press release mayocl.in/3hiyl8Y and the video abstract youtu.be/CxjRJuMVaOU – at Minnesota, USA
New Article online now at Cell: Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome zpr.io/HNygX
Ruben Mars retweeted
Check out our paper @CellCellPress bit.ly/3m5WDqt @rubenmars @KnightsDan integrating longitudinal host/#microbiome multi-omics in #IBS patients – shows purine starvation from host-microbial co-metabolism may underlie IBS. See video youtu.be/CxjRJuMVaOU @MayoClinic
Ruben Mars retweeted
#Diarrhea-predominant #IBS patients have elevated fecal levels of primary #bile acids chenodeoxycholic & cholic acid, bacterial tryptophan derivative tryptamine and corresponding increase in basal colonic secretion bit.ly/3m5WDqt @mgrover_gi
Ruben Mars retweeted
#Constipation-predominant #IBS patients have lower fecal levels of #SCFA butyrate/acetate and a congruent decrease in secretory response of colon epithelium to #serotonin bit.ly/3m5WDqt
Ruben Mars retweeted
Integrating complementary host and microbial multi-omics data with patient symptoms and host #Physiology allows discovery of #gutbacteria driven functional mechanisms in chronic diseases #guthealth bit.ly/3m5WDqt @tkorem @sambhawa_priya @damato_mauro @NoamBar7