Happy husband, father and grandfa; Bioinfostatistician; Run:walker

Barcelona
Joined January 2011
Alex Sanchez Pla retweeted
🏆 La SEBiBC otorga su I Premio Nacional de Bioinformática y Biología Computacional al Prof. Alfonso Valencia (BSC, ICREA, INB/ELIXIR-ES), por su trayectoria excepcional y su papel clave en el impulso de la disciplina en España. ¡Enhorabuena!  sebibc.es/alfonso-valencia-g…
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Alex Sanchez Pla retweeted
💬 @esantapau de @IMDEANutricion  participará en #SEBiBC2026 en la mesa redonda: “New Working Group on Applied Bioinformatics in Nutrition” Una sesión para explorar nuevas conexiones entre bioinformática, nutrición e innovación aplicada. 🔗 congresosebibc.com
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Honest question for my US friends: Why so little outrage over extrajudicial executions of cartel bosses or drug smugglers? Isn't the 5th Amendment’s right to due process supposed to protect everyone from state-sponsored killings without a trial?
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#rstats I'm very impressed with the new R package tinyplot, and it will be my main graphics package going forward. When I start using a new pkg, I sometimes write up a tutorial, which I've now done for tinyplot, matloff.github.io/Tinyplot-T…
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Cómo la #IA puede intervenir en distintas fases d #RevisiónSistemática 👉Tienen el potencial de acelerar el proceso de producción/actualización de RS 👉Debemos conocer sus ventajas y limitaciones 👉Requiere supervisión y validación humana bibliogetafe.com/2025/04/10/… #medlibs #SysRev
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Alex Sanchez Pla retweeted
Coding is over. Now what? I've been wrong for a long time. I wrote about my feelings on AI, coding, and the future of software development in my blog. Link below.
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On LLMs and PhDs: To me the notable thing about China's DeepSeek is not technical innovation -- it's a good product, but no brilliant or even clever advances IMO -- is that apparently most of the engineers working on it have only Bachelor's degrees. I'll take a sharp Bachelor's person over a plodder PhD any day. But there is even more to the point that hiring only PhDs may be a poor strategy for those in the LLM business. One often sees discussion of an LLM's ability to solve problems from the Math Olympiad and similar contests. Though the LLMs' ability to do so says a lot about the math contests -- those math problems have more of an underlying pattern to mimic than people will admit to themselves -- the focus on the contests is a reflection of the PhD mentality, "Wouldn't be cool to do well in the Olympiads?" I'd rather the LLMs do well on questions like, "Please explain how governments create money." I actually gave that query to several major LLMs just now, and I wasn't really happy with any of their responses. Optimizing a system for trait A typically means compromising on trait B, even if all this occurs unconciously. I do agree that the advent of LLMs has huge potential to help advance the status of humanity. But maybe you LLM companies might consider hiring some people who have only a Bachelor's or Master's?
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Replying to @farmaceuticsbcn
@farmaceuticsbcn he anat a la Farmacia a  comprar Atorvastatina i Naproxeno, sense receptes perquè @mufaceoficial no envia talonaris des de fa mes d’un mes. A la meva Farmacia no me’ls han venut sense recepta, però a  la del costat sí. Qui ho ha fet malament?
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I posats a preguntar, quin sentit te que la mateixa Farmacia no et vengui Ibuprofeno de 600 mg però si de 400mg, del qual te’n pots prendre tants com vulguis?
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My deep learning course @unige_en is available on-line. 1000+ slides, ~20h of screen-casts. Full of examples in @PyTorch. fleuret.org/dlc/ And my "Little Book of Deep Learning" is available as a phone-formatted pdf (400k downloads!) fleuret.org/lbdl/
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Alex Sanchez Pla retweeted
Some people today are discouraging others from learning programming on the grounds AI will automate it. This advice will be seen as some of the worst career advice ever given. I disagree with the Turing Award and Nobel prize winner who wrote, “It is far more likely that the programming occupation will become extinct [...] than that it will become all-powerful. More and more, computers will program themselves.”​ Statements discouraging people from learning to code are harmful! In the 1960s, when programming moved from punchcards (where a programmer had to laboriously make holes in physical cards to write code character by character) to keyboards with terminals, programming became easier. And that made it a better time than before to begin programming. Yet it was in this era that Nobel laureate Herb Simon wrote the words quoted in the first paragraph. Today’s arguments not to learn to code continue to echo his comment. As coding becomes easier, more people should code, not fewer! Over the past few decades, as programming has moved from assembly language to higher-level languages like C, from desktop to cloud, from raw text editors to IDEs to AI assisted coding where sometimes one barely even looks at the generated code (which some coders recently started to call vibe coding), it is getting easier with each step. I wrote previously that I see tech-savvy people coordinating AI tools to move toward being 10x professionals — individuals who have 10 times the impact of the average person in their field. I am increasingly convinced that the best way for many people to accomplish this is not to be just consumers of AI applications, but to learn enough coding to use AI-assisted coding tools effectively. One question I’m asked most often is what someone should do who is worried about job displacement by AI. My answer is: Learn about AI and take control of it, because one of the most important skills in the future will be the ability to tell a computer exactly what you want, so it can do that for you. Coding (or getting AI to code for you) is a great way to do that. When I was working on the course Generative AI for Everyone and needed to generate AI artwork for the background images, I worked with a collaborator who had studied art history and knew the language of art. He prompted Midjourney with terminology based on the historical style, palette, artist inspiration and so on — using the language of art — to get the result he wanted. I didn’t know this language, and my paltry attempts at prompting could not deliver as effective a result. Similarly, scientists, analysts, marketers, recruiters, and people of a wide range of professions who understand the language of software through their knowledge of coding can tell an LLM or an AI-enabled IDE what they want much more precisely, and get much better results. As these tools are continuing to make coding easier, this is the best time yet to learn to code, to learn the language of software, and learn to make computers do exactly what you want them to do. [Original text: deeplearning.ai/the-batch/is… ]
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💣 Los modelos predictivos NUNCA están realmente validados 💥 👉 La validación externa es solo una "foto" en un momento y lugar específico. 👉 Según Van Calster et al. (2023), un modelo de predicción nunca es universalmente válido porque: 🧵👇 #stats #datascience #ML #analytics
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Alex Sanchez Pla retweeted
Big news - part 1 of the 2025 Canadian Bioinformatics Workshop Series has arrived! Learn more and apply here: bioinformatics.ca/workshops/…
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Alex Sanchez Pla retweeted
i am about to teach a new applied linear algebra course at @PennEngineers, meant for datasci/ML/AI. to support the class, i've written a book... [see below for links to text]
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Alex Sanchez Pla retweeted
Lovely article by @deevybee from 1990 (!) discussing Type 1 error inflation due to p-hacking (simulating a 40% Type 1 error rate based on realistic flexibility), bad measurement, bad theory, and proposing prespecifying tests and replications as solutions. tandfonline.com/doi/abs/10.1…
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Alex Sanchez Pla retweeted
Confidence intervals are confusing intervals. The reason is because they tell us something about what happens across many confidence intervals, not in any single confidence interval. In the long run, 95% of 95% CI contain a population parameter. 1/n
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Alex Sanchez Pla retweeted
Digital book series of the day by Anthony W. Knapp (born December 2, 1941): * Basic Algebra * Basic Real Analysis * Stokes's Theorem and Whitney Manifolds * Advanced Algebra * Advanced Real Analysis * Lie Groups Beyond an Introduction Available at author's website: math.stonybrook.edu/~aknapp/…
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