Sara Scinicariello (@SaraScini) profile picture

Sara Scinicariello

@SaraScini

Doctoral Researcher at @MaxPerutzLabs @viennabiocenter 🧬

 Vienna, Austria
Joined May 2012
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New in @eLife by the @versteegga lab w/ first author @SaraScini! TTP is a critical player in the resolution of the inflammatory response. The team identified HUWE1 as a strong regulator of TTP proteasomal degradation. Read more: bit.ly/41qJwVj @univienna
Image from Max Perutz Labs Vienna (@MaxPerutzLabs)
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Dr. Michael Bauer takes over as new Chief Executive Officer of QUANTRO. Michael is a seasoned biotech entrepreneur, with the right set of skills to realize the potential of our platform and drive our growth even further. Welcome Michael! Read more - PR: bit.ly/3MxfhaH
Image from QUANTRO Therapeutics GmbH (@QuantroTx)
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Gijs Versteeg (@versteegga) profile pictureGijs Versteeg@versteegga24 Mar 2023
Our paper on how the E3 ligase HUWE1 controls the degradation of one of the main cellular inflammation inhibitors -TTP- is out in @eLife. Fantastic efforts of @sarascini, in collaboration with the labs of @clausen_lab, Pavel Kovarik, and @johannes_zuber. doi.org/10.7554/eLife.83159
HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation

HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation

HUWE1 indirectly mediates the return to cellular homeostasis after pro-inflammatory responses, which it does by controling the stability of the immune suppressor tristetraprolin.

elifesciences.org
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Gijs Versteeg (@versteegga) profile pictureGijs Versteeg@versteegga11 Oct 2022
Check out our latest preprint from Milica Vunjak et al. in collaboration with the labs of @johannes_zuber and Thomas Decker! We describe how the E3 ligase SPOP recognizes conserved degrons in the immune TF IRF1, and targets it for proteasomal degradation. biorxiv.org/content/10.1101/…
SPOP targets the immune transcription factor IRF1 for proteasomal degradation

SPOP targets the immune transcription factor IRF1 for proteasomal degradation

Adaptation of the functional proteome is essential to counter pathogens during infection, yet precisely timed degradation of these response proteins after pathogen clearance is likewise key to...

biorxiv.org
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Sketching Science (@sketchscience) profile picture
Sketching Science@sketchscience10 Sep 2022
DNA Enzymes explained with earphones 🧬🎧
Image from Sketching Science (@sketchscience)
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Happy to finally share my PhD work. Thanks to all the people involved! It was great to collaborate with you!🧬
Gijs Versteeg (@versteegga) profile pictureGijs Versteeg@versteegga30 Aug 2022
Excited to share our latest prep-print by @sarascini and the labs of @clausen_lab, Pavel Kovarik, and @johannes_zuber! Check out how the E3 ligase HUWE1 controls the proteasomal degradation of one of the main negative regulators of inflammation, TTP. biorxiv.org/cgi/content/shor…
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