Moveo Ergo Sum/Happiness is 'perceived' energy efficiency/Internist interested in biology, behavior & movement
Glenview, Illinois
Joined April 2012
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An assumption of frictionless slide is not going well with a cycloid.
A cycloid has a contact point on the ground & friction makes the bead/ball rotate.
G pulling w/ friction rotates bead/ball.
Quicker initial rotation (accel) by front void under G makes brachistochrone curve.
Not just food, filtration/oxygen/water flow are also important to enable to achieve limited water use.
Maintenance is important/expensive to manage limited amount of water.
During problems with maintenance, fish death has to be avoided.
Human w/ large # of cells is no exception.
One tank can produce 3000-4000kg of fish!#RASFishFarming #aquacultureequipment #fishfarming #recirculatingaquaculture #AquacultureTechnology
IL-6 by viral infection signals a huge catabolic ps: stress/starvation.
Large amounts of lactate producing cells are needed of the demand is high.
Infection is rare at cancer sites.
Dementia (cog failure) is rare w/ cancer.
Lactate is prime fuel for brain.
teapawt.org/ShiningScience/status/…
COVID-19 and Flu May Awaken ‘Sleeping’ Cancer Cells Hiding in the Lungs for Years
A study published in Nature has uncovered a disturbing possibility: common respiratory infections, including COVID-19 and influenza, may awaken dormant breast cancer cells hiding in the lungs, allowing them to begin growing again.
When breast cancer spreads, some cancer cells can travel to distant organs, including the lungs. Even after successful treatment of the original tumor, a few of these cells may remain alive but inactive for years. They can stay hidden without causing symptoms, making it seem as though the cancer is gone.
But researchers have discovered that a severe respiratory infection may change that situation.
When the body fights a virus, it releases inflammatory signals to defend itself. One of these signals, a protein called interleukin-6 (IL-6), appears to play a key role in waking up dormant cancer cells. Once activated, these previously silent cells can multiply and begin forming new tumors.
The most unsettling part? The researchers also examined human health data and found that breast cancer survivors who contracted COVID-19 had a higher risk of developing lung metastases. This supports the laboratory findings, although it does not prove that infection alone caused the cancer to return.
Scientists are now investigating whether blocking IL-6 or controlling the harmful effects of inflammation could help prevent these hidden cancer cells from becoming active again.
This does NOT mean that catching the flu or COVID-19 will inevitably cause cancer to return. More research is needed to understand the risks and determine whether treatments targeting inflammation can protect cancer survivors.
Still, the discovery raises a fascinating and important question: Could cancer sometimes return not because new cancer cells appear, but because cells that survived treatment have been waiting for the right signal to wake up?
Source: DeGregori, J., Aguirre-Ghiso, J. A., Rincon, M., & Vermeulen, R. (2025). Respiratory viral infections awaken metastatic breast cancer cells in lungs. Nature.
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Toxic virus to control population in major stress/starvation.
Autophagy/apoptosis for clean recycling needs energy input.
W/ poor housekeeping,⬆️energy demand for catabolism is disastrous to cause necrosis of cells of incomplete clean up:⬆️cytokine/storm.
teapawt.org/Innov_Medicine/status/…
Cytokine Storm
nejm.org/doi/full/10.1056/NE…
Clinical Presentation of Cytokine Storm
The clinical presentation of cytokine storm, or cytokine release syndrome (CRS), can manifest in various ways. Here are 10 common features observed in cytokine storm: Fever, Systemic Inflammation, Hemodynamic Instability, Respiratory Distress, Organ Dysfunction, Coagulopathy, Elevated C-reactive protein (CRP) and Ferritin levels, Lymphopenia, Skin Manifestations, and Multiorgan Failure.
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Mass makes muscles move.
Rigid watermill moves by mass (water) placed in buckets.
Muscles can act as rigid body upon (eccentric) tightening.
Placing right amount of mass in right place at right time.
The system (muscles) can be run smooth or disorganized to break down.
#Bears Caleb Williams - Concern for hamstring. Reaction suggests high severity
If strained w/o rupture, avg ~6 wk timeline
Tendon rupture typically = season-ending
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Incomplete follow-thru of rt leg mass upon lt knee extension: incomplete Lombard.
Failure to load wt over 'HAMSTRING-PULLEY' system will surge force to lt hamstring w/ loosening of calf muscle: circuit-overload to fail the entire lifting (knee-ext) system.
teapawt.org/FanDuelSNBraves/status…
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W/ friction (generated by loading force: own wt by gravity), forwarding mass (swing leg mass & upper body mass) can extend the stance knee by force transfer via hamstring muscles (like pulley).
Using own wt to lift own wt d/t friction by own wt under G.
teapawt.org/TheFigen_/status/17566…
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Heart can pump only what it receives.
Venous return/VR mainly by wt-bearing activity & quiet breathing.
Resp muscles do dual-function: resp/posture.
Physical activity, if well-engaged, dual fn can be maximized for wt-bearing/resp suction pump: VR.
#Lactateshuttle for brain/heart.
Stoked to already have > 15 submissions to our Special Collection:
Physical Activity & Mental Health: From Mechanisms to Global Implementation go.nature.com/4p5o3wD
Thanks to our amazing team of guest editors - @BrendonStubbs23 @KMachaczek @simon_rosenbaum & Dr.P.S.Indu
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Rhythmic music helps predictability.
W/ practice, easier to do this wt-bearing action: quieter brain & active muscle pump to ⬆️venous return/⬆️cardiac output w/⬇️systemic arterial resistance.
⬆️ tissue perfusion.
⬆️Predictability for mental health.
teapawt.org/ThoNg676733/status/205…
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Hunting/escaping can't be choreographed.
Top-down cerebral command won't work d/t sensory-motor delay.
Accurate prediction via Bayesian selection is necessary.
Errors in Bayesian selection/prediction can be mitigated by environmental control.
teapawt.org/NatureChapter/status/2…
Human interaction & adaptation to a new environment can be stressful.
Monkeys & humans developed a delicate torso control a long time ago.
Stiff torso from stress limiting ventilation (resp venous suction pump) can be harmful.
Softening torso to enhance pump by various methods.
Monkeys 'learn to eat soil to cope with junk food' bbc.in/4mGTiOm
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Smokers often maintain oral 'suction' behavior when cigarette already left their mouth: enhanced inspiratory suction pump for ⬆️central circulation.
What can replace smoking habit for next generations w/ more stress & anxiety?
⬆️Eating for ⬆️vagal tone?
teapawt.org/BBCNews/status/2046527…
Smoking ban for people born after 2008 in the UK agreed bbc.in/4cEfrbq
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A simple appetite suppression won't be an answer to prevention of obesity: eating helps circulation via vagal nerve stimulation, so brain fn.
Focus for obesity tx needs to be shifted to mechanics of stress tone, not suppression of appetite or metabolism.
doi.org/10.1038/s41398-023-0…
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