@sheeradar
adarlab.com
Joined November 2015
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17Media
My PhD home…
raz sauber - רז זאובר
@raz_sauber_15 Jun 2025
This is the most Israeli thing I’ve seen. Taken at the Weizmann Institute of Science, following the Iranian attack.
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New paper alert! The epigenetic landscape shapes smoking-induced mutagenesis by modulating DNA damage susceptibility and DNA repair efficiency academic.oup.com/nar/article….

The epigenetic landscape shapes smoking-induced mutagenesis by modulating DNA damage susceptibility...

Abstract. Lung cancer sequencing efforts have uncovered mutational signatures that are attributed to exposure to the cigarette smoke carcinogen benzo[a]pyr

academic.oup.com
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So proud of @ElishevaHeilbr1 for leading this project. It was wonderful working on this collaboration with @danatse_ @CohenYuval2 Hana Wasserman and @RalucaGordan.
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It was really cool to see that repair efficiency is a stronger influence than damage-sensitivity on the final mutational profile. But still: It's best not to smoke!
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Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24! You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond Registration will open by June 2025
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How was my day?
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Things you do when you don't have a time machine. Congrats @lirancarmel and @meshorer1
Liran Carmel@lirancarmel20 Nov 2024
Our latest paper is out in @NatureEcoEvo: Inferring DNA methylation in non-skeletal tissues of ancient specimens. A major challenge in studying DNA methylation in ancient samples is that it is tissue-specific. 1/11
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Thrilled to share our latest article in Trends in Genetics! Ever wondered why RNA processing factors are recruited to DNA DSBs? We propose two explanations that shed novel insights into the functional significance of RNA processing factors at DSB sites. eur01.safelinks.protection.o…
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New preprint! A fun collaboration lead by Yaara Negev Korem, with Ron Kohen and Dan Gibson from @PharmacyHUJI and Ori Wald from @Hadassah_Med ! We synthesized a novel cisplatin-based prodrug, in which cisplatin is fused to two KDAC inhibitors. Check it out: @IMRIC_HUJ @Hujimed
bioRxiv Molecular Biology@biorxiv_molbio3 Nov 2024
A Novel Cisplatin-Based Prodrug Inhibits Lysine Deacetylases, Suppresses Nucleotide Excision Repair, and Overcomes Resistance biorxiv.org/cgi/content/shor… #biorxiv_molbio
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The drug creates more DNA damage and kills cancer cells more efficiently than cisplatin. It extended survival in a mouse cancer model, and cells did not develop resistance after long-term exposure.
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KDAC inhibition increases chromatin accessibility – but this isn’t why there’s more DNA damage... Also: despite the increased accessibility, nucleotide excision repair is repressed. Always fun to get results you didn’t expect!
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🚨 Please RT Thrilled to share our new study in turquoise killifish, revealing that mutating cGAS-STING can rescue key defects in DNA damage repair syndromes! Findings offer a potential therapeutic target, with possible implications for aging. Read here: t.ly/agJFD
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Back home after a fantastic #EMGS meeting in Palm Springs.
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Headed home after an absolutely fantastic #Grcmutagenesis meeting.
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Sheera Adar retweeted
Yotam Drier@yotam_d30 May 2024
Our paper is now official out, see the new and improved version at: science.org/doi/10.1126/scia… Congratulation to the wonderful @EdenEngal_, @MaayanSalton and team.

DNMT3B splicing dysregulation mediated by SMCHD1 loss contributes to DUX4 overexpression and FSHD...

SMCHD1 loss drives FSHD pathogenesis by disrupting DNMT3B splicing, leading to D4Z4 hypomethylation and DUX4 overexpression.

science.org
Yotam Drier@yotam_d1 Mar 2023
Happy to report our latest results on the role of SMCHD1 in facioscapulohumeral muscular dystrophy (FSHD). A very close and fun collaboration with @MaayanSalton, this work was led by our amazing joint MD/PhD student @EdenEngal_ 1/2 biorxiv.org/cgi/content/shor…
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Our paper is now officially out: nature.com/articles/s41467-0… A great collaboration with @JeffreyAFarrell, and a major effort by our own @fishman_lior
Michal Rabani@MichalRabani26 Apr 2023
How do pluripotent cells assume specialized molecular identities within an embryo? Check out the lab’s first preprint! A great collaboration with @JeffreyAFarrell and a major effort by our own Lior Fishman (1/12) biorxiv.org/content/10.1101/…

Single-cell temporal dynamics reveals the relative contributions of transcription and degradation...

During embryonic development, pluripotent cells assume specialized identities by adopting particular gene expression profiles. However, systematically dissecting the underlying regulation of mRNA...

biorxiv.org
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Making nucleosome figures for a grant on a Saturday morning. Family member #1: "Hey look, it's a macaroon!", #2: "No it's a menthos!" Back to the drawing board.
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Nice to see this out. Congrats to @HibaHassanain @danatse_, @tamarhaco and the rest of the (twitterless) team! Based on the method first developed by @BenVanHouten2 and Joel Meyer: An easy-to-implement DNA damage detection method we hope will be useful sciencedirect.com/science/ar…
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🔥🔥🔥Our review article on 🧬🧬🧬Genome Instability and DNA Repair in Somatic and Reproductive Aging @spanier55 and @SiyaoWang1005 @CECAD_ @MPIAGE @imbmainz @UKKoeln @UKKoeln annualreviews.org/doi/full/1…

Genome Instability and DNA Repair in Somatic and Reproductive Aging

Genetic material is constantly subjected to genotoxic insults and is critically dependent on DNA repair. Genome maintenance mechanisms differ in somatic and germ cells as the soma only requires...

annualreviews.org
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