Microbiologist by day. Coffee enthusiast by midday. ☕
Boston, MA
Joined October 2016
- Tweets65
- Following199
- Followers100
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Trever Smith retweeted
Congratulations to the multi-centered team from @TuftsMedSchool, @tuftsvet, @NUFeinbergMed, @MaineHealth, @MassGenHospital, and the @TuftsMedicine health system on their $20.7M grant from @NIH to study what leads to #ChronicLyme.
The largest NIH-backed study yet, it aims to unlock the mysteries behind long-term #Lyme symptoms.
newswise.com/articles/large-…
Super excited to be starting this work! Big thanks to @AldridgeLab, @TuftsLyme, and @petedoesscience for all their helpful feedback and support during the writing and submission process!
.@trevercsmith of @TuftsMedSchool has been named winner of the #BAL 2024 Emerging Leader Award. Dr. Smith will receive $150K for his pioneering research on combination therapies for persistent #Lymedisease. His work aims to create a first-of-its-kind drug interaction compendium to better target persistent Borrelia burgdorferi (Bb) infections. This could lead to more effective treatments, offering new hope for those w/ persistent #Lyme.
Read the full release here: bit.ly/4d3Slu1
#Lymediseaseresearch #Lymetherapeutics
Trever Smith retweeted
How does M. tuberculosis respond spatiotemporally to the host microenvironment & influence infection outcome? Grantee Shumin Tan tests her hypothesis using single-cell resolution.
🥳Congrats Dr. Tan! @TuftsUniversity
🙏#HFScout Dianne Newmann @Caltech
2/6
Trever Smith retweeted
late to celebrate this because i am BAD AT TWITTER but thanks to @BayAreaLyme, who gave us an award to keep developing our diagnostic test!
Congratulations to Nichole Pedowitz and @TuftsLyme researcher Peter Gwynne for being this year's selections for the Bay Area Lyme Foundation's Emerging Leader Award. We look forward to great things from both of them. bayarealyme.org/our-research…
Trever Smith retweeted
We are looking for a postdoc to work with our drug combinations team to design multidrug therapies for TB. Please write me if you have an adventurous and team-oriented spirit, attention to detail, and an interest in quantitative biology and machine learning. Please RT!
Trever Smith retweeted
Excited to share our paper now out in @NatureMicrobiol nature.com/articles/s41564-0…. We used our CG screening and clinical Mtb genomics method to reveal novel mechanisms of drug resistance and identify a new opportunity to potentially use clarithromycin in TB treatment
Trever Smith retweeted
My lab is interviewing for a Research Assistant position to work on antibiotic resistance and bacterial pathogenesis. Candidates can have 0-10 years post Bachelor's degree experience. Position promotes training and career growth. If interested, apply to:
jobs.tufts.edu/jobs/16788?la…
Trever Smith retweeted
A little something for the academic crowd youtu.be/dx71U3u--qU
Trever Smith retweeted
Our paper about lipids and a (possible) new diagnostic test for Lyme disease got published! Thanks @jclinicalinvest and @TuftsLyme
jci.org/articles/view/152506
Trever Smith retweeted
Lab on Gingerbread, from Shumin Tan's lab. A complete and compact system to plasmid-transform bacteria, with results in an hour.
If things don't work out, you can always eat your results. Or eat your equipment.
youtu.be/21dS8d74SCs via @YouTube
Trever Smith retweeted
Excited to share that Jonah, @yonaneg, and Nhi’s new paper is up on bioRxiv. We collaborated with the Artem Sokolov @HiTSatHarvard to create rulesets that describe how to construct effective drug combinations for #tuberculosis. 1/6
Design principles to assemble drug combinations for effective tuberculosis therapy using interpretable pairwise drug response measurements biorxiv.org/cgi/content/shor… #bioRxiv
Trever Smith retweeted
Kudos to PhD student Yunfei Dai and to a super team-up with @CavaLab_MIMS on our new paper in mBio. Acinetobacter baumannii uses an unexpected enzyme to recycle its peptidoglycan and resist cell wall knocks.
journals.asm.org/doi/10.1128…
Trever Smith retweeted
@tiagobeites et al from the lab found that in Mtb, the lack of etfD results in a block in β-oxidation at the step catalyzed by acyl-CoA dehydrogenases rendering the mutant unable to grow on fatty acids and making the long chain fatty acids bactericidal.
nature.com/articles/s41467-0… – at Manhattan, NY
Trever Smith retweeted
1/ Now out in Cell Reports (open access). Our latest contribution to vacuole guard hypothesis. SdhA loss causes Legionella vacuole disintegration and macrophage pyroptosis. SdhA works by sequestering endocytic regulator, the inositol phosphatase OCRL.
cell.com/cell-reports/fullte…
Trever Smith retweeted
Excited! Final version out now alongside complementary work from @mbogyo @BrettMBabin, both showing the ins and outs of ABPP for Mtb inhibitor discovery. @hirenpMD @armandcognetta @trevercsmith @JefCavalier @canaanlab @AldridgeLab
sciencedirect.com/science/ar…
Shout-out to co-first Mike Li, Hiren Patel and @armandcognetta @trevercsmith @JefCavalier Ivy Mallick for bringing this story to fruition with library screening, ABPP, enzymology, docking, and MorphEUS morphological analysis 2/n biorxiv.org/content/10.1101/…
Trever Smith retweeted
Excited to finally share: Systematic measurement of combination-drug landscapes to predict in vivo treatment outcomes for tuberculosis cell.com/cell-systems/fullte…
Trever Smith retweeted
In high school biology, I was paired up with a boy and told to draw what we thought our baby would look like, and that’s the only genetics lesson I ever had until college. Scientists are rare in rural USA and it can cause a divide.
So I helped with this: sciencedirect.com/science/ar…