@vanRheenen_Lab

@vanrheenenlab.bsky.social Intravital microscopy of tumor initiation, progression, metastasis and therapy resistance.

 Netherlands Cancer Institute
Joined March 2020
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  • Followers1.3K
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📢Dear followers, We are moving to BlueSky! Follow our exciting updates from now on BlueSky platform: @vanrheenenlab.bsky.social
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A wonderful News & Views article accompanies our recent paper @Nature ! 😃 nature.com/articles/d41586-0… Curious why timing matters for breast cancer treatments? Tune into the Nature podcast: "Why they might work best just after your period." 🎙️ youtube.com/watch?v=vg2_I2Uj…

What is the best time of the month to treat breast cancer?

Nature - Sensitivity to chemotherapy is affected by hormonal fluctuations.

nature.com
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Our paper on how the oestrous cycle influences chemotherapy sensitivity is featured in Dutch news! Check it out! #ScienceNews #Chemotherapy nrc.nl/nieuws/2024/12/04/bij…

Bij muizen beïnvloedt de menstruatiecyclus hoe goed chemo aanslaat bij kanker

Kanker: Bestaat er een verband tussen de menstruatiecyclus en de effectiviteit van medicijnen? „Vrouwen voelen continu dat hun cyclus invloed heeft op allerlei processen in hun lichaam.”

nrc.nl
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📢Very excited to share this paper with you! The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy published @Nature . Congratulations to Laura, @ColindaScheele and all the authors for this amazing story. nature.com/articles/s41586-0…

The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy

Nature - In three mouse models of breast cancer, we show reduced responses to neoadjuvant chemotherapy when treatment is initiated during the dioestrus stage, when compared with initiation during...

nature.com
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New paper out 📢Congrats to all authors from Medema and Vooijs lab! sciencedirect.com/science/ar… A novel lineage-tracing tool reveals that hypoxic tumor cells drive tumor relapse after radiotherapy
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📢 Applications for the NKI PhD program open from Jan 1 - Feb 28. Join our international research community in Amsterdam, working in cancer biology, AI research & life sciences with leading scientists and top facilities #PhD #CancerResearch More info: bit.ly/3O4bOjq
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#Cancer-inducing mutations common but most don't result in a tumour. Mechanisms that protect against cancer formation revealed in mammary gland Image captured with @LeicaMicro 📷: @vanRheenen_Lab @vib_ccb @oncodeinstitute @GurdonInstitute in @Nature ➡️: bpod.org.uk/archive/2024/9/1…
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📢van Rheenen lab is looking for an enthusiastic physician-researcher. For more details, check out the links below: nki.nl/careers-study/vacanci… werkenbijavl.nl/vacatures/md… Retweets are appreciated😇
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Van Rheenen Lab retweeted
Mammary Cell News
@MammaryCell4 Sep 2024
Scientific wonders happen when @vib_ccb and @NKI_nl meet. 🤝 Marta Ciwinska, Hendrik Messal, & Hristina Hristova & collaborators uncover the mechanisms that clear mutations drive field cancerization in #mammary tissue. @ColindaScheele @vanRheenen_Lab ✔️ go.nature.com/4dPwSFw
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📰Beautiful news and views article of our latest paper @Nature together with @ColindaScheele lab on #fieldcancerization in the #breast by Ciwinska, Messal, Hristova et al. written by Biancastella Cereser. Read more👇: nature.com/articles/d41586-0…

Breast cancer blocked by multiple natural lines of defence

Nature - Three protective mechanisms limit the ability of cells to form a tumour.

nature.com
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New publication alert🚨🚨🚨Mechanisms that clear mutations drive field cancerization in mammary tissue is out @Nature nature.com/articles/s41586-0… Congratulations all for this great team work! 🎉

Mechanisms that clear mutations drive field cancerization in mammary tissue

Nature - The authors use lineage tracing to map the fate of wild-type and Brca1−/−;Trp53−/− cells in the adult mouse mammary gland, identifying three layers of protection...

nature.com
Colinda Scheele@ColindaScheele4 Sep 2024
Super happy to share that our paper is published in @Nature today! We've discovered how the breast is protected against tumor initiation—though it comes at a cost. 📰Read all about it here: bit.ly/3MSxoa1 🏥@vib_ccb @Onco_KULeuven @NKI_nl @vanRheenen_Lab @BenSimons_Lab
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Check out our recently published paper in collaboration with Andreu and Roca-Cusachs lab!📰Congrats to all authors! journals.biologists.com/jcs/…
GuiGui De Los Reyes@DGuiGui0116 Aug 2024
🚨Paper! We harnessed a mechanosensitive nucleocytoplasmic transport (NT) probe, named Sencyt. We shows that NT responds to mechanical changes in a manner consistent with a role of nuclear membrane tension. In contrast to YAP, there is no response to cell density/confluency 1/3
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Group leader Jacco van Rheenen @VanRheenen_Lab is elected as a new member of the @EMBO “I am truly privileged to be elected.” Read more ➡️ nki.nl/news-events/news/jacc… #research #cancerresearch #biology #embo
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Van Rheenen Lab retweeted
Marcel Hobma@marcel_hobma1 Jul 2024
"Tumoren die uitzaaien zijn nauwelijks te genezen en zijn de belangrijkste doodsoorzaak van kankerpatiënten. Nieuw onderzoek laat zien dat tumoren hun omgeving naar hun hand zetten." Voor @nrcwetenschap mocht ik onderzoek doen naar hoe kanker uitzaait: nrc.nl/nieuws/2024/06/26/een…
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OVHIPEC-1 trial uses tumor microenvironment data to select ovarian cancer patients for hyperthermic intraperitoneal chemotherapy.🧪 Check out our most recent publication in Nature BJC! 📜 nature.com/articles/s41416-0…

Tumour microenvironment characterisation to stratify patients for hyperthermic intraperitoneal...

British Journal of Cancer - Tumour microenvironment characterisation to stratify patients for hyperthermic intraperitoneal chemotherapy in high-grade serous ovarian cancer (OVHIPEC-1)

nature.com
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For one of her experiments, PhD candidate Laura Bornes @hetAVL @uniutrecht once spent 43 hours hunched over the microscope. Her goal: uncovering the behaviors of cells. She will defend her thesis on November 3 ➡️ bit.ly/47bw6yO
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Check out our recent publication @ScienceAdvances 🔬📢 science.org/doi/10.1126/scia… Congrats @uceda_rebeca and co-authors for this beautiful work! 😃
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📢🚨Are you interested in joining the @NKI_nl or our lab as a PhD student? Don't miss out this opportunity and apply before 5th of September through the link below 👇 nki.nl/careers-study/student…
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The van Rheenen lab at @uceda_rebeca 's good bye dinner last night! We will miss you in the lab, Rebeca! All the best for your new journey😃Looking forward to your PhD defense 🎓👩‍🎓
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Just obtained your Master's degree in science? 🎓 Turn your knowledge into breakthroughs with our #PhD Program. Work in a stimulating environment, enjoy personal supervision, and be part of a global scientific network. Apply today! bit.ly/44iOcOc
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