Huge thanks to all co-authors & collaborators! Thanks @ebardot for his kind highlight in Nat Cell Biol shorturl.at/Sq1f4 @CNRSbiologie

A central result: cadherin-dependent adhesion contributes significantly to cell-cell tension in C. elegans, with a highly non-linear, Hill-like dependence. Adhesion is not just a small correction to contractility. 6/6

Inside the eggshell, the model predicts morphogenesis quantitatively: anterior compaction is driven by rising cell-medium tension, while P2’s early exclusion reflects high cell-cell contact tension. 5/6

To calibrate inferred tensions, we combined AFM measurements with cortical myosin intensity. AB-lineage cells are more tense than P-lineage cells, and tension rises dynamically through the cell cycle. 4/6

We combined live imaging, contact-angle measurements and tension inference to reconstruct relative surface tensions, then used a 3D active foam model to predict embryo shape over time. 3/6

The early C. elegans embryo is not mechanically uniform. Removing the eggshell, one can observe that at the 4-cell stage, ABa, ABp and EMS compact together, while P2 initially remains partly excluded — revealing dynamic, lineage-specific mechanics. 2/6

Very happy to have this work finally published! How do embryos sculpt their shape? We map the contractile & adhesive forces shaping early C. elegans embryos. With K. Yamamoto @Kazu_YAMAMOTO4 G. Charras' lab and my team shorturl.at/xv7G51/6

Very glad to see this great transatlantic collaborative work published in NCB 🎉! nature.com/articles/s41556-0… Congratulations to all authors: @Henry_de_belly, @andreu_gallen, Eric neiva, @OWeinerLab Funding from MSCA @EU_Commission & @CNRSbiologie

A true computational tour de force by Eric Neiva during his Marie Skłodowska-Curie postdoctoral fellowship in the team, now published in Journal Computational Physics: urlr.me/AuzK86 Congratulations, Eric! @CNRSbiologie Grateful to @EU_Commission for funding support

Conference Alert🚨 16-21 Feb 2025 From Soft Matter to Biophysics @ Les Houches FR t.ly/GXhPL Apply by Dec 15 to explore the latest in soft matter & biophysics, focusing on functional materials & synthetic biology! @karen_alim @Karin__Jacobs @MartinLenz @HerveTurlier

Registrations are open for the Qlife Quantitative Biology spring school on Cell Dynamics in Developmental System March 3-April 04 2025. Great line of talks, lectures and hands-on practicals on omics, image analysis, modeling and inference: shorturl.at/Ygthh

Team retreat in the Pyrenees 📝⛰️🍻

Thanks to all speakers @MarinoArroyo2 @AnjaGeitmann @AlainGoriely Jessica Zhang @aland_lab @GabriellaBioMec Arezki Boudaoud Christophe Godin, Brendan Lane, Robert Nürnberg, Padmini Rangamani, Arnold Reusken, Axel Voigt, Sara Zahedi, Roman Vetter

Our workshop on Finite Elements for Cell & Tissue Morphogenesis at Villa Clythia @caescnrs was a great success ! Congratulations to @ericnumerics for the perfect organisation and looking forward to a next edition.

@HerveTurlier @cavankatenaugh @CharrierLab @sneha_arao @LenartLab @Vane_barone @Chema_MD @sdebuyl @Alex_Mc_Dougall @HitoyoshiYasuo

Our workshop on early embryo morphogenesis in Villefranche-sur-mer was a blast 💥 Thanks to all participants for the lively & friendly atmosphere, @RDumollard for co-organising and to @biodev_vlfr for the great welcome & fantastic setting. Looking forward to see you all again !

An interesting perspective article in Nature by @eisensteinium on the forces that sculpt embryos and how to measure them, highlighting our 3D tension inference method foambryo by @SachaIchbiah & @HerveTurlier nature.com/articles/d41586-0…