@wegmor

Mastodon: @mowe@social.lol

 Stockholm, Sweden
Joined December 2016
  • Tweets220
  • Following441
  • Followers171
19Media
In our new preprint, we show that Sst+ GPi is more anatomically complex than previously described, and that its role in behavioral flexibility is in action execution, not outcome evaluation. w/ @sahrlund @SkaraVasiliki @fuzikjanos @iaklaz @meletislab biorxiv.org/content/10.1101/… 1/8
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High-throughput all-optical postsynaptic plasticity map navigates connectome-guided Voltage-Seq biorxiv.org/cgi/content/shor… #biorxiv_neursci
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this paper really struck a nerve... nature.com/articles/s41586-0…
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Book the day! The 2nd SWEBAGS basal ganglia conference will be next November 30th, 2022. The registration is already open!! If you want to present your research either orally or as a poster, the abstract submission is open until September 30th, 2022. conference2022.swebags.ebrai…
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Moritz Weglage retweeted
Kevin Mizes@KevinMizes14 Jun 2022
Thrilled to share my graduate work with PI @BOlveczky and co-authors @Jack_W_Lindsey & @seanescola: 'piano playing' rats! tl;dr - striatum is needed to produce automatic but not flexible sequences, but it codes for & controls low-level kinematics for both doi.org/10.1101/2022.06.13.4…
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Moritz Weglage retweeted
Marie Carlén@CarlenLab25 May 2022
Right now: Moritz Weglage @wegmor in the Meletis lab @meletislab to nailing of his thesis ’A critic in action? A functional examination of the striato-pallido-habenular circuit’!! 💥. Defence: June 10. @karolinskainst @StratNeuro Great work Moritz!!
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Very happy to share @AnTokarska Ania’s PhD paper, just published @CellReports! We used Chrna2-Cre mice (K Kullander @UU_University) to study striatal interneurons expressing the nicotinic α2 receptor subunit. Inspired by work from @JTep & @Maxime_Assous cell.com/cell-reports/fullte…

GABAergic interneurons expressing the α2 nicotinic receptor subunit are functionally integrated in...

Tokarska and Silberberg characterize the cellular and circuit properties of striatal interneurons expressing Chrna2, the gene encoding for the nicotinic α2 receptor subunit. Using multineuron...

cell.com
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Very excited to share our new preprint! Using whole-cell patch-clamp in awake mice, we reveal that sensory responses in the dorsolateral striatum are modulated by motor activity in a dopamine-dependent manner. @RobertodelaTor, Maya Ketzef, @SilberbergGilad biorxiv.org/content/10.1101/…

Sensory responses in dorsolateral striatum are modulated by motor activity in a dopamine-dependent...

The dorsolateral striatum (DLS) receives excitatory inputs from both sensory and motor cortical regions and is involved in sensory and motor functions. In cortical regions, sensory responses are...

biorxiv.org
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Sst+ GPi output neurons provide direct feedback to key nodes of the basal ganglia and drive behavioral flexibility. biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Instead, in task-engaged expert-level mice, Sst+ GPi activity became suppressed during the choice phase. After reversal, as mice returned to a more flexible behavioral state and adapted to the reversal, Sst+ GPi activity became elevated in the choice phase. 7/8
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We propose that the Sst+ GPi neurons drive behavioral flexibility by counteracting habitual or compulsive choices, and that this function emerges via GABA/Glutamate feedback to key nodes of the behavioral control circuits of the basal ganglia and the LHb. Thanks for reading! 8/8
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Moritz Weglage retweeted
Anders Nelson@AndersMNelson4 Nov 2021
How can a *single class* of neurons with access to most motor control regions help coordinate movement? Find out in our ✨freshly dropped✨ paper, where we reveal the collaborative organization of corticospinal projections through the nervous system. nature.com/articles/s41593-0…
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Moritz Weglage retweeted
XKCD Comic
@xkcdComic26 Oct 2021
Slope Hypothesis Testing xkcd.com/2533/ m.xkcd.com/2533/
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Moritz Weglage retweeted
Marie Carlén@CarlenLab14 Oct 2021
Right now, Dinos Meletis @meletislab is installed as Professor of systems neuroscience at @karolinskainst!! 🎉🥂🎶
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Moritz Weglage retweeted
Dmitry Kobak@hippopedoid13 Sep 2021
I am late to the party (was on holidays), but have now read @lpachter's "Specious Art" paper as well as ~300 quote tweets/threads, played with the code, and can add my two cents. Spoiler: I disagree with their conclusions. Some claims re t-SNE/UMAP are misleading. Thread. 🐘
Lior Pachter@lpachter27 Aug 2021
It's time to stop making t-SNE & UMAP plots. In a new preprint w/ Tara Chari we show that while they display some correlation with the underlying high-dimension data, they don't preserve local or global structure & are misleading. They're also arbitrary.🧵biorxiv.org/content/10.1101/…
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