@xtalmountain

Structural biologist with interests in cancer therapeutics, big data science & molecular art! Tweets are my own.

 Mississauga, Ontario
instagram.com/xtalmountain/
Joined December 2018
  • Tweets168
  • Following218
  • Followers111
4Media
His doctors gave him 2 or 3 months. A new early-stage Toronto cancer treatment, invikafusp alfa (a first-in-class, bispecific, dual T cell agonistic antibody), has been a 'lifesaver' thestar.com/news/canada/his-… via @torontostar

His cancer gave him just months to live. A new early-stage Toronto treatment has been a 'lifesaver'...

Although most investigational drugs fail to pass clinical trials, experts view invikafusp alfa with cautious optimism.

thestar.com
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Free link to this article: thestar.com/gift-redeem?t=4b…

Gift-redeem

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This cancer drug is saving lives. It's also threatening to break Canadian health-care budgets thestar.com/news/investigati… via @torontostar #medicine #cancer #healthcare

This cancer drug is saving lives. It’s also threatening to break Canadian health-care budgets

Canada spent nearly $800 million in 2023 on Keytruda. A joint investigation reveals how its steep price strains public healthcare budgets.

thestar.com
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Noboru Ishiyama retweeted
André Picard@picardonhealthFeb 24
The challenge of whether or not to fund promising new drugs. It’s not enough for a treatment to work, it has to work well and provide value for money, by @picardonhealth theglobeandmail.com/opinion/… via @GlobeDebate

Opinion: The challenge of whether to fund promising new drugs

A new Alzheimer’s drug shows that Canada is going to need guiding principles for funding decisions

theglobeandmail.com
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Servier bags a Black Diamond in the rough. My quick take on today's $BDTX deal via @ApexOnco oncologypipeline.com/apexonc…

Servier bags a Black Diamond in the rough

apexonco.com
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Noboru Ishiyama retweeted
Gottardi Lab@GottardiLab10 Jan 2025
AT LONG LAST… The essential #adherensjunction mechanosensitive protein alpha-catenin is required for #cytokinesis fidelity. We credential a previously defined (but poorly understood) abscission factor in this process, LZTS2. 🧵1/12 rupress.org/jcb/article-abst…

α-Catenin force-sensitive binding and sequestration of LZTS2 leads to cytokinesis failure

This paper shows how epithelial cell–cell junctions play a critical role in the fidelity of cell division, where persistent unfolding of the mechanosensiti

rupress.org
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In @JCellBiol, Wang, Yemelyanov et al. @GottardiLab @NorthwesternMed find that the force-sensitive cell-cell #adhesion component alpha-catenin is required for #cytokinesis fidelity through LZTS2. hubs.la/Q031WQmd0 @PMResearch_UHN @xtalmountain @gingraslab1 #CellDivision
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Wang, Yemelyanov et al. @GottardiLab @NorthwesternMed find that the force-sensitive cell-cell #adhesion component alpha-catenin is required for #cytokinesis fidelity through LZTS2. hubs.la/Q031WKcm0 @PMResearch_UHN @xtalmountain @gingraslab1 #CellDivision
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Noboru Ishiyama retweeted
Simon Duerr@simonduerr1 Oct 2024
There is a new tool on BioIcons to turn any protein (in PDB format) into a 2D vector illustration in SVG format. You can upload any PDB file or import from PDB, AlphaFoldDB or ESMFoldDB. Feedback welcome :) bioicons.com/pdb2vector/
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Revolution, interrupted: Why AI has failed to live up to the hype in drug development /via @globeandmail theglobeandmail.com/business…

Revolution, interrupted: Why AI has failed to live up to the hype in drug development

One of the promises of machine learning was better drugs, faster. A decade in, that has yet to happen

theglobeandmail.com
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"A drug molecule needs to bind to a protein in order to treat disease, and finding a match is a ridiculously complicated problem, in part because proteins can assume different shapes and structures. ... AI is of little help."
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Latest from Congruence Tx: arxiv.org/abs/2408.12519
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How Jim Carrey helped Raptors icon DeMar DeRozan face depression thestar.com/sports/raptors/h… via @torontostar

How Jim Carrey helped Raptors icon DeMar DeRozan face depression

This excerpt from the new book “Above the Noise: My Story of Chasing Calm” reveals the hours before DeRozan sent out the tweet that changed the NBA conversation on mental health.

thestar.com
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OPIG DPhil student @GemmaLGordon led work to build and analyse "PLAbDab-nano: a database of camelid and shark nanobodies from patents and the literature". Just released on bioRxiv and available as an OPIG webapp: Preprint: biorxiv.org/content/10.1101/… Webapp: opig.stats.ox.ac.uk/webapps/…

PLAbDab-nano: a database of camelid and shark nanobodies from patents and literature

Nanobodies are essential proteins of the adaptive immune systems of camelid and shark species, complementing conventional antibodies. Properties such as their relatively small size, solubility and...

biorxiv.org
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Noboru Ishiyama retweeted
Yoshitaka Moriwaki@Ag_smith17 Jul 2024
🎉 New formula Coot 1.1.09 in Brewsci/bio for Linux and macOS! ℹ️ Crystallographic Object-Oriented Toolkit 🍺 brew install brewsci/bio/coot #Bioinformatics
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bbc.com/news/world-australia…

Richard Scolyer: Melanoma doctor's high-stakes gamble to treat his brain cancer

Richard Scolyer hopes the life-saving melanoma research he pioneered could treat his brain tumour.

bbc.com
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Noboru Ishiyama retweeted
Lorenzo Casalino@LCasalino889 Dec 2022
In 2018, I started my journey at @RommieAmaro's lab working on mesoscale simulations of influenza virus. After ~5 years in the making, I'm happy to share that the paper is now published in @ACSCentSci! pubs.acs.org/doi/full/10.102… Instead of a 🧵, I made a trailer 🎞️🎥! Sound ON 🔊
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Here is how you can add protein structures from PyMOL as interactive 3D models in PowerPoint: 1) In PyMOL, export VRML2 file. 2) Convert file from VRML2 to glTF format in Blender. 3) Insert as 3D model in PowerPoint. That's it! For more info: youtu.be/0DOZ0jj289k
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Noboru Ishiyama retweeted
Gottardi Lab@GottardiLab27 Aug 2023
New on BioRxiv: The essential adherens junction mechanosensitive component alpha-catenin is required for cytokinesis fidelity. We also credential a previously defined (but poorly understood) abscission factor in this process, LZTS2.
bioRxiv Cell Biology@biorxiv_cellbio27 Aug 2023
α-catenin mechanosensitivity as a route to cytokinesis failure through sequestration of LZTS2 biorxiv.org/cgi/content/shor… #biorxiv_cellbio
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Noboru Ishiyama retweeted
NCBI@NCBI7 Jan 2023
New preprint publication on ElasticBLAST, a cloud native application that performs #BLAST searches for a few to millions of query sequences in the Cloud! ow.ly/nScr50Mjwpw

ElasticBLAST: Accelerating Sequence Search via Cloud Computing

Background Biomedical researchers use alignments produced by BLAST (Basic Local Alignment Search Tool) to categorize their query sequences. Producing such alignments is an essential bioinformatics...

biorxiv.org
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