A learning developmental biologist in the Desplan lab at NYU. An MD. Opinions are my own. He/his. Also on @ycchen_tw@drosophila.social/ycchentw.bsky.social

New York, NY
Joined December 2017
Congratulations Sromana!!
Very excited (and relieved 😅) to share that I’ve been awarded an @NIH #NEI K99/R00 Pathway to Independence Award! 🎉 This award will support my research on the molecular mechanisms that guide visual map formation during development and kickstart the next phase of my career.
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I am giving a talk this Tuesday at @Harvard Neural Development Club about our how minimal memory of spatial patterning confers flexible neuronal fates, thanks to @AmyYiChiaHuang1 for the invitation. Thrilled to meet folks in Boston. Food provided. 5:30 PM @ Warren Alpert 236
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Because the memory is so sparse, it's also cheap to override. Some neurons that ignore spatial patterning simply refuse to reactivate Vsx1, and the same type of neuron can be made from the Vsx domain and the Optix domain.
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By encoding patterning memory minimally, the brain region gets diversity where it's useful, and uniformity where it's necessary.
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Yen-Chung Chen 陳彥中 retweeted
This week at the CSHL Neurobiology of Drosophila conference🧬🪰 our Grad Student Raghu shares his work on stochasticity and determinism in the developing visual system! Plus don’t miss posters by Asif Bakshi (#77), Ben Choi (#101), and Sromana Mukherjee (#216) #CSHLdros
Conference week at CSHL on the Neurobiology of Drosophila. Come hear my talk on how a deterministic visual system is generated from stochastic processes. #cshldros
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Yen-Chung Chen 陳彥中 retweeted
Now preprinted at arxiv.org/abs/2509.07357
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Came for the boba, stayed for the content🧋
I'm psyched to share that my PhD paper is now out in @NeuroCellPress ! It's also my first paper as both first author and corresponding author, which means even more to me! 🥳 Thank my partner @ChiChiehLee_tw for her contribution to the most adorable ever graphic abstract 🥰
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Yen-Chung Chen 陳彥中 retweeted
Time to admit that despite extensive investment and effort we’ve largely failed as a field to understand how regulatory information is encoded in DNA and there isn’t clear progress on the horizon.
Most disease-associated GWAS signals fall in the non-coding genome🧬 Although assumed to influence expression, pinpointing the causal gene isn't easy. Two ways include: 1⃣eQTL mapping in relevant tissues/cells 2⃣in vitro CRISPRi screens This preprint compares the two👇
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Yen-Chung Chen 陳彥中 retweeted
🧵1/2 🚀 Breakthrough in #ALS research! @YaPingYen et al. in our lab uncovered a pivotal role of m6A in #ALS, and manipulating of m6A reservoir in motor neurons significantly slow down ALS onset and progression in SOD1 mouse model! rdcu.be/ekE3k
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Yen-Chung Chen 陳彥中 retweeted
Tomorrow, Weds 4/23/2025 (3-4:30pm ET):  @ClaudeDesplan (@NYU @NYU_CNS) will deliver the 2025 Joram Piatigorsky Basic Science Lecture & Award at @NIH in Masur Auditorium. @FNIH_Org @NatEyeInstitute   Details: bit.ly/4icO0pZ
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🎉
Incredibly proud of our undergrad researchers at #CURB2025! Congratulations to Hannah for winning Best Academic Poster and Sophia for Best Poster Aesthetic Design! Huge thank you to the department for organizing this opportunity to showcase undergraduate research excellence.
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Yen-Chung Chen 陳彥中 retweeted
🚨 Calling all early-career scientists! The #HFSP Fellowships call is now OPEN. 🚀 High-risk, high-reward #LifeScience projects 🌍 International mobility & #interdisciplinarity 💡 Deadline to initiate LOI: 7 May 2025 🔗 Apply now: zurl.co/Rob2W 🧪 #sts #Fellowships
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Yen-Chung Chen 陳彥中 retweeted
We are recruiting PIs at all levels @AcadSinica @IMBSinica, with guaranteed life-term stable intramural grant support until you retire! We dont need to make anything great again, as we have been always GREAT! nature.com/articles/d41586-0…
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Yen-Chung Chen 陳彥中 retweeted
Commentary on transcriptomes and cell types, by myself and @DesplanLab rdcu.be/d9BL6
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Yen-Chung Chen 陳彥中 retweeted
Another @DesplanLab & alumni reunion and at #DROS25
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It was a great pleasure to speak at the Single-cell Research Workshop organized by @PerrimonLab and @HongjieLi5 at #DROS25. It’s exciting to see all the rapidly evolving work diving deep into the diverse aspects of biological processes! (Photo credit: @YCDavidChen)
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