@zechnerlab

Theory lab at SISSA / Trieste. Interested in stochastic processes in biology & biophysics. @zechnerlab.bsky.social

 Dresden, Germany
zechnerlab.com
Joined March 2017
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  • Followers1K
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Exciting news! As of today, our group is part of SISSA in Trieste. Big THANK YOU to all current and past group members, collaborators and mentors and to @mpicbg for hosting us for 8 amazing years! If you are interested in joining us in Trieste, please get in touch! @Sissaschool
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Very happy to share the first article from my postdoc work in the Tomancak lab! biorxiv.org/content/10.1101/…. We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)
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Tommaso's paper on approximating moments of stochastic multiscale models is now out in Math Biosci! Fantastic job by @churli ! @csbdresden @mpicbg sciencedirect.com/science/ar…
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The new method is integrated into our symbolic moment generator Compartor, which is available on GitHub: github.com/zechnerlab/compar…

GitHub - zechnerlab/Compartor

Contribute to zechnerlab/Compartor development by creating an account on GitHub.

github.com
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Code for the numerical examples shown in the paper is also available: github.com/zechnerlab/lpac/

GitHub - zechnerlab/LPAC

Contribute to zechnerlab/LPAC development by creating an account on GitHub.

github.com
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This is now up @BiophysJ! Getting lipid signaling kinetic parameters from single-cell data with @MLennartz1 @PavelBarahtjan @looneycoons11 @JManuel9112 @zechnerlab @nadlerlab @MMSchuhmacher 😀😊 Read here! doi.org/10.1016/j.bpj.2023.1…
André Nadler@nadlerlab31 Jan 2023
Together with the @zechnerlab we have pushed live-cell quantitative lipid biochemistry to the single cell level. It works - but some lipids are weird. 🤓 Great effort by shared 1st authors @davidtgonzales1 and @MMSchuhmacher. Let us know what you think! biorxiv.org/content/10.1101/…

Quantifying single cell lipid signaling kinetics after photo-stimulation

Studying the role of molecularly distinct lipid species in cell signaling remains challenging due to a scarcity of methods for performing quantitative lipid biochemistry in living cells. We have...

biorxiv.org
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Cover image @ChemSystemsChem featuring our synthetic cell communities doi.org/10.1002/syst.2023000… 😀 @DoraTang5 @zechnerlab @mpicbg
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Zechner lab retweeted
TLecuitLab@LecuitLab19 Oct 2023
Two great talks from Tarun Mascarenhas and Anne-Lena Moor from Zechner lab on information transfer during ⁦@centuri_ls⁩ conference in Cargese. Very interesting. 😊
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Zechner lab retweeted
Dora Tang@DoraTang516 Aug 2023
Its out! We integrate Cell‐Free Quorum Sensing Gene Circuits into Droplet Interface Bilayers. A great platform for bio-inspired bidirectional communication. Beautiful work @gonzalesdavid in collaboration with @zechnerlab! See it here.... chemistry-europe.onlinelibra…

Bidirectional Communication between Droplet Interface Bilayers Driven by Cell‐Free Quorum Sensing...

Building communicating synthetic cells using droplet interface bilayers encapsulating cell-free expression systems with quorum sensing gene circuits.

chemistry-europe.onlinelibrary.wiley.com
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Zechner lab retweeted
NordenLab@NordenLab17 Jul 2023
Officially out now @EMBOPress with a beautiful cover by @NerliElisa! Enjoy...embopress.org/doi/full/10.15…
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How do distant DNA loci come into contact to activate genes? Our paper combining live imaging 🔬& polymer physics 🧬 to answer this is out in @ScienceMagazine! We show how chromosome packing & diffusion determine pairwise dynamics & transcription 👉science.org/doi/10.1126/scie… 1/n
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Very proud to share that former group member @LorenzoDuso was awarded the Otto-Hahn Medal for his outstanding PhD thesis @csbdresden @mpicbg Many congratulations for this exceptional achievement! Image: © David Ausserhofer / Max-Planck-Gesellschaft
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Congrats David!!
David T. Gonzales@davidtgonzales16 Mar 2023
Our preprint on building a bottom-up synthetic multicellular community is up! 😄 biorxiv.org/content/10.1101/… See how we use cell-free expression of quorum sensing gene circuits in DIBs to make synthetic cells that communicate and have feedback loops! @DoraTang5 @zechnerlab @mpicbg
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Together with the @zechnerlab we have pushed live-cell quantitative lipid biochemistry to the single cell level. It works - but some lipids are weird. 🤓 Great effort by shared 1st authors @davidtgonzales1 and @MMSchuhmacher. Let us know what you think! biorxiv.org/content/10.1101/…

Quantifying single cell lipid signaling kinetics after photo-stimulation

Studying the role of molecularly distinct lipid species in cell signaling remains challenging due to a scarcity of methods for performing quantitative lipid biochemistry in living cells. We have...

biorxiv.org
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Excited to share Anne's new paper in Phys Rev Res, presenting a method to quantify information transmission (-rates) in biochemical networks. Congrats!! @csbdresden @mpicbg journals.aps.org/prresearch/…

Dynamic information transfer in stochastic biochemical networks

We develop numerical and analytical approaches to calculate mutual information between complete paths of two molecular components embedded into a larger reaction network. In particular, we focus on a...

journals.aps.org
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Open PhD position to work with me on the Stochastic dynamics and thermodynamics of living systems @KCL_Physics @KingsCollegeLon to start in Oct ‘23 findaphd.com/phds/project/st…

Stochastic Dynamics and Thermodynamics of Living Systems. at King’s College London on FindAPhD.com

PhD Project - Stochastic Dynamics and Thermodynamics of Living Systems. at King’s College London, listed on FindAPhD.com

findaphd.com
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Thanks @Dmichiel1 @wendy_bickmore for highlighting in @MolecularCell cell.com/molecular-cell/full… our recent work science.org/doi/full/10.1126… visualizing a TAD-forming CTCF/cohesin loop in live cells and showing these structures to be dynamic, rare, and largely partially extruded.
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Next up @davidtgonzales1!! Wonderful example of a multidisciplinary PhD project, combining both experiment and theory. Many congratulations to your graduation David!! @tanglab @mpicbg @csbdresden @imprs_mpicbg
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Huge congratulations to @FOltsch for his outstanding PhD defense last week! Many thanks for all the great work & fun and best of luck for your future adventures! @imprs_mpicbg @csbdresden @mpicbg
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A thing to copy is @mpicbg tutorial with PhD students and ECRs before a seminar. I had a great time with these outstanding scientists. Many thanks to @zechnerlab for the invitation and discussions. Near-zero carbon footprint and no jetlag added bonus.
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