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Joined October 2020
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Agard Lab retweeted
Smriti Sangwan (@smriti_sangwan) from the @agardlab & Peter Walter labs @UCSF is about to present her research - molecular mechanisms of translational regulation.
🎉🎉🎉
New featured image on our homepage!
nature.com/ncomms/
Related to this article:
The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice
nature.com/articles/s41467-0…
@ENieweglowska @AgardLab @UCSF
#phagenucleus #jumbophage #phage #structuralbiology
ALT A lattice of protein tetramers
Congratulations to Maru & team on the lab’s latest pub!
PP5 requires the molecular chaperone Hsp90 to dephosphorylate CRaf kinase and Hsp90 cochaperone Cdc37. Here, authors show how Hsp90 acts as a platform to allow for targeted dephosphorylation by PP5.
nature.com/articles/s41467-0…
Check out the latest preprint from @andreafossati9 and @MozumdarDeepto on using SEC-MS to identify protein:protein interactions during jumbo phage infections! Congrats, team!
#phage #jumbophage #secms
New preprint alert!
Here we show how SEC-MS is a powerful tool for host pathogen interactions profiling. We applied it to Jumbophages, which are large bacterial viruses (>300 genes) holding great potential as antibiotics.
What did we find? 1\n
biorxiv.org/content/10.1101/…
Please check out our latest publication from grad student @ENieweglowska on the self-assembly of the phiPA3 phage nucleus! Congrats to the whole team! @MmendezMoran @minkbaek @UWproteindesign @yifan_ucsf @joeBondyDenomy
Excited to share the, now published, final version of my grad school research! Here are a few PhuN highlights from the full story. 🧵
#phage #jumbophage #cryoem
nature.com/articles/s41467-0…
Check out our latest preprint! #CryoEM structures of immunophilins, FKBP51 and FKBP52, in complex with Hsp90 and the glucocorticoid receptor, demonstrating the FKBP co-chaperones directly bind an Hsp90 client to regulate client activity. From recent grad @ChariMN w/ Jill Johnson
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the Glucocorticoid Receptor biorxiv.org/cgi/content/shor… #bioRxiv
Agard Lab retweeted
@AgardLab shared amazing data (published/unpublished) on Hsp90 chaperone complexes. @Hsp90Machine
High resolution cellular cryoET!
We optmized in situ cryoET to achieve 6 A reconstructions of mouse sperm doublets! The unique tertiary structures allow de novo protein identification of novel sperm proteins by computationally searching in the AlphaFold2 library of entire mouse proteome! biorxiv.org/content/10.1101/…
Agard Lab retweeted
A family of novel immune systems targets early infection of nucleus-forming jumbo phages biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Agard Lab retweeted
this just in --- our FTD CWOW website is LIVE! cwow.ucsf.edu/ Time to spread the news! Great work from our team @Karen_Shuster, @aimee_kao @YokoyamaLabUCSF @karchlab @AgardLab @metadsr_ @tauCWOW #ftdcwow
Agard Lab retweeted
We’re excited to announce that David Agard, Bridget Carragher + Clint Potter have joined our new @ChanZuckerberg Imaging Institute to bring together scientists and engineers to develop new cryoelectron microscopy imaging hardware and software
🧵czi.co/ImagingInstitute
Congratulations, @MmendezMoran! #phdcandidate
I’ve passed my qualifying exam—a huge milestone on my way to a PhD!
So lucky to have amazing mentors and lab mates doing incredible science and throwing even more incredible @AgardLab parties!
Check out our latest pre-print from postdoc Zhen Chen @ZhenChentccz on mammalian sperm axonemes revealed by in situ cryoET!
Our preprint on asymmetric axonemes of mammalian sperm revealed by FIB-SEM/cryoET: biorxiv.org/content/10.1101/…
Thanks for the support from the Vale lab and Agard lab! This work would not be possible without my amazing collaborators from the Lishko lab and Janelia Research Campus.
Agard Lab retweeted
Explore emerging research and network with peers at our Protein Folding in the Cell Conference. Organized by Manajit Hayer-Hartl @MPI_Biochem and Jeffery Kelly @scrippsresearch. Don't miss keynote speaker David A. Agard @AgardLab bit.ly/3NGsdc3 #PFCSRC22
Agard Lab retweeted
The {varphi}PA3 Phage Nucleus is Enclosed by a Self-Assembling, 2D Crystalline Lattice biorxiv.org/cgi/content/shor… #bioRxiv
Check out our latest preprint showing that the major protein enclosing the Phage Nucleus (PhuN) forms a tetrameric lattice with C2 symmetry. The symmetry establishes 4 unique interfaces, two large enough to act as channels for small molecules, RNA, or even unfolded proteins.
Excited to share our findings about the self-assembly of the phage nucleus! In short: it’s primarily composed of a single ~70 kDa protein and forms a beautiful (I may be a little biased 😍) C2 symmetric lattice!
biorxiv.org/content/10.1101/…
Congratulations to all of our authors! @ENieweglowska, Axel Brilot, @MmendezMoran, @minkbaek, Junrui Li, Claire Kokontis, David Baker (@UWproteindesign), @yifan_ucsf, and @joeBondyDenomy
Agard Lab retweeted
We've got that Friday feeling! Earlier this week, #tau2022 was a success! Our #ftdcwow team was in attendance and thrilled to discuss about Tau. @karchlab @YokoyamaLabUCSF @AimeeKaoLab @AgardLab @metadsr_ alz.org/tau/overview.asp
Agard Lab retweeted
#CryoeM #CryoET has enormous potential allow researchers to study #structuralbiology in situ but low throughput limits applications. This new publication from Shawn Zheng of @AgardLab @UCSF addresses that problem and offers on-the-fly processing!
biorxiv.org/content/10.1101/…