Our lab develops quantitative methods to design therapies for tuberculosis and to understand complex cell behaviors.
Tufts University, Boston, MA
Joined November 2013
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Bree Aldridge retweeted
.@trevercsmith of @TuftsMedSchool has been named winner of the #BAL 2024 Emerging Leader Award. Dr. Smith will receive $150K for his pioneering research on combination therapies for persistent #Lymedisease. His work aims to create a first-of-its-kind drug interaction compendium to better target persistent Borrelia burgdorferi (Bb) infections. This could lead to more effective treatments, offering new hope for those w/ persistent #Lyme.
Read the full release here: bit.ly/4d3Slu1
#Lymediseaseresearch #Lymetherapeutics
Bree Aldridge retweeted
Happy to celebrate the inauguration of new Tufts President Sunil Kumar and share the platform with TUSM Dean @hboucher3 GSBS Professor @AldridgeLab Tufts A&S Graduate Dean Barbara Brizuela @TuftsUniversity @TuftsMedicalCtr @TuftsMedSchool @TuftsGSBS
Bree Aldridge retweeted
(Please RT)
You like:
- bacteria ?
- ☀️& 🩴?
- adventurous & cool tweeps?
then --> Goa (India) for BMSV23, #EMBObacMorph23,
meetings.embo.org/event/23-b…, 6-10 Geb, 2023 by @sunishk @dnarepairlab , submit abstracts asap
Bree Aldridge retweeted
When @RengarajanLab speaks with students pursuing careers in #STEM, she advises them to “stay as bold and ambitious as possible." Read more about her guidance for early-career scientists and her microbiology journey: asm.social/yE
Bree Aldridge retweeted
Tn seq libraries of M.tb in diverse mouse backgrounds
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Bree Aldridge retweeted
Very happy to advertise my new introductory book on disordered systems, stochastic processes and their applications. I am grateful to the Harvard students who took my course for their feedback over the last 7 years, as I developed the materials.
amir.seas.harvard.edu/thinki…
Bree Aldridge retweeted
Looking to pursue a PhD or MD/PhD in #biomedical sciences? The NIH-funded @TuftsUniversity PREP provides significant research experience and skills to prepare recent college graduates from underrepresented groups for success. Apply by March 1, 2022
gsbs.tufts.edu/academics/PRE…
Bree Aldridge retweeted
(1/9) Excited to share our preprint on the use of deep learning to accurately predict antibiotic resistance TB from genomic data AND generate hypotheses about specific positions in the genome causing resistance. @AndrewLBeam @MahaFarhat @changHyoon biorxiv.org/content/10.1101/…
Bree Aldridge retweeted
biorxiv.org/content/10.1101/… beautiful paper by Shumin Tan’s lab revealing heterogeneity in Mtb lesion environments. They reveal spatial segregation of actively replicating Mtb and how this affects susceptibility to drug treatment.
Bree Aldridge retweeted
Excited! Final version out now alongside complementary work from @mbogyo @BrettMBabin, both showing the ins and outs of ABPP for Mtb inhibitor discovery. @hirenpMD @armandcognetta @trevercsmith @JefCavalier @canaanlab @AldridgeLab
sciencedirect.com/science/ar…
Shout-out to co-first Mike Li, Hiren Patel and @armandcognetta @trevercsmith @JefCavalier Ivy Mallick for bringing this story to fruition with library screening, ABPP, enzymology, docking, and MorphEUS morphological analysis 2/n biorxiv.org/content/10.1101/…
Bree Aldridge retweeted
The Tuberculosis Drug Accelerator, an experiment designed to facilitate collaboration in drug discovery, has reached a 10-year landmark.
Carl Nathan @WeillCornell and colleagues review the consortium’s achievements, advantages and limitations. #TB
nature.com/articles/s41591-0…
Bree Aldridge retweeted
1/ Fantastic #AcinetoVibes product of hard work by @MarioFeldman9. Great job by @m_strent. Thanks to all involved. Here is some more background on presentation by @JHernBird.
biorxiv.org/content/10.1101/…
Bree Aldridge retweeted
Now we know that a 4 months TB treatment regimen works 🙌
4-month rifapentine-based regimen containing moxifloxacin may allow for a shorter course in patients with drug-susceptible pulmonary #tuberculosis, new study reveals. Read here: nejm.org/doi/full/10.1056/NE… @NEJM
Bree Aldridge retweeted
"It took them how many decades to recognize that one of the most regenerative tissues is found inside the uterus?” one expert notes. The reason, she believes, is simple: "Because none of the researchers had uteruses." nyti.ms/3vrEoQ6
Bree Aldridge retweeted
Excited to share our first preprint on inhibitors of M. tuberculosis that we characterized using a competitive activity-based protein profiling platform. A long-haul team effort from @jcslab @AldridgeLab @canaanlab and the Cravatt lab. 1/n
Bree Aldridge retweeted
Every minute, 3 people die from TB, a disease we can prevent & cure. But many are fighting for change. On #WorldTBDay we honor the heroes working to #EndTB. @TBAlliance @gatesfoundation @StopTB There's no time to waste when saving lives. #TheClockIsTicking
Bree Aldridge retweeted
Remember when the genus #Mycobacterium got split into 5 genera and everyone said 'seriously?'? Of course you do!
Well new pre-print from myself and collabs shows you can forget all that, the genetic signatures support a single genus.
You can all rest easy
biorxiv.org/content/10.1101/…
Bree Aldridge retweeted
As we reflect on another #BlackHistoryMonth, I want to take a moment to talk about Black Futures, specifically in a realm that I am most familiar with, academia and STEM.
Bree Aldridge retweeted
the rate at which Black scientists are awarded @NIH grants is ~55% of that of non-Black investigators with the same qualifications.
a call to end funding discrimination against Black scientists published in @CellCellPress today:
cell.com/cell/fulltext/S0092…
#FundBlackScientists