Stem Cell Metabolism lab. Using iPSCs to search for cures for rare mitochondrial diseases. Editor-in-Chief of Stem Cell Research. @AlePrigio@fediscience.org
Düsseldorf, Germany
Joined December 2016
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Alessandro Prigione retweeted
The Impact of Mutant #Huntingtin on Neurodevelopment Unveiled through Human #Brain #Organoid Models. #BrainOrganoid
By Pawel Lisowski，Selene Lickfett，@AlePrigio，et al.
More Brain Organoids Research Highlights: isoor.org/brain-neural-organ…
Article Link: nature.com/articles/s41467-0…
Alessandro Prigione retweeted
Next up in the modelling IEM session, Dr @AlePrigio discusses developing brain organoid models for the study of #mitodisease. In addition to developing robust models, he has begun working on drug repurposing
#excitingstuff #raredisease #SSIEM2024
(not brains in jars)
Beautiful run this morning for the Kastelo charity run. Thanks to the SSIEM2024 organizers! @ssiem2024_Porto
Alessandro Prigione retweeted
Researchers at @MDC_Berlin and @HHU_de have identified a gene that affects mitochondria in an #organoid model of #Huntington’s disease. The gene may contribute to brain abnormalities much earlier than previously thought. @NatureComms @metzgerlab @AlePrigio
mdc-berlin.de/news/news/new-…
It's out! Excited to share our latest work in Nat Comms.
We found that mutant Huntingtin impairs human neurodevelopment in brain organoid models through early disregulation of the mitochondrial protein CHCHD2.
Thanks to all coauthors!
nature.com/articles/s41467-0…
This was quite a long project starting several years ago and a huge collaborative efforts! Mainly with @HHU_de and @MDC_Berlin but also other labs in Germany, Greece and Spain!
Great collaboration with co-last author @metzgerlab. And thanks to funding from @dfg_public
Delighted to share our latest preprint! We used iPSC-derived brain organoids and deep learning screenings to identify new drugs to treat the mitochondrial disease Leigh syndrome.
Graduate student Carmen Menacho received a Merit Award for this #ISSCR2024.
biorxiv.org/content/10.1101/…
Great collaboration with Antonio del Sol, @OlePless, Christine Rose, @eperlste and many others. Grateful to the support from @BMBF_Bund and @EJPRareDiseases, European Commission, @cure_mito, @UMDF, PALS, and Mito Help!
Alessandro Prigione retweeted
How do axons maintain functional #mitochondria? Happy to share our last #CLUH story. #ScienceAdvancesResearch science.org/doi/10.1126/scia…
Alessandro Prigione retweeted
Postdoc positions in pancreas development & stem cells in the Spagnoli Lab @LabSpagnoli
Come join us as a #postdoc to lead a new exciting #T1D Grand Challenge-funded research program on engineering #stem cell-derived islets
jobrxiv.org/job/kings-colleg…
#d...
jobrxiv.org/job/kings-colleg…
Wonderful opportunity! A great lab in a new exciting institute in a great city. Apply!
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Alessandro Prigione retweeted
Very happy to share our new article of the interaction of mitochondria, innate immunity and viral infections and the relevance for brain &liver disease. Impressive work by @KangYilin. Thanks @hepojoki @Olli_Vapalahti and all collabs! @helsinkiuni @ASW_lab rdcu.be/dDx2G
Alessandro Prigione retweeted
'Balancing neuronal activity to fight neurodevelopmental disorders'
'Spotlight' commentary by Stephanie Le, Carmen Menacho & Alessandro Prigione @AlePrigio
cell.com/trends/neuroscience…
discussing Rylaarsdam et al., @NatureComms, @GuemezGamboaLab
nature.com/articles/s41467-0…
Delighted to share our spotlight article @TrendsNeuro to comment on a beautiful work by the Guemez-Gamboa lab on modeling a rare neurodevelopment disorder with brain organoids. authors.elsevier.com/sd/arti…
Link to original article. nature.com/articles/s41467-0…
Alessandro Prigione retweeted
📣REGISTRATION is open
Please follow the link sfb1218.uni-koeln.de/mito-cr… #mito #crc1218 @MPIAGE @CECAD_ – at Cologne, Germany
📣 SAVE THE DATE 📣 Join us at the #MITOchats Symposium on June 4th, 2024, at Max Planck Institute for Biology of Ageing, Cologne ✨ Featuring global experts, cutting-edge research, and free participation! Registration opens March 2024! Stay tuned here & on our website #mito
Must-read review article
Nature review article: A break in mitochondrial endosymbiosis as a basis for inflammatory diseases go.nature.com/3OAPC0C
Alessandro Prigione retweeted
Why Drug Developers Have a Growing Interest in Targeting Mitochondria podbean.com/ew/pb-7qnmn-154f…
Listen and learn...
Alessandro Prigione retweeted
🧠The synapse density rapidly increases post-birth👶, reaches its maximum during infancy, at which stage it is double the amount that will be observed in adulthood.
📕Conel, JL. The postnatal development of the human cerebral cortex. Cambridge, MA: Harvard University Press; 1975
