Alex Keeble retweeted
Researchers find increased senescent #macrophage burden in muscle & #knee in preclinical #ACL injury model, and provide evidence that treatment with #senolytics is an effective strategy to mitigate posttraumatic #osteoarthritis severity. ow.ly/VpoN50ZzPlR
Alex Keeble retweeted
Neuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition
jci.org/articles/view/190646
Alex Keeble retweeted
Congrats to @UKYCMB on this absolute banger! “Exercise-associated microbial metabolites prevent skeletal muscle atrophy in adult female mice” #myotwitter
nature.com/articles/s41467-0…
Excited to share a new publication from the @ChrisFryPhD and @Allison_M_Owen labs! We identify senescent macrophages as contributors to quadriceps atrophy and PTOA following ligament injury. Proud to have contributed to this work with an amazing team.
pubmed.ncbi.nlm.nih.gov/4234…
Alex Keeble retweeted
The skeletal muscle slow myosin heavy chain regulates mammalian metabolic homeostasis through the NRF2 pathway
science.org/doi/10.1126/scia…
Alex Keeble retweeted
No less, enabling the design de novo proteins, a brilliant review @nature
"Over the next five to ten years, we anticipate the design of sophisticated protein nanomachines and materials with functionality ranging far beyond that generated during natural evolution for a wide range of
applications in medicine, technology and sustainability,"
nature.com/articles/s41586-0…
Alex Keeble retweeted
Back-to-back papers from @AlexKeeble5 and @saragonzalezve . Working with @MVFranchi , we show that limb suspension and post-ACLR muscle exhibit fundamentally different muscle transcriptomic signatures.
journals.physiology.org/doi/…
Alex Keeble retweeted
Excited to share our findings on sex differences in muscle signaling after ACL reconstruction—females exhibit a markedly divergent transcriptomic response, with greater susceptibility to atrophy, oxidative stress, and impaired angiogenic signaling:
link.springer.com/article/10…
Alex Keeble retweeted
Treating age-related loss of muscle mass and function: Where should we be focusing?
physoc.onlinelibrary.wiley.c…
Alex Keeble retweeted
We wrote this letter to address the overly rigid preregistration requirements imposed now by many journals on exploratory experimental physiology research - time to align guidelines with contemporary research methods!
@proferikrichter
@ISMCopenhagen
physoc.onlinelibrary.wiley.c…
Alex Keeble retweeted
1/ Why do muscles atrophy with aging and disuse?
Is it because each tiny little myofibril gets smaller… or is it because we lose myofibrils?
In our new study, we addressed this in humans and mice. biorxiv.org/cgi/content/shor…
Full breakdown of the findings in this thread 👇
Alex Keeble retweeted
In 1990, as Voyager 1 was leaving the solar system, Sagan fought a long internal battle at NASA to turn the cameras around one last time to photograph Earth. Many engineers opposed it, fearing it might damage the cameras or waste time.
But Sagan’s successful effort resulted in the "Pale Blue Dot" image. He used this tiny, 0.12-pixel speck of Earth to write his famous reflection on how "every human being who ever was" lived on that "mote of dust suspended in a sunbeam".
Alex Keeble retweeted
Congrats to @AlexKeeble5 for his manuscript being selected as Editor’s Choice and making the cover at @JPhysiol for December! doi.org/10.1113/JP286815
Very excited to share some of our recent work studying primary human MPCs from patients with late stage CKD! We identify metallothionein-induced zinc deficiency as a contributor to attenuated myogenesis in this population.
@ChrisFryPhD @saragonzalezve
journals.physiology.org/doi/…
Alex Keeble retweeted
Upcoming Postdoc Position! With Chris Nelson’s lab at U of A, we are looking for a fully supported 2-year postdoc to work on muscle gene editing and detection of gene doping in vivo. If interested, email myself and Chris: [email protected] and [email protected] #myotwitter
Alex Keeble retweeted
A heavy lift from a literal strongman, PhD candidate @PJKoopmans “The Age-Dependent Resident Myonuclear Multi-Omic Response to a Skeletal Muscle Hypertrophic Stimulus” 💪🏻 biorxiv.org/content/10.1101/…
Alex Keeble retweeted
BIG congrats to @saragonzalezve for passing her quals today - welcome to PhD candidacy! A much deserved celebration @UKYCMB
Alex Keeble retweeted
9/ Shoutout to co-first authors @jhibbert_phd and @kentjorgenson_ and the rest of the team pushing this 8-year-long project to the finish line. The next step is to get it published. Please give it a repost if you think it will be impactful for the field. biorxiv.org/content/10.1101/…

















