Physiologist

Joined September 2022
Alex Keeble retweeted
Researchers find increased senescent #macrophage burden in muscle & #knee in preclinical #ACL injury model, and provide evidence that treatment with #senolytics is an effective strategy to mitigate posttraumatic #osteoarthritis severity. ow.ly/VpoN50ZzPlR
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Neuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition jci.org/articles/view/190646
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Alex Keeble retweeted
Big progress vs cancer, folks. The kind of event curves from randomized trials that we've not seen before for a couple of the most deadly cancers. Congrats to the oncology research community for getting these trial done. #ASCO26, @ASCO
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Alex Keeble retweeted
LEBRON DELIVERED IN THE SERIES-CLINCHING WIN! 👑 28 PTS 👑 7 REB 👑 8 AST Lakers will face the Thunder in Round 2 of the NBA Playoffs presented by @Google 🍿
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Alex Keeble retweeted
No less, enabling the design de novo proteins, a brilliant review @nature "Over the next five to ten years, we anticipate the design of sophisticated protein nanomachines and materials with functionality ranging far beyond that generated during natural evolution for a wide range of applications in medicine, technology and sustainability," nature.com/articles/s41586-0…
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Alex Keeble retweeted
Back-to-back papers from @AlexKeeble5 and @saragonzalezve . Working with @MVFranchi , we show that limb suspension and post-ACLR muscle exhibit fundamentally different muscle transcriptomic signatures. journals.physiology.org/doi/…
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Alex Keeble retweeted
Excited to share our findings on sex differences in muscle signaling after ACL reconstruction—females exhibit a markedly divergent transcriptomic response, with greater susceptibility to atrophy, oxidative stress, and impaired angiogenic signaling: link.springer.com/article/10…
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We wrote this letter to address the overly rigid preregistration requirements imposed now by many journals on exploratory experimental physiology research - time to align guidelines with contemporary research methods! @proferikrichter @ISMCopenhagen physoc.onlinelibrary.wiley.c…
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1/ Why do muscles atrophy with aging and disuse? Is it because each tiny little myofibril gets smaller… or is it because we lose myofibrils? In our new study, we addressed this in humans and mice. biorxiv.org/cgi/content/shor… Full breakdown of the findings in this thread 👇
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In 1990, as Voyager 1 was leaving the solar system, Sagan fought a long internal battle at NASA to turn the cameras around one last time to photograph Earth. Many engineers opposed it, fearing it might damage the cameras or waste time. But Sagan’s successful effort resulted in the "Pale Blue Dot" image. He used this tiny, 0.12-pixel speck of Earth to write his famous reflection on how "every human being who ever was" lived on that "mote of dust suspended in a sunbeam".
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Congrats to @AlexKeeble5 for his manuscript being selected as Editor’s Choice and making the cover at @JPhysiol for December! doi.org/10.1113/JP286815
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Upcoming Postdoc Position! With Chris Nelson’s lab at U of A, we are looking for a fully supported 2-year postdoc to work on muscle gene editing and detection of gene doping in vivo. If interested, email myself and Chris: [email protected] and [email protected] #myotwitter
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BIG congrats to @saragonzalezve for passing her quals today - welcome to PhD candidacy! A much deserved celebration @UKYCMB
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