😃 M.D. 😄 Gastroenterology and Hepatology, Prince of Songkla University, Thailand 🌟#liverx 📣https://xitter.cf/t.co/7C1acHkfAo

Thailand
Joined June 2014
First day in #APASL2024: mission ✔️ Thank you, Professor Sombat @battan5410 and Professor @WRayKimMD, for the insightful comments🙏🏼 in @AASLDtweets @APASLnews research workshop
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We are pleased to report that APASL-STC 2026 was successfully held at the Grand Hyatt Singapore from 9 to 12 July 2026 You may click HERE to view the Video Highlights of the Conference. ddec1-0-en-ctp.trendmicro.co…
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𝘏. 𝘱𝘺𝘭𝘰𝘳𝘪 infection is an infectious disease, and treatment regimens should ideally be guided by antimicrobial-susceptibility testing whenever possible. 🔗 nej.md/4Bj3O58 Both phenotypic (culture-based) and molecular methods of antimicrobial-susceptibility testing are available (seen in figure). Culture-based testing remains the reference standard because it is the only method that can ascertain the susceptibility of isolates to all antibiotics commonly used for eradication. Molecular antimicrobial-susceptibility testing offers greater efficiency than culture-based testing by eliminating the need for 𝘏. 𝘱𝘺𝘭𝘰𝘳𝘪 culture. Molecular-based testing can be conducted with fresh or formalin-fixed gastric-tissue samples (used for histopathological examination) and successfully cultured isolates. More recently, gastric-fluid samples obtained from a swallowed gastric string have emerged as a cost-effective alternative culture-based testing method. Stool-based molecular antimicrobial-susceptibility testing is now available, which avoids invasive endoscopy. Commercial polymerase-chain-reaction–based kits are now available for identifying 𝘏. 𝘱𝘺𝘭𝘰𝘳𝘪 resistance to clarithromycin and levofloxacin by detecting specific mutations in the 𝘏. 𝘱𝘺𝘭𝘰𝘳𝘪 23S ribosomal RNA and gyrA genes, respectively. A meta-analysis reported high accuracy of these molecular methods for detecting antibiotic resistance in gastric-biopsy samples, with sensitivity and specificity of 96% and 96%, respectively, for clarithromycin resistance and 97% and 99% for quinolone resistance. Learn more in the Review Article “𝘏𝘦𝘭𝘪𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳 𝘱𝘺𝘭𝘰𝘳𝘪 Infection — Advances, Challenges, and the Road Ahead” by Hong Li, MD, PhD, Francis Megraud, MD, and Barry J. Marshall, MD: nej.md/4Bj3O58
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Original Article: Retatrutide Once Weekly for Treatment of Obstructive Sleep Apnea (phase 3 TRIUMPH-1-OSA and TRIUMPH-2-OSA trials) nej.md/4BmAHOI #SleepEurope2026 | @ESRS_Sleep
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📑 Seladelpar in patients with #PBC and compensated #cirrhosis: Efficacy and safety from RESPONSE and ASSURE studies‼️ #OpenAccess #LiverX journals.lww.com/hepcomm/ful…
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The discovery of 𝘏. 𝘱𝘺𝘭𝘰𝘳𝘪 has advanced the prevention and treatment of gastritis, peptic ulcers, and gastric cancer. Progress has been made in the research of 𝘏. 𝘱𝘺𝘭𝘰𝘳𝘪 infection. These advances are discussed in a new review. Read the Review Article “𝘏𝘦𝘭𝘪𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳 𝘱𝘺𝘭𝘰𝘳𝘪 Infection — Advances, Challenges, and the Road Ahead” by Hong Li, MD, PhD, Francis Megraud, MD, and Barry J. Marshall, MD: nej.md/4Bj3O58
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💡#GUIDANCE009: Is #adjuvant PD-1 blockade needed after #conversion #hepatectomy for initially unresectable #HCC? #LiverCancer @ResearchKarger 👉 114 pts received adjuvant PD-1 inhibitors and 311 stayed drug-free after conversion hepatectomy. 👉 No significant difference between groups in TFS (HR 0.85, 95%CI 0.63-1.15) or OS (HR 0.66, 95%CI 0.44-1.00). 👉 Adjuvant therapy still showed no significant TFS or OS benefit after propensity score matching, in a 12-month landmark analysis, or among pts with pathological CR. DOI: doi.org/10.1159/lic/admag021 @ILCAnews @EASLnews @myESMO #LiverX
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📑 Low serum pseudocholinesterase levels are associated with mortality in patients with #HCC‼️ #OpenAccess #LiverX journals.lww.com/hepcomm/ful…
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🚨 New phase II pilot study (FAB-HCC) explores fecal microbiota transplantation to overcome #immunotherapy resistance in #HCC @NatureComms 👏 Congrats to @PinterMatthias & team on this impressive work! 👉 N = 12 advanced HCC pts with progression on prior Ate/Bev; treated with fecal microbiota transplantation (#FMT) + Ate/Bev rechallenge 👉 Safety: Gr 3–4 TRAEs in 41.7%; no serious TRAEs or treatment-related deaths 👉 ORR 33.3%, DCR 83.3%, median PFS 6.9 mo (mRECIST); median OS 15.5 mo 👉 FMT shifted gut microbiota toward donor profiles, with enrichment of response-associated bacteria DOI: doi.org/10.1038/s41467-026-7… @ILCAnews @myESMO @EASLnews #GutMicrobiome
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Anouk Overdevest presents data from the COBRA trial, comparing 1 day of antibiotic treatment with 4-7 days in patients with acute cholangitis after adequate biliary drainage #UEGWeek @my_ueg #GITwitter #IDTwitter
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#liverTwitter Proud to see the CORE database we built already generating meaningful insights. Our latest study uses CORE (23 centres now) to model the natural hx of decompensation, an exciting first step toward answering important clinical questions. journals.lww.com/hepcomm/ful…
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#LiverTwitter Happy to share our latest paper from the #CORE consortium, an Asia Pacific led initiative to understand compensated liver cirrhosis. Our latest paper explore how statin reduces the risk of hepatic decompensation and LRE @hepinternation1. link.springer.com/article/10…
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#Baveno VIII consensus in portal hypertension #CSPH Full Consensus Report now @JHepatology @EASLnews journal-of-hepatology.eu/art…
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💡 Complete pathologic response (cPR) is linked to better survival after #LT for #HCC @AnnalsofSurgery 👉 Imaging-pathology concordance was poor (30.5%), with imaging overestimating response in 42.6%. 👉 cPR higher with Y-90 (41.2%) and ablation (36.4%) vs TACE (24.0%). 👉 cPR vs no cPR: 5-yr OS 86.6% vs 77.4%, RFS 76.9% vs 63.1%. DOI: doi.org/10.1097/SLA.00000000… @AASLDtweets @ASCO @AACR #LiverX #UNOS
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🔥 New in @JHepatology! @StephenLChan1 @LorenzaRimassa Primary results from the Phase IIIb #SIERRA study—evaluating first-line #STRIDE (durvalumab + tremelimumab) in poor-prognosis unresectable #HCC (Child-Pugh B7/B8, ECOG PS 2, or Vp4; N=111) 👉 Grade 3/4 PRAEs (≤6 mo): 19.8% 👉 ORR: 14.4% 👉 Median OS: 10.6 mo 🧐 Demonstrates a favorable risk-benefit profile and manageable safety for STRIDE in historically underrepresented, high-unmet-need uHCC populations. #LiverX @ILCAnews @EASLnews @myESMO @ASCO
First-line durvalumab and tremelimumab in poor-prognosis unresectable HCC: Phase IIIb single-arm SIERRA study @JHepatology doi.org/10.1016/j.jhep.2026.… 👉ORR: 14.4% 👉CP B7/B8: 6.8% 👉ECOG PS 2: 21.3% 👉Vp4: 15.0% 🧐overall favourable risk-benefit profile for STRIDE @myESMO @EASLnews @ILCAnews
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🚨 New multicenter real-world comparison of ATZ/BEV vs DUR/TRE in unresectable #HCC with #PVTT #LiverCancer @ResearchKarger 👉 N = 1,201 Child-Pugh A pts: ATZ/BEV (n=1,015) vs DUR/TRE (n=186) 👉 Overall cohort: ORR 31.0% vs. 31.7% (p=0.86), DCR 78.4% vs. 62.4% (p<0.01); median PFS 6.9 vs. 5.3 mo (p=0.049), median OS 24.9 vs. 31.0 mo (p=0.72) 👉 Vp4 subgroup (n=55): median OS 16.6 vs 6.1 mo (HR 3.60, P<0.01) favoring ATZ/BEV 👉 OS difference attenuated in 8-wk landmark analysis (P=0.068), so this is hypothesis-generating and needs validation DOI: doi.org/10.1159/lic/admag015 @ILCAnews @myESMO @EASLnews @AACR @ASCO #Atezolizumab #Bevacizumab #STRIDE
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❓ Does #TIPS (a shunt that lowers portal pressure) fuel #HCC growth in fatty liver? New study in Liver Cancer @ResearchKarger 👇 👉 Normal-diet mice: shunt had no effect on HCC growth 👉 High-fat-diet (#MASLD) mice: shunted tumors grew faster (1.14 vs 0.22 mm³/week, p<0.001) 👉 MASH patients (US transplant registry): faster tumor growth with TIPS (p=0.003) The effect depends on the liver's metabolic context. Needs further validation. DOI: doi.org/10.1159/lic/admag017 @ILCAnews @myESMO @EASLnews #LiverX
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In the phase 3 INDIGO trial, obexelimab led to a lower risk of disease flares than placebo among patients with IgG4-related disease. Glucocorticoid use was lower and the incidence of remission was higher with obexelimab than with placebo. Full trial results and Research Summary: nej.md/4fKYQG4
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New online! Building the next generation of gastroenterology and hepatology research leaders in Asia: from disease burden to scientific leadership dlvr.it/TVhmKV
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Use Fibroscan liver stiffness + platelet count to document: ➡Clinically Significant Portal Hypertension (CSPH) ➡compensated Advanced Chronic Liver Disease (cACLD) Our Hepatology📰 shows the categories & rationale & argues for category of "critical" CSPH journals.lww.com/hep/fulltex…
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🆕🔥🟢Just published by @ebtapper et Al ACG Clinical Guideline: Preventive Care for Patients With Cirrhosis #idxposts journals.lww.com/ajg/fulltex…
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