#AvH postdoc in @SimmelLab @robotic_DNA | I am passionate about synthetic biomachines and DNA origami nanorobots 𧬠π€| @McGillU @UZH_en alumnus | ππ³βπ
Munich, Bavaria
Joined February 2019
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Can one self-assemble containers the size of cells using a single DNA origami? Well, now we can.
Check out our preprint, where we present the underlying Dipid (DNA origami inspired by lipids) framework(biorxiv.org/content/10.1101/β¦).
(TEM image of a collapsed container)
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Check out our new DNA-templated approach to protein mimicry! We assemble mini-proteins from peptides using DNA scaffolds, bypassing peptide folding constraints. This opens a new sequence space for protein design! Proud of F. Zhao and M. Frandsen! @J_A_C_S pubs.acs.org/doi/full/10.102β¦
Fluorescent base rotors are typically sensitive to dynamics of the opposing nucleobase; but can they be sensitive enough to detect distant #DNA base lesions? Check out our paper using tsT & tsC to probe O6-methylguanine damage and #enzymatic_repair.
pubs.rsc.org/en/Content/Artiβ¦
This work was the result of a great teamwork between Luedtke lab @WilliamCopp16 @McGillChemistry @McGillScience and @alba_guarne & Tianxiao (Peter) Yang @CRBSMcGill @McGillBiochem.
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How to "beer garden" like a pro! @SimmelLab @robotic_dna in action!
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It is still possible to apply for a PhD position with us until June 30. The @JuricekLab is ready to grow :)
Apply here: jobs.uzh.ch/offene-stellen/pβ¦
RT appreciated π
@UZH_Chemistry @UZH_en @UZH_ch
#PhDChat #PhDLife #AcademicChatter #phd #phdposition #ChemTwitter
A new paper by the Luedtke lab @BioconjChem reports high yield (over 90%) bioconjugation of duplex #DNA. Congrats to Kaleena @McGillChemistry and Anna @UZH_Chemistry! Long NMR nights finally paid off!! Grateful to have made a small contribution.
pubs.acs.org/doi/10.1021/acsβ¦
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I'm excited to share our latest publication with all of you! "Sequence-Specific Fluorescence Turn-On Sensing of RNA by DNA Probes Incorporating the Tricyclic Cytidine Analogue DEAtC." Congrats to a big team of student co-authors. #RNA #SDSU #USD ππ₯³ pubs.acs.org/doi/10.1021/acsβ¦
In our new paper published at @BioconjChemΒ we have reported a new fluorescent cytidine analog which has the same pKa as dC, remains bright in different #DNAΒ structures & detects (even local) #imotifΒ formation.
@McGillChemistry @CRBSMcGill #Luedtke_lab
pubs.acs.org/doi/abs/10.1021β¦
About 2 yrs ago I got the chance to mentor @wang_kaixiang, an incredible BSc student at @McGillChemistry who was willing to work over Xmas holidays. His hard work in #Luedtke_lab just resulted in a paper we published together (he is co-1st authorπΎ) with Kaleena & @WilliamCopp16
About 2 yrs ago I got the chance to mentor @wang_kaixiang, an incredible BSc student at @McGillChemistry who was willing to work over Xmas holidays. His hard work in #Luedtke_lab just resulted in a paper we published together (he is co-1st authorπΎ) with Kaleena & @WilliamCopp16
Welcome to the new member of #Luedtke_lab @wang_kaixiang who just started his adventure in #DNA chemistry wonderland with a glycosylation reaction! ππ
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Yesterday, some1 was telling me his experience of submitting a paper during his PhD which was frm a femous lab. The editor called the PI saying that he has received a similar paper. Hwevr, he can delay that n get this 1 published if they can address a few questions quickly. 1/3
As an @AvHStiftung postdoc fellow who brings money (and knowledge) to @TU_Muenchen, I'm not eligible to use the MS-office app under the university's license :) Because they take me as a "guest researcher" and not a "real" postdoc... TUM you're NOT doing great!
In the season of carnival, the Krapfen is king!!!
Fasching is here at @robotic_dna
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How do #DNA #nanorobots store and release mechanical energy by winding up and relaxing a molecular torsion spring? Check out our team's just-published paper in @NaturePhysics!
@SimmelLab @TU_Muenchen
nature.com/articles/s41567-0β¦
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araF-C is back!
From the creators of the acclaimed studies on βaraF-C stabilizes i-motifsβ and βaraF-C slows down hybridization of i-motifs-forming seqsβ,
we present: βaraF-C traps i-motif folding intermediatesβ published with @SpringerNature in @CommsChem
rdcu.be/c5J4M
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Itβs the story of struggle in academia and an inspiration for all of us.
Robert Langerβs discovery was groundbreaking. And yet it was rejected.
#AcademicTwitter #chemicalengineering #research
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Very proud of our new paper! "Small MoleculeβTemplated DNA Hydrogel with Record Stiffness Integrates and Releases DNA Nanostructures and Gene Silencing Nucleic Acids". I think we made a genuinely interesting material which is well-behaved and "smart" onlinelibrary.wiley.com/doi/β¦ (1/2)
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How long and how much it takes from idea to publication?
Here is my tale of three molecules that I designed more than 11 years ago.
Bringing some Swiss spirituality to my new home @robotic_dna @TU_Muenchen after mission was accomplished at @McGillChemistry!
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We built a gingerbread MerMade! Our farewell to Dr. Adam Katolik, our MerMade expert forever! @CgssMcGill β at MontrΓ©al, QuΓ©bec
