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High-confidence peptide ID ≠ high-confidence PTM localization.
Our new research letter in BBA - Proteins and Proteomics highlights how co-eluting collagen PTM isoforms challenge site-specific LC–MS/MS analysis.
📖 doi.org/10.1016/j.bbapap.202…
@ScienceDirect
#Proteomics #MS #Collagen
Ayush Nigam retweeted
🍁🍂October at The Meshwork!
🔬 New ECM research
🎤 Researcher spotlights
📅 Breast cancer research webinar
🧰 new MatrixDB site
Science, people and connections — all in this month's newsletter.
📖 Read it in full here: shorturl.at/9Lmnd
Ayush Nigam retweeted
Check out this fresh piece in @jbiolchem the collaborative @CompCatLab @dkumar02 second step towards unraveling the mysteries of O-glycosylation in Collagen. Fantastic job by @GhoshSusovon9 and swapnila. @IntSocMatBio @amsocmatbio
Glad to share our review article ‘Structural and Mechanistic Insights into the Catalytic Versatility of Lysyl Hydroxylases in Collagen Post-Translational Modifications’ -JBC jbc.org/article/S0021-9258%2…
@AshokaUniv @TSB_Ashoka @trayambakbasak @CompCatLab @Swapnilapram1 @GhoshSusovon9
Ayush Nigam retweeted
🚨 New Meshwork Newsletter is out!
📅 Upcoming ECM events and Meshwork webinar w/ Brooke Farrugia and Jessica Chitty
🎙️ Spotlight: Prince David Okoro
🎓 PhD opportunities
We’d love to hear from you! Got a publication, news, or want to be a Spotlight Researcher? Get in touch 👇
Ayush Nigam retweeted
Replying to @Ashnig09
@Ashnig09 meticulously showed that coelution of collagen PTM peptides. An interesting observation posing a fundamental challenge for high-res MS analysis. Thanks for funding @DBTIndia @IntSocMatBio @amsocmatbio @ProteomicsIndia
High-confidence peptide ID ≠ high-confidence PTM localization.
Our new research letter in BBA - Proteins and Proteomics highlights how co-eluting collagen PTM isoforms challenge site-specific LC–MS/MS analysis.
📖 doi.org/10.1016/j.bbapap.202…
@ScienceDirect
#Proteomics #MS #Collagen
Happy to share that our book chapter, "Mass spectrometry-based mapping of the ubiquitin chaperone code," has been published in Methods in Enzymology.
doi.org/10.1016/bs.mie.2026.…
@ScienceDirect
#Proteomics #MassSpectrometry #Ubiquitination
Ayush Nigam retweeted
This book brings together in some ways the growing Matrix Biology community in India, with contributors across institutitions. Thrilled to have been able to help put this together with @AdhesionLab
Ayush Nigam retweeted
1/5
Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body.
biorxiv.org/content/10.64898…
Ayush Nigam retweeted
Final days to secure your spot for this exciting webinar on Monday, April 27 on "Stromal Architects: ECM, Fibroblasts, and the Cancer Niche" with @ednacukierman and @Yash_Chhabra @FoxChaseCancer !!! Register now! forms.gle/7LoqzKp891PQeKzE7
🚨 New webinar alert!
Join us on April 27 for a deep dive into tumor–stroma interactions with the experts:
🧬 @ednacukierman & @Yash_Chhabra @FoxChaseCancer
🕘 9AM EST / 3PM CEST
📍 Zoom
Save your spot: forms.gle/sjXBTYbtGopLSv3J8
More info 👇
Ayush Nigam retweeted
#researcherspotlight Ashutosh Joshi @j__ashutosh and Ayush Nigam @Ashnig09 from Dr. Trayambak Basak @trayambakbasak lab @CompCatLab IIT Mandi @iit__mandi talks about their work on "Intra-tissue specific collagenome PTM heterogeneity" @BiochemistryACS biopatrika.com/academia/rese…
Ayush Nigam retweeted
📣March newsletter is out now!
You can find updates on ECM seminars & conferences, job opportunities and a Spotlight Researcher interview w/ Zahra Sarmadian.
We dedicate this newsletter to Dr. Richard Hynes, read the full in memoriam in Matrix Biology.
Full newsletter link👇
Ayush Nigam retweeted
Check out this intratissue-specific collagen PTM heterogeneity study by MTech Bioengg Student @Ashnig09, mentored by graduate scholar @j__ashutosh!! Collab @CompCatLab @BiochemistryACS pubs.acs.org/doi/full/10.102… Funding @ANRFIndia @IntSocMatBio @amsocmatbio
Happy to share our work on intratissue-specific collagen PTM heterogeneity in @ACSPublications Biochemistry.
Thanks to @trayambakbasak for guidance, @j__ashutosh for mentoring, and @ANRFIndia for support.
#Proteomics #MassSpectrometry #Biochemistry #IntraTissueSpecificity
Check out this intratissue-specific collagen PTM heterogeneity study by MTech Bioengg Student @Ashnig09, mentored by graduate scholar @j__ashutosh!! Collab @CompCatLab @BiochemistryACS pubs.acs.org/doi/full/10.102… Funding @ANRFIndia @IntSocMatBio @amsocmatbio
Ayush Nigam retweeted
Join us for another exciting session with @NystromLab in two days!!! Still time to register: forms.gle/th1sShQd4CPZ5mcB8
📢 Upcoming webinar!
🔬 What therapies can tell us about fibrosis
@NystromLab (University of Freiburg) on how therapies and rare skin diseases reveal mechanisms of fibrosis + ECM remodeling
🗓 Mar 25, 2026
⏰ 3pm CET | 10am NY
💻 Zoom
Register ⬇️ forms.gle/ryWj3AwxeLSPWoK8A
Ayush Nigam retweeted
📣 New Jan-Feb Meshwork Newsletter is live!
From ECM seminars & conferences to job openings and a Spotlight Researcher interview w/ Mayuri Dutta, this issue is packed w/ updates across the community. 👉 Full newsletter: themeshwork2020.wixsite.com/…
Ayush Nigam retweeted
Join us for another exciting seminar on February 26th! 🔬
This month's speakers Dr. Matt Jones (@DrMCJones33 ) and his PhD student Nikita Mildren will cover ECM adhesion across the cell cycle!
Register by scanning the QR code or via the link: forms.gle/bkwmfwSsuKrtBn9v9
Ayush Nigam retweeted
Women make up only ~33% of researchers worldwide. Science needs more women & women deserve science without barriers. On #IDWGIS, we celebrate their achievements — and commit to building a more inclusive research community. #WomenInScience #EquityInScience






























