Researcher | Collagen Structure | QM/MM Simulation | DFT
IIT Mandi
Joined May 2022
- Tweets167
- Following196
- Followers98
- Likes576
Ashutosh Joshi retweeted
Yet another paper with made-up data. What happens now? #sciencecrisis #NatureRipoffs @Nature pubpeer.com/publications/67E…
Ashutosh Joshi retweeted
Why do some nitrene transfer catalysts show exceptional selectivity?
Our @Wiley_Chemistry Encyclopedia article highlights computational insights into enzymes & biomimetic catalysts.
Thanks to my supervisor @CompCatLab & the editors!
onlinelibrary.wiley.com/doi/…
#CompChem #Catalysis
Ashutosh Joshi retweeted
We are hiring a lot on the ML research front at our company, Boltz, in London!
A very formative period on that side right now.
If you want to build our next generation of models like this, let us know: boltz.bio/boltzmol-boltzprot…
Just email us, contact details below! 👇 1/2
Ashutosh Joshi retweeted
How do structural features govern the catalytic mechanism of lysyl hydroxylases? Explore our latest review in @jbiolchem with @trayambakbasak and @dkumar02. Great effort by @GhoshSusovon9 and @Swapnilapram1!
Glad to share our review article ‘Structural and Mechanistic Insights into the Catalytic Versatility of Lysyl Hydroxylases in Collagen Post-Translational Modifications’ -JBC jbc.org/article/S0021-9258%2…
@AshokaUniv @TSB_Ashoka @trayambakbasak @CompCatLab @Swapnilapram1 @GhoshSusovon9
Ashutosh Joshi retweeted
A prelude: Glimpses of Structure guided reactivity of the human lysyl hydroxylases. Check out our review now online at @jbiolchem. Thanks to the professors @CompCatLab @trayambakbasak and @dkumar02 for the guidance, and congratulations to @Swapnilapram1.
How do structural features govern the catalytic mechanism of lysyl hydroxylases? Explore our latest review in @jbiolchem with @trayambakbasak and @dkumar02. Great effort by @GhoshSusovon9 and @Swapnilapram1!
Ashutosh Joshi retweeted
Glad to share our review article ‘Structural and Mechanistic Insights into the Catalytic Versatility of Lysyl Hydroxylases in Collagen Post-Translational Modifications’ -JBC jbc.org/article/S0021-9258%2…
@AshokaUniv @TSB_Ashoka @trayambakbasak @CompCatLab @Swapnilapram1 @GhoshSusovon9
Ashutosh Joshi retweeted
Excited to share our recent review article that brings together emerging insights into collagen O-glycosylation. Grateful to @trayambakbasak , @dkumar02 and @CompCatLab for their constant guidance and support and @GhoshSusovon9 for the collaboration and shared efforts.
Glad to share our review article ‘Structural and Mechanistic Insights into the Catalytic Versatility of Lysyl Hydroxylases in Collagen Post-Translational Modifications’ -JBC jbc.org/article/S0021-9258%2…
@AshokaUniv @TSB_Ashoka @trayambakbasak @CompCatLab @Swapnilapram1 @GhoshSusovon9
Ashutosh Joshi retweeted
From Synthesis to Calculations—one student led it all. Excited to share our @JACS_Au article on harnessing iodonium ylides in metalloradical catalysis. Congrats to @Nnavi1sahota! Synergistic collaboration with @CompCatLab. Thanks @ANRFIndia for ARG grant.
pubs.acs.org/doi/10.1021/jac…
Ashutosh Joshi retweeted
Metalloradical catalysis via Fe-porphyrin-carbene intermediate! Kudos to @Nnavi1sahota for single-handedly leading the synthesis and calculations. Enduring collaboration with @PABLAB_iitmandi, with more to come! Thanks to @ANRFIndia and @iit__mandi. pubs.acs.org/doi/10.1021/jac…
Ashutosh Joshi retweeted
ERC-Funded Postdoctoral Position in Computational Biology
Uppsala University - Uppsala, Sweden
Read the full job description and apply⤵️
jobrxiv.org/job/erc-funded-p…
The book chapter reviews the fundamental principles of DFT & NBO that has been employed to investigate the role of PTMs in collagen helicity & stability. I thank my supervisors @trayambakbasak and @CompCatLab for their guidance & opportunity! DOI: 10.1007/978-3-032-22618-1_8
Ashutosh Joshi retweeted
For decades, biology textbooks have enshrined a simple rule: DNA is made by copying a template. After one enzyme unzips a DNA double helix into separate strands, another called a polymerase builds a complementary sequence, base by base, for each strand. Presto: two copies of the original DNA.
But new research into how bacteria defend themselves from viruses now shows this synthesis rule isn’t absolute.
Now, a team describes a bacterial enzyme that synthesizes DNA without a nucleic acid template, using its own structure as a guide.
Learn more: scim.ag/4tTc5IA @NewsfromScience
Ashutosh Joshi retweeted
1/ Excited to share our new paper in Science: “Toward life with a 19-amino acid alphabet through generative artificial intelligence design.” @ColumbiaSysBio @ColumbiaBME @Columbia
science.org/doi/10.1126/scie… 🦠🧬🛠️🖥️💥
Ashutosh Joshi retweeted
We don't even design binders!!
But we @BioMandrake just won @adaptyvbio × @gembioworkshop's RBX1 design competition - 1 Strong binder out of 322 tested, selected from 12,000+ submissions.
Couldn't make it to @iclr_conf in Rio. Here's how we did it 👇
open.substack.com/pub/mandra…
Ashutosh Joshi retweeted
1/ Excited to share our new Review in @Nature:
“The past, present and future of de novo protein design.”
Here, we mainly focused on structure-guided protein design. The field is entering a new phase: now that we can design new proteins, what should we build next?
Ashutosh Joshi retweeted
Excited to report the first de novo enzyme catalyzing two of the most energetically demanding reactions in biology—phosphomonoester and phosphodiester hydrolysis—with catalytic efficiencies comparable to natural enzymes! 🚀
desB was designed zero-shot with dEVA. No structure prediction, no pre-defined motif, no reaction-intermediates. 🧵
@StanfordBiosci @bioe_stanford @SLAClab
@EPFL @hes_so @simonduerr
Ashutosh Joshi retweeted
A 4 year post-doc position is available in the Sutherland group to work on novel fluorescent amino acids and peptides. Closing date for applications is 26th May. See here for more details and how to apply: jobs.gla.ac.uk/job/research-…
Ashutosh Joshi retweeted
#researcherspotlight Ashutosh Joshi @j__ashutosh and Ayush Nigam @Ashnig09 from Dr. Trayambak Basak @trayambakbasak lab @CompCatLab IIT Mandi @iit__mandi talks about their work on "Intra-tissue specific collagenome PTM heterogeneity" @BiochemistryACS biopatrika.com/academia/rese…
Ashutosh Joshi retweeted
Happy to share our work on intratissue-specific collagen PTM heterogeneity in @ACSPublications Biochemistry.
Thanks to @trayambakbasak for guidance, @j__ashutosh for mentoring, and @ANRFIndia for support.
#Proteomics #MassSpectrometry #Biochemistry #IntraTissueSpecificity
Check out this intratissue-specific collagen PTM heterogeneity study by MTech Bioengg Student @Ashnig09, mentored by graduate scholar @j__ashutosh!! Collab @CompCatLab @BiochemistryACS pubs.acs.org/doi/full/10.102… Funding @ANRFIndia @IntSocMatBio @amsocmatbio
