NEW imagining study (REACT STUDY) on SILENT ATHEROSCLEROSIS in over 16,000 adults without a history of established CVD. *Prospective ongoing study but this data is from a single time point (cross-sectional)* All subjects underwent "three-dimensional vascular ultrasonography of the carotid and femoral arteries and with coronary computed tomographic angiography". Some early call outs: 1 - There was a BIG change in atherosclerosis prevalence from age 30 to 40. Almost triple the number of male subjects at age 40 had measurable atherosclerosis in at least one of the 3 measured territories compared with subjects at age 30. This looks like a very important decade. At age 40 average coronary plaque volume was 50mm3 (it's unclear in the methods section how this was quantified - need to dig into it more). Also interesting at age 40, male and female calcium score is similar - around 10. But from this point they diverge with male calcium score being significantly greater than female calcium score each decade thereafter. 2- A clean CT Angiogram doesn't = no atherosclerosis. In fact middle age men were more likely to have carotid plaque. 3 - Overall women tend to have much less absolute plaque volume, however this isn't normalised for vessel size. I'd like to see a comparison of stenosis. A great new data set to explore. Cc @NutritionMadeS3 @Drlipid @ethanjweiss @RonKarlsbergMD @RonBlankstein @BudoffMd