We are proud to share our latest study published in Science. After achieving efficient and clinical feasible microglia replacement for the first time in 2020 (PMID: 32783928), we applied this strategy to treat a severe and fatal neurological disease, ALSP, and observed remarkable therapeutic effects—not only in the mouse model, but also in clinical trials involving 8 individuals with ALSP and up to 24 months of follow-up. This marks the first-in-human clinical application of microglia replacement therapy and suggesting its therapeutic effects in more neurological diseases. Check out the study at science.org/doi/10.1126/scie…

Efficient and safe peripheral macrophage replacement by Mr BMT expands the therapeutic potential of microglia replacement beyond the CNS eurekalert.org/news-releases…

We are pleased to announce the launch of the redesigned MicrogliAtlas! MicrogliAtlas is a dedicated database for mouse microglia, bringing together five atlases: aging, 3xDR-induced aging, repopulation, replacement, and ALSP disease. Spanning aging, cellular turnover, and disease, the platform provides a comprehensive, accessible resource for exploring microglial data. Our previous R/Shiny-based infrastructure experienced slow loading times and occasional accessibility issues. To address these limitations, our team has rewritten the underlying code, substantially improving performance and stability. Pages now load almost instantly, and gene queries return results rapidly, making data exploration smoother and more efficient. The redesigned website is currently in its trial phase, and additional datasets and atlases will be made available progressively. We thank our team members for their dedication and hard work. We warmly invite microglia researchers to explore MicrogliAtlas. We hope MicrogliAtlas will become your reliable friend and a valuable tool for your microglia research. MicrogliAtlas.com

As the most widely used strategy for microglia replacement, Mr BMT (aka mrBMT) enables simultaneous replacement of CNS parenchymal microglia and peripheral macrophages. While previous studies have focused primarily on the CNS, its impact on the peripheral macrophage system has remained largely unexplored. In our new paper in Advanced Science, we show that Mr BMT establishes durable, systemic macrophage replacement across peripheral organs while preserving overall tissue homeostasis. This work potentially expands the scope of microglia replacement, from CNS disease treatment toward broader systemic disease intervention. Let’s push microglia replacement forward, and shape what comes next. advanced.onlinelibrary.wiley…

I’m happy to be formally selected as the category winner in neuroscience for the 2026 𝗧𝗮𝗸𝗲𝗱𝗮 𝗜𝗻𝗻𝗼𝘃𝗮𝘁𝗼𝗿𝘀 𝗶𝗻 𝗦𝗰𝗶𝗲𝗻𝗰𝗲 𝗔𝘄𝗮𝗿𝗱 𝘄𝗶𝘁𝗵 𝗡𝗮𝘁𝘂𝗿𝗲 @TakedaPharma @Nature, in recognition of my pioneering contributions to 𝗺𝗶𝗰𝗿𝗼𝗴𝗹𝗶𝗮 𝗿𝗲𝗽𝗹𝗮𝗰𝗲𝗺𝗲𝗻𝘁. nature.com/immersive/innovat…

I’m happy to be selected as a shortlisted finalist in neuroscience for the 2026 𝗧𝗮𝗸𝗲𝗱𝗮 𝗜𝗻𝗻𝗼𝘃𝗮𝘁𝗼𝗿𝘀 𝗶𝗻 𝗦𝗰𝗶𝗲𝗻𝗰𝗲 𝗔𝘄𝗮𝗿𝗱 𝘄𝗶𝘁𝗵 𝗡𝗮𝘁𝘂𝗿𝗲 @Takeda @Nature, in recognition of my pioneering contributions to 𝗺𝗶𝗰𝗿𝗼𝗴𝗹𝗶𝗮 𝗿𝗲𝗽𝗹𝗮𝗰𝗲𝗺𝗲𝗻𝘁. This award celebrates groundbreaking research by early career scientists who are advancing the frontiers of scientific discovery in the areas of gastrointestinal and inflammatory diseases, neuroscience, and oncology. Takeda will award three category winners – one from each area of focus – in February, and one grand prize winner in April. I’m honored to receive this recognition and I’m excited to participate in Nature’s career development programs, while building meaningful connections with my peer awardees. nature.com/immersive/innovat… linkedin.com/company/takeda-… linkedin.com/company/naturep…

We are delighted to share our newly published Perspective review on microglia replacement in Cell Stem Cell @CellStemCell. This comprehensive article provides an in-depth overview of most key aspects of microglia replacement, including its concept, history, mechanistic principles, implementation strategies, relevant microgliopathies, applications, clinical trial, and future directions. We hope this review serves as a valuable resource for the community of microglia biology, neuroimmunology, and cell therapy. Find the full article here: cell.com/cell-stem-cell/full…

Latest Nature News of microglia replacement. Swapping old immune cells in the brain with fresh ones could treat disease nature.com/articles/d41586-0…

Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia replacement holds far-reaching potential for treating a wide range of neurological diseases. Let’s change the world and make this happen!

Microglia to the Rescue | Science | AAAS science.org/content/blog-pos…

Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia replacement holds far-reaching potential for treating a wide range of neurological diseases. Let’s change the world and make this happen!