@CLShafferPhD

Molecular microbiologist investigating mechanisms underlying bacterial secretion system assembly and function - Associate Professor @universityofky

 Lexington, KY
shafferlab.com
Joined May 2012
  • Tweets179
  • Following349
  • Followers378
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🙏🏻 Roberto for this beautiful & inspiring piece 👏 Monod, Jacob, Luria etc said that Existentialism was the only honest philosophical choice for scientists. Instead, I growingly feel also oriental wisdom & its emphasis on non-dualism as the right way to go journals.asm.org/doi/10.1128…

Asking a question | Journal of Bacteriology

The initial idea of this essay dates back to several years ago, perhaps more than I care to admit. In his role as co-director, George O'Toole asked me to give a lecture in the Woods Hole Microbial...

journals.asm.org
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Discovering molecular paradigms of microbial carcinogenesis nature.com/articles/s41579-0… In this Journal Club, @CLShafferPhD discusses a study revealing that infection with CagA-positive H. pylori strains is associated with an increased risk of developing stomach adenocarcinoma.
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Honored to write this piece for @NatureRevMicro highlighting the contributions of @BlaserLab, @CoverLabVUMC, and many other Helicobacter pioneers to the discovery of microbial determinants of gastric cancer rdcu.be/dIrVJ
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Thank you so very much to @AudeBer for my incredible visit to @institutpasteur - a microbiologist’s dream! 🔬
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😬😬😬😬
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Incredibly proud of the first PhD graduate from the Shaffer Lab - her future is bright! 😎🎉 Congrats to Dr. Mackenzie Ryan!
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Super excited to share the latest pre-print from the Shaffer lab - we mechanistically characterized asymmetric architectural features that enable DNA substrate selection and trans-kingdom conjugation through the cag T4SS. I'm so proud of my amazing team! biorxiv.org/content/10.1101/…

Architectural asymmetry enables DNA transport through the Helicobacter pylori cag type IV secretion...

Structural asymmetry within secretion system architecture is fundamentally important for apparatus diversification and biological function. However, the mechanism by which symmetry mismatch contrib...

biorxiv.org
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Architectural asymmetry enables DNA transport through the Helicobacter pylori cag type IV secretion system biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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Thank you @MBlokesch and @valdi001 for the best GRC! Can’t wait for 2025!
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Carrie Shaffer retweeted
Andreas Baumler@abaumler17 Jun 2023
To introduce you to some of the brightest early-career scientists in our field, @ASMicrobiology 's Infection and Immunity released an open call for nominations in 2022. We are proud to present this year’s selection of outstanding early-career scientists: journals.asm.org/topic/sss-t…
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So incredibly proud of my PhD student giving her first talk in front of a packed house at @MMPConference 2022! She killed it. I’m so excited for her future!
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Carrie Shaffer retweeted
Jensen Lab@theJensenLab18 Jul 2022
Our paper with @CLShafferPhD, @sigalby and @IlanRosenshine labs on a novel and widespread bacterial structure related to the type III secretion system is out now in @JBacteriology: doi.org/10.1128/jb.00144-22 Congrats to @MohammedKaplan_ and all authors!
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Discovery of a Novel Inner Membrane-Associated Bacterial Structure Related to the Flagellar Type III Secretion System @JBacteriology from @theJensenLab With @BriegelAriane @sigalby @MorganBeeby @yiweichang @CLShafferPhD @IlanRosenshine and many more journals.asm.org/doi/10.1128…
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I am so excited to share our latest work from the Shaffer Lab! In this manuscript, we describe how the gastric bacterium Helicobacter pylori stimulates STING signaling via cag T4SS-dependent mechanisms. biorxiv.org/content/10.1101/…

Helicobacter pylori provokes STING immunosurveillance via trans-kingdom conjugation

Recognition of foreign nucleic acids is an evolutionarily conserved mechanism by which the host detects microbial threats. Whereas some intracellular bacterial pathogens trigger DNA surveillance...

biorxiv.org
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Carrie Shaffer retweeted
Dr. Seema Mattoo@MattooLab12 Jun 2022
This crew rocked today! “Unconventional Uses of the Conventional” session turned out great! Thank you to all speakers @MysorekarLab @CLShafferPhD Ankur Dalia @hsueh_brian @MarcLecuit & to attendees for great discussions! @ASMicrobiology #ASMMicrobe2022 – at Washington, DC
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Carrie Shaffer retweeted
Dr. Seema Mattoo@MattooLab12 Jun 2022
It’s gonna be awesome @ASMicrobiology #ASMMicrobe2022! Come check out these cool scientists & their cool talks! In-Depth Symposium, June 12, 8:15am, Rm. 152AB “Unconventional Uses of the Conventional” Speakers @MysorekarLab @CLShafferPhD @hsueh_brian @MarcLecuit & Ankur Dalia. – at Washington, DC
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I am so very proud of my trainees presenting at #ASMMicrobe2022! Amazing representation for the Shaffer Lab! @UKyMIMG
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Amazing talk this morning by @MysorekarLab describing beautiful work at the maternal-fetal interface
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We're happy to welcome Dr. Carrie Shaffer, @CLShafferPhD, to the MSU MMG department seminar series - Join us for an exploration of H. pylori's defenses against microbial infection! #Microbiology
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