@ChoLab_Synapse

Synapse & Therapeutic Discovery Lab in the Department of Basic and Clinical Neuroscience, @KingsIoPPN @KingsCollegeLon @UKDRI #Neuroscience #AlzheimersDisease

 London, UK
Joined August 2023
  • Tweets430
  • Following154
  • Followers132
67Media
Kei Cho Lab retweeted
The Royal Family
@RoyalFamilyJun 9
Congratulations to everyone who received honours at today’s Investiture ceremony, hosted by The Princess Royal at Windsor Castle. 🎖️🎉 Amongst recipients were... 🦿 Dr. Mark Williams OBE for services to prosthetics. 🤝 Dr. Nasser Kurdy OBE for services to community interfaith reconciliation. 👩‍🎨 Solange Azagury-Partridge MBE services to design.
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We are delighted to announce that IoPPN scientists Prof Ann McNeill and Prof Kei Cho have received a CBE and MBE in the King’s New Years Honours 2026👏 🔗Read more: kcl.ac.uk/news/new-years-hon…
Ann McNeill (left) and Kei Cho (right).

ALT Ann McNeill (left) and Kei Cho (right).

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Congratulations to our colleagues recognised in King Charles III's 2025 New Year Honours List ⬇️ 👏 Professor Ann McNeill 👏 Professor Jennifer Rubin 👏 Professor Paul Mizen 👏 Professor Tara Renton 👏 Professor Kei Cho 👏 Mr Lorenzo Garagnani 🔗👉 kcl.ac.uk/news/colleagues-re…
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Kei Cho Lab retweeted
@BrainComms@braincomms7 Aug 2025
Mitchell et al. report that phosphorylation-mimic Tau selectively weakens synapses in distal CA1 dendrites, impairing PSD-95 expression, dynamics and synaptic plasticity. Read at buff.ly/GYH9Hlr. @ChoLab_Synapse @KingsIoPPN @KingsCollegeLon @UKDRI @adpdnet
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First time in #SfN24 So excited for poster presentation on 8th Oct. Please come and chat with me. ✌️
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Scientists have developed potential therapies that selectively remove aggregated tau proteins and improve symptoms of neurodegeneration in mice, showing a promising approach for Alzheimer’s disease. More: orlo.uk/N50dm @UKDRI @MRC_LMB

New therapy that destroys tau tangles shows promise for Alzheimer’s

ukri.org
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Congratulations to Shankar and David who have been inducted into the Inventors Hall of Fame for the role they played in inventing Next Generation sequencing.
Inventors HOF@InventorsHOF24 Apr 2024
In 2000, to sequence a single genome took over a decade. However, thanks to the groundbreaking work of Shankar Balasubramanian & David Klenerman, results are achievable in a single day, & it has helped identify disease genes, advance our understanding of cancers & more. #NIHF2024
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New online! Biomarker-based staging of Alzheimer disease: rationale and clinical applications go.nature.com/3TjXoPq
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In @Nature today: 40Hz light and sound stimulation increases peptide release from interneurons, driving clearance of #Alzheimers protein via the brain’s glymphatic system. Study led by @DrLiHueiTsai, @mhmurdock1. picower.mit.edu/news/how-sen… @mitscience @mitbrainandcog

How sensory gamma rhythm stimulation clears amyloid in Alzheimer’s mice

Stimulating a key brain rhythm with light and sound increases peptide release from interneurons, driving clearance of Alzheimer’s protein via the brain’s glymphatic system, new study suggests.

picower.mit.edu
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Fighting #dementia stigma begins with raising awareness. #Alzheimers #quote
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'Nuclear-import receptors as gatekeepers of pathological phase transitions in #ALS/#FTD' @DrBilalKhalil @M_Linsenmeier @neuro_smith @ShorterLab @RossollLab @MayoClinicNeuro @PennMedicine #TDP43 bit.ly/3vMq22t
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Quantifying functional connectivity from wide-field mesoscopic Ca2+ imaging in awake mouse cortex shows spontaneous behaviors are represented by fast changes in both the magnitude and correlational structure of network activity @mjhigley @HBenisty et al. nature.com/articles/s41593-0…
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Avoiding bias in fluorescence sensor readout — a Comment article by Dmitri A. Rusakov go.nature.com/483nCKs
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Aberrant axon initial segment plasticity and intrinsic excitability of ALS hiPSC motor neurons dlvr.it/SzT4df

Aberrant axon initial segment plasticity and intrinsic excitability of ALS hiPSC motor neurons

Harley et al. show that the axon initial segment (AIS) is an important site of dysfunction in ALS hiPSC motor neurons. Structural and molecular changes combined with reduced homeostatic plasticity of...

cell.com
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Kei Cho Lab retweeted
Cell@CellCellPress28 Nov 2023
Now online! Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals dlvr.it/SzP6pT

Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals

Enhanced efflux of PGD2 across the BBB during prolonged sleep deprivation induces a cytokine-storm-like syndrome via the PGD2/DP1 axis. Sleep deprivation in mice that involves disruption of REMS and...

cell.com
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Our featured article this month is this review on tau-targeting therapies in Alzheimer disease - the authors provide an update on initial immunotherapy trials, new therapeutic candidates in clinical development, & consider future directions. Full PDF here: rdcu.be/dr6m2
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A Review in @NatRevNeurol examines the potential of key molecules in the pathophysiology as biomarkers of vascular cognitive impairment and dementia and considers the challenges of clinical translation. 🔒 go.nature.com/3utwmLH
This is figure 1, which shows pathophysiological processes of vascular cognitive impairment and dementia, their interactions and potential biomarkers.

ALT This is figure 1, which shows pathophysiological processes of vascular cognitive impairment and dementia, their interactions and potential biomarkers.

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Replying to @jenniesrenes
#KingCharlesIII presents the members of the #KPop band #Blackpink with Honorary MBEs. Great news!!! Hope Blackpink also pay attention and campaign for global mental health issue (Photo from #BBC) All the best.👍👏
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Dynamical system 8: chaotic system. Here, neurons 1 and 2 spiral outward. At a certain threshold, neuron 3 turns on and kills the oscillation, restarting the spiral. Chaotic dynamics like this may characterize your brain as it is still learning a new task.
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Now Online Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology dlvr.it/SzH0wb
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