@ChowLab

Harnessing the power of natural variation --- Model organisms --- Disease modifiers --- ER stress --- Rare disease --- Dept. of Human Genetics / @UUtah

 Salt Lake City, UT
ChowLab.org
Joined March 2015
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Very excited to share our new paper on drug repurposing in a DPAGT1-CDG fly model: journals.plos.org/plosgeneti…. Thank you to everyone in the @ChowLab! More research in rare diseases and essential genes to come as a new Asst Prof in @KUMolBio.

A drug repurposing screen reveals dopamine signaling as a critical pathway underlying potential...

Author summary Some proteins require the attachment of sugars—like mannose and galactose—in order to perform their function. The process that attaches these sugars is called "glycosylation". Genetic...

journals.plos.org
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The @ChowLab is looking for postdocs! Lots of rare disease projects looking for genetic modifiers and drugs, all focused on translational potential. Opportunities to work in a basic science lab but interface with physicians, foundations, and families. static1.squarespace.com/stat…
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Check out new work from our lab!
Clement Chow@ClementYChow28 Oct 2024
NEW PAPER ALERT! @HansMDalton, former @chowlab postdoc, performed a drug repurposing screen in a fly model of DPAGT1 CDG, a disorder caused by mutations in the first step of N-linked glycosylation. 1/ journals.plos.org/plosgeneti…

A drug repurposing screen reveals dopamine signaling as a critical pathway underlying potential...

Author summary Some proteins require the attachment of sugars—like mannose and galactose—in order to perform their function. The process that attaches these sugars is called "glycosylation". Genetic...

journals.plos.org
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Hey #TAGC24! The @ChowLab is looking to hire everyone. Techs, postdocs, & research scientists! If you want to use or learn to use the fly to help people living with rare disease, find me! Read about how we’re using flies to find new rare disease medicines. uofuhealth.utah.edu/newsroom…

Rare But Not Forgotten

Finding treatments for children with rare diseases has been a significant hurdle in the medical world. An unexpected source, the common fruit fly, is turning up answers.

uofuhealth.utah.edu
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Great job, @HansMDalton!
Clement Chow@ClementYChow5 Jun 2023
Congrats to @ChowLab postdoc @HansMDalton on his successful K99 application! #funded
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Read about our newest partnership with @cureSYNGAP1!
Clement Chow@ClementYChow9 May 2023
A nice write up at @KSLcom about our partnership with @cureSYNGAP1 to try to find a possible therapy for SYNGAP1. Flies to the rescue. ksl.com/article/50638506/eye…

'Eye of the fly': How fruit flies could help find treatment for a rare genetic disease

A University of Utah researcher is using fruit flies — specifically studying their eyes — to screen drugs that could be used to treat patients with SynGAP-1, a rare genetic disease.

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“This is the time for rare diseases. In the next ten years, I think you’ll see therapies rolling out left and right because it’s just been waiting for the technology to be there. I think we have all the tools. What’s lacking is the funding.” – Clement Chow go.nature.com/3JOQ5Jv

Personalized medicine is having its day

Nature Biotechnology - From made-to-order genetic therapies to model organisms engineered to be ‘patient avatars’, the technology exists right now to save patients with rare diseases.

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It's so exciting that our science is having immediate real world impact in the lives of those living with rare diseases! So proud of the @ChowLab for working so hard at this.
Nature Biotechnology
@NatureBiotech20 Apr 2023
“This is the time for rare diseases. In the next ten years, I think you’ll see therapies rolling out left and right because it’s just been waiting for the technology to be there. I think we have all the tools. What’s lacking is the funding.” – Clement Chow go.nature.com/3JOQ5Jv

Personalized medicine is having its day

Nature Biotechnology - From made-to-order genetic therapies to model organisms engineered to be ‘patient avatars’, the technology exists right now to save patients with rare diseases.

nature.com
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