@DSLuciani

Associate Professor at @UBC, diabetes researcher at @BCCHresearch, islet biologist, mitochondria and lysosome lover, proud daddy

Joined February 2013
  • Tweets342
  • Following350
  • Followers440
7Media
A post over a decade in the making… 🙌beyond excited to share our work out today in @ScienceMagazine. We found that retrograde (mitonuclear) signaling regulates the identity and maturity of metabolic tissues.🧵 1/6 science.org/doi/10.1126/scie…

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues

Mitochondrial damage is a hallmark of metabolic diseases, including diabetes, yet the consequences of compromised mitochondria in metabolic tissues are often unclear. In this work, we report that...

science.org
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This is beautiful!
Austin E. Y. T. Lefebvre@Austin_Lefebvre21 Mar 2024
Attention organelle enthusiasts!! I am beyond thrilled to introduce Nellie: a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D/3D live-cell microscopy. paper: arxiv.org/abs/2403.13214 github: github.com/aelefebv/nellie 🧵1/N
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JDRF is supporting future leaders in the field of type 1 diabetes research through trainee and early career researcher awards. To see our new awardees and read about the 18 training grants currently active in Canada, visit jdrf.ca/trainee-awards/.

Trainee awards | Breakthrough T1D

breakthrought1d.ca
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🚨 Deadline alert! Don’t miss out on the SCN- @JDRF_Canada fellowship program in #Type1Diabetes! We’re looking for a post-doctoral scientist to pursue #StemCell & #RegenMed research focused on treating #T1D at the JDRF Centre of Excellence at @UBC 👇👇👇 stemcellnetwork.ca/training/…
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Universities are back in session and so is Parliament. I have heard from students and professors across the country - the challenges faced by graduate students are real. It’s time for our government to invest in graduate scholarships and in the granting councils.
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#TFEB and #TFE3 control #glucose homeostasis by regulating #insulin gene expression Andrea Ballabio, Gennaro Napolitano @G__Napolitano and colleagues @Tigem_Telethon embopress.org/doi/full/10.15…
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Data from mouse and human #islets using pharmacology and #genetics implicates Scn9a as a novel drug target to preserve β-cells in type 1 #diabetes #T1D @JimJohnsonSci @bcellorg @ biorxiv.org/content/10.1101/…
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What can't it do?! From regulating lipid metabolism to stress & immune responses to lifespan, nuclear hormone receptor (NHR)-49 has many roles in C elegans. 🪱 Read more in this @FrontiersIn review by @TaubertLab (@CMMT_UBC, @UBCAging, @BCCHresearch): bit.ly/3PoL7am
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Is 14-3-3 the Combination to Unlock New Pathways to Improve Metabolic Homeostasis and β-Cell Function? Read Here➡️doi.org/10.2337/db23-0094 @ADA_Pubs
Article Highlights

ALT Article Highlights

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1/13 I’m excited to share the pre-print of the main part of my PhD project titled “Pharmacological or genetic inhibition of Scn9aprotects beta-cells while reducing insulin secretion in type 1 diabetes” Click here: biorxiv.org/content/10.1101/…

Pharmacological or genetic inhibition of Scn9a protects beta-cells while reducing insulin secretion...

Pancreatic β-cells are critical for systemic glucose homeostasis, and most of them undergo cell death during the pathogenesis of type 1 diabetes. We previously showed that a Na+ channel inhibitor,...

biorxiv.org
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Dan Luciani retweeted
Jelena Kolic@JelenaK8630 May 2023
1/12 I’m delighted to share the pre-print describing my major post-doc project! Click here: medrxiv.org/content/10.1101/….

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease

Population level variation and molecular mechanisms behind insulin secretion in response to carbohydrate, protein, and fat remain uncharacterized despite ramifications for personalized nutrition. We...

medrxiv.org
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Very grateful for the support from @JDRF for this T1D research project and excited to do the work on stem cell-derived beta cells in collaboration with Dr Francis Lynn @nictitate at BC Children's Hospital Research Institute #bcchr
Breakthrough T1D Canada@BT1D_CA21 May 2023
JDRF is thrilled to announce that two Canadian researchers Dr. Hongshen Ma and Dr. Dan Luciani out of UBC have recently been awarded one-year Innovation Grants for their T1D studies in stem cell derived beta cells.  Read more here: bit.ly/45j7xzW
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Dan Luciani retweeted
CIHR
@CIHR_IRSC4 May 2023
Dr. @EJRideout and her team are studying sex differences in how insulin is affected in people with #Type1Diabetes. cihr-irsc.gc.ca/e/53357.html… @UBC @ubclifesciences
Dr. Elizabeth Rideout

ALT Dr. Elizabeth Rideout

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New from Prof Erin Mulvihill and colleagues- defining cell specific metabolic roles for DPP4 in the mouse pancreas @HeartInstitute @uOttawa @iScience_CP cell.com/iscience/fulltext/S…

Pancreas-derived DPP4 is not essential for glucose homeostasis under metabolic stress

Biological sciences; Physiology; Molecular biology; Cell biology

cell.com
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New roles for AMPK in control of lysosomal and mitochondrial biogenesis @ScienceMagazine science.org/doi/10.1126/scie…

Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1

The energy-sensing protein kinase AMPK also regulates organelle biogenesis.

science.org
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The Scientific Director of @CRCHUM, Dr. Vincent Poitout, will be on West Coast soil in June. The 2023ISG meeting will take place on the unceded territory of the xwməθkwəy̓əm (Musqueam) People. @VPoitout will update us on redox and lipids in the context of beta cell proliferation.
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Replying to @CraigAGoodman1
Thanks for tweeting this out Craig
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