PI @MGHCancerCenter, Assistant Professor @harvardmed. Studying T cell dysfunction using systems immunology and functional epigenomics

Boston, MA
Joined September 2018
Excited to share our latest preprint on how to rescue age-related T cell dysfunction in cancer! @AlexChenChangYu led an incredible effort using CRISPR screens to find genes that enhance T cell function and tumor control in aging. Brief explainer below: biorxiv.org/content/10.64898…
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@AlexChenChangYu and I want to thank our collaborators @MassGenBrigham, @MGBResearchNews, @harvardmed, @broadinstitute as well as @theNCI, @AmericanCancer, @MelanomaReAlli, @TheVFoundation for funding our work. We are very grateful for the support in these challenging times!
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Interested to know more? Please check out the full story here and reach out with any questions/feedback: biorxiv.org/content/10.64898…
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Hi! 👋I’m @vinidhra, Principal @FlagshipPioneer & Co-Founder/Head of Platform @ProFoundTx. I’m taking over our account in honor of International Women's Day to share more about my role, advice that has resonated with me in my career, & why the Flagship model is so unique. #IWD
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Super excited for our first lab publication @CellMetabolism! Led by superstar postdocs Tommy and Maolin who uncover an unexpected role for NRF2 in regulating NADH-reductive stress in lung cancer. Check it out at: authors.elsevier.com/a/1gemY…
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RFI alert from @NIH: We've all heard many concerns about #postdoc training: retention in academia, perceived decline in #s, salary... An @NIH Advisory Committee to the Director working group is exploring & has issued an RFI. Love your responses: grants.nih.gov/grants/guide/…
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Today is the International Day of Women and Girls in #Science. Read about female scientists worldwide as they reflect on their experiences and offer advice. #WomenInScienceDay #WomeninSTEM fal.cn/3vNEe
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New England Turkish Student Association (NETSA) and the Turkish Embassy is coordinating donations to support humanitarian relief as well as search & rescue efforts. Please make a donation if you can! donate.tpfund.org/team/48001… Other donation options at: ifrc.org/donate
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Debattama Sen retweeted
I ask for your help to support this Turkey Earthquake Fund gofundme.com/f/xh8d5t-turkey… that will directly help affected families in the region. Thanks everyone who reached out during these difficult times, truly appreciate and will never forget your support ❤️ Please share this 🙏
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Enjoy this fun tribute to reprogramming! 'Twas the night before Christmas by @emmapeterman_ Working with creative students is such a delight! 😍
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Debattama Sen retweeted
Really excited to share our new strategy combining deep learning predictions, epigenetic profiling, genetic perturbation to dissect gene regulatory elements at base resolution, and find transcriptional fulcrum in regulating immune response~ biorxiv.org/content/10.1101/…
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I am extremely enthusiastic to share our work published today in @NatureGenet. We establish a targeted @nanopore sequencing approach for ultralong-read epigenomic profiling and discover a novel, primate-specific enhancer driving bi-allelic IGF2 expression. nature.com/articles/s41588-0…
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