Glad to share this interesting Perspective article exploring how biofilm architecture could provide a framework to improve diagnosis, prognosis, and treatment stratification. This is an Editor's Choice article too in The ISME Journal! academic.oup.com/ismej/artic…
When imaging at high mag using cryo-ET, field of view reduces. How to overcome this limit? How do we get a "bird’s-eye view" without compromising resolution? Our very own @brown_hamish has a solution to this: “montage tomography with a rectangular beam!”
biorxiv.org/content/10.64898…
New preprint alert! 🦠🔬
We show how pathogenic bacteria form diverse, previously unknown biofilms within a dysregulated oral microbiome. A fascinating glimpse into how microbial communities may contribute to disease!
biorxiv.org/content/10.64898…
The big idea: We show disease-associated microbiomes form reproducible, distinct biofilms that may provide a new axis for predicting, diagnosing & targeting microbial disease.
So in microbiome, it is not just about WHO is there!
- it is about WHERE they are & HOW they organise!
Heroic effort from #AnanyaPadmakumar! Also, amazing collaboration involving #EricReynolds, #PaulVeith, #PaulMcMillan, #StuartDashper! Thanks to all the support from @UniMelb, @CCeMMP, @unimelbMDS, @CGCPT, @Bio21Institute, @Bio21Director.
Very pleased to see our recent work on the evolution of complex eukaryotic cells from simple microbial ancestors is featured in this @Nature News article. nature.com/articles/d41586-0….
Amazing to be a part of this fantastic work led by the @BurnsBrendan2 lab! Here, for the first time, we visualized unique viruses associated with Asgard archaea using cryoET. You can read it here: lnkd.in/gs7mztKw
Had an amazing day at the @Sydney_Uni, presenting our work at the SABA BacChats Seminar Series! Great scientific discussions throughout the day. Thanks again for the warm hospitality, I thoroughly enjoyed the visit! @DoyleMT1 and @bilgespqre, thank you both for everything.
New paper alert!! 📣
We just discovered a new filament system that is widespread exclusively within CPR bacteria! biorxiv.org/content/10.64898…. Short thread below. 🦠🔬🚀 ❄️
This study further highlights the power of integrating advanced cryo-EM with computational structural biology to assign functions to the vast repertoire of proteins encoded within microbial “dark matter,” where conventional annotation approaches often fall short.
Terrific effort led by @luca_troman with support from #JackKim, @Dr_MDJohnson, #JaysonRose. Amazing collaboration with @PetrovskiLab and @BanfieldJill.
@FMDHS, @UniMelb, @CCeMMP, @Bio21Institute, @Bio21Director