A new Nature paper just delivered a shock to a long-lived oncology myth. 🔗 nature.com/articles/s41586-0… For years we’ve been told that radiotherapy—and its cousins like SBRT, TARE, Y-90—might trigger the “abscopal effect,” a systemic immune response that helps control distant disease. This study shows the opposite: radiation induces Amphiregulin (AREG) and can stimulate distant metastasis through myeloid-cell reprogramming. So what does this mean for HPB oncology? 👉 The “abscopal effect” is not a clinical strategy. It’s a story. 👉 Radiation-driven systemic benefit is, at best, unreliable—and at worst, misleading. 👉 Surgery remains the only method of local control with reproducible impact on survival.