Lung oncologist, tumor immunology & KRAS researcher, advocate for lung cancer patients and learners @pmcancercentre, @uoftmedicine, @UofT. He/Him/Il. πŸ³οΈβ€πŸŒˆ

Toronto, Ontario | Treaty 13
Joined October 2015
Setting the bar higher for KRAS inhibitors - pleased to share our study of divarasib in KRAS G12C lung/colon/solid tumors in @NEJM. Impressive response rate, durability and tolerability. Thanks to pts and co-investigators. @KRASKickers #lcsm
Among patients with cancers bearing the KRAS G12C mutation who received divarasib at a 400-mg dose, 56% with lung cancer, 36% with colorectal cancer, and 36% with other tumor types had a confirmed response. πŸ”— Read the full study results: nej.md/45xZYok #oncology

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A great visit to the @pmcancercentre @UHN and @UofT yesterday to kick off their Distinguished Speaker Seminar Series- thank you to my hosts, @CherylArrowsmi1 and @DocSacher for a wonderful day, along with many faculty and students and a chance to visit @claudiagentile_ in her new digs!! #cancer #chromatin #cancerbiology #seminar #mentorship #lecture @kadochlab
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Adrian Sacher, M.D. retweeted
Distinguished Speaker Seminar Series Highlights Cancer Research in Toronto - Cigall Kadoch @CKadoch oncodaily.com/voices/cigall-…
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🚨 Check our Top 10 #LungCancer abstracts for ELCC 2026! We've hand-picked the must-see sessions with times & presenters. πŸ—“οΈ Stay on track in Copenhagen and simply import these directly to your calendar by clicking this link: lungsummit.org/elcc2026.ics Which lung abstracts are your favorites at ELCC26 #LCSM @IASLC @myESMO
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πŸ“£ Updated ESMO #ClinicalPracticeGuideline on early & locally advanced #NSCLC: new systemic treatments, innovative strategies & advanced therapeutic options to personalise #PatientCare & improve outcomes. πŸ”— ow.ly/yU4i50WM0Uk #LungCancer #SystemicTherapy #Oncology #CancerTreatment
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πŸŽ™οΈ New #LungCancerVoices Podcast episode! @pwheatleyprice & @DocSacher talk about all there is to know about #KRAS lung cancer. What is KRAS, how it's tested, what it means in terms of treatment options for those who have this subtype. ▢️ Listen now at bit.ly/LCCPodcast
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Early phase trials: the perils of nonpublication @DocSacher @susanebates doi.org/10.1093/oncolo/oyaf0…
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It was a pleasure to spend the day @ASCO planning the metastatic NSCLC program with this amazing group (missing Toby Campbell). Looking forward to an exciting #ASCO25 !
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#ESMO24 concomitant paper: @DocSacher presents the First-in-human study of AMG 193, an MTA-cooperative PRMT5 inhibitor at today's Presidential Symposium @HPrenen
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Excellent summary of #KRASG12C trials in the metastatic NSCLC space by @DocSacher @ASCO #ASCO24 ✨ 2L tx TKI v. Docetaxel ✨ combination TKI + IO ✨ combination with chemo ✨ combination with EGFR Lot if interest in this space and congrats to all the authors @OncoAlert
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Excited for #ASCO24! While disease specific content is best found in oral session dedicated to a disease group, explore thematic Clinical Science Symposia that are a highlight - such as the special session on #KRAS In #NSCLC πŸ“Hall B1, Sat, Jun 1 @TonyMok9 @DocSacher @KCArbourMD
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Adrian Sacher, M.D. retweeted
Not one, not 2, but 3 lung cancer plenaries at #ASCO24 ! Early telemed pall care, the LAURA trial of consolidation osimertinib after CRT for stage 3 EGFR non small cell lung cancer & the ADRIATIC trial of consolidation immunotherapy after CRT for small cell lung cancer! #lcsm
#ASCO24 garnered a record number of abstract submissions! Preview the abstract titles to see what will be presented or published at this year’s meeting and browse the meeting program to start planning your schedule ➑️ brnw.ch/21wJ8kD
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Next up #TTLC24 Targeted Therapies: KRAS, BRAF, SHP2, SOS1 kicks off w/ @FSkoulidis @Dobeze_ @DrMarkAwad @AlexSpiraMDPhD @SukiPadda @kamarroneMD @NaglaAKarimMD @DocSacher @NIVokes!
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Pleased to participate in #Coalition4CdnResearch press conference with all Canadian advocacy groups coming together to call on the federal government to invest in research. @cafreeland @KirstyDuncanMP @JustinTrudeau
"It's past time for the government to make a major investment in Canadian research." - Dr. Brad Wouters, Executive VP Science & Research at @UHN, representing @HealthCareCAN, and a Research Canada Board Director Read #Coalition4CdnResearch's open letter: ow.ly/yXg450PTuPI
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Exciting new clinical findings from @DocSacher @pmcancercentre @UHN_Research demonstrating potential of targeting KRAS
Dr. Adrian Sacher (@DocSacher) @UHN co-led a multi-national effort to test a new anticancer drug in patients with non-small-cell lung cancer and colon cancer. With few serious side effects found, further testing is warranted. > uhnresearch.ca/news/advancin…; doi.org/10.1056/NEJMoa230381…
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🌟 Dr. @DocSacher's research uncovers potential treatments for lung cancer patients facing drug resistance. With LCFA backing, he takes crucial steps towards a brighter future for those battling lung cancer. #Livingwithlungcancer #WLCD23 #lungcancer bit.ly/44Czi5C
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πŸ”¬ Dr. @DocSacher's mission is to comprehend the body's immune response to cancer cells. With LCFA's support, he explores novel therapies that may transform treatment approaches. 🌱 #Livingwithlungcancer #LCFAmerica #LCFAResearch #WLCD23 #lungcancer bit.ly/44Czi5C
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The support of @lcfamerica and patients & their families has been essential to our ongoing work to end lung cancer. Thank you so much - great things to come!
πŸŽ“ As a Clinical Investigator and Assistant Professor, Dr. @DocSacher's impact on lung cancer research is undeniable. His dedication to immunotherapy brings hope to patients worldwide. πŸ† #Livingwithlungcancer #LCFAResearch #WLCD23 #lungcancer bit.ly/44Czi5C
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Adrian Sacher, M.D. retweeted
Canadian Consensus Recommendations on the Management of KRASm G12C #NSCLC #KRAS 🫁 πŸ”» doi.org/10.3390/curroncol300…
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