@DuSiling

Neuroimmu-enthusiastšŸ§GR6 IMM student in the Kipnis lab & Colonna lab at WashU| Studying brain macrophages & neurodegeneration | Re-tweet to learn

 St Louis, MO
Joined December 2018
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Out today in Immunity! Our pan-atlas of human immune aging: 12.4 million PBMCs from 2,609 people across 8 global cohorts (including new 188 people cohort from UK). cell.com/immunity/fulltext/Sā€¦ We map shared aging patterns onto 59 key immune populations and link the balance of GZMK+ and GZMB+ CD8 effector memory T cells to health trajectories; show differences in RTEs and Th2s with sex etc; ethnicity associated features. artyomovlab.wustl.edu/human-ā€¦ How it came to be: in 2023 we published first hierarchically annotatied atlas of human immune aging in PBMC - 166 people, 55 populations, key changes revealed - CD8 naives, KLRC2/NKG2C+ CD8 memory going down, GZMK+ CD8 T cells and Th2 and Tc2 type 2 memory cells going up! (Terekhova et al, Immunity 2023) in 2024 we added major phenotypes within naive cells - SOX4+ RTE cells and their CD38 marker going down. (Bohacova et al, Immunity 2024) In 2025-26 more atlases published with their own annotations making impossible to leverage power of data.. Now we provide unique in its power and consistency resource - 2600 people across ages, sexes, races, continents etc. All annotated in sync and analyzed for what aging looks like globally!
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Very excited to see this work published! Huge congratulations to Huma and the entire team for a wonderful study on microglial heterogeneity across aging, brain regions, and parabiosis.
Huma Naz@Dr_HumaNazAug 29
I am thrilled to share our new publication: "Core activation program and selective regional responsiveness of microglia during aging and parabiosis" doi.org/10.1016/j.celrep.202ā€¦ Grateful to all collaborators, special thanks @gzhao11 @TristanLi_Lab @NannanLu3 @wysscoray
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Feiya Ou@FeiyaOu1Aug 25
Glad to share that my preprint "ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer" is out today in @NatImmunol This represents another major piece of my PhD work. nature.com/articles/s41590-0ā€¦ Preprint thread: xitter.cf/FeiyaOu1/status/196363ā€¦

ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer

Nature Immunology - Murphy and colleagues report that the transcriptional regulator ID2 promotes cDC1 fate specification by antagonizing E protein activity at E-boxes within the Zeb2 enhancer and...

nature.com
Feiya Ou@FeiyaOu14 Sep 2025
šŸ§µ1/8 Happy to share my new preprint ā€œID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer.ā€ I resolved why ID2 is essential for cDC1 lineage specification and uncovered a new paradigm of enhancers. Read here: researchsquare.com/article/rā€¦

ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer

The transcriptional regulator ID2 is required for type 1 classical dendritic cell (cDC1) specification, yet the mechanism has remained obscure. We previously identified the Zeb2 -165-kb enhancer as...

researchsquare.com
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šŸ§µExcited to share my first author paper in @Nature from @kipnislab. "Functional role of skull lymphoid structures in CNS immunosurveillance" nature.com/articles/s41586-0ā€¦

Functional role of skull lymphoid structures in CNS immunosurveillance

Nature - Functional lymphoid structures within the skull bone marrow enable central nervous system immunosurveillance and shape immune responses to brain disease.

nature.com
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BryanRoth
@zenbrainestAug 19
Just DREADD-full Wake-activated neuronal populations that regulate sleep drive nature.com/articles/s41586-0ā€¦

Wake-activated neuronal populations that regulate sleep drive

Nature - Whole-brain activity mapping, targeted cell manipulations and electrophysiology in mice identify wake-activated neuronal populations that are crucial for sleep drive and can persistently...

nature.com
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Excited to share our new work by Jay Park @janghyun_park_ and friends! Jay found lymphoid structures in the skull bone marrow that seem to be serving immune hub role for the brain... brain, after all, may not be using "common lymph nodes" but rather has its own unique immune hubs and Jay showed their role in brain tumors... but their role in likely much more than that. This is a long paper but it is worth the read || nature.com/articles/s41586-0ā€¦

Functional role of skull lymphoid structures in CNS immunosurveillance

Nature - Functional lymphoid structures within the skull bone marrow enable central nervous system immunosurveillance and shape immune responses to brain disease.

nature.com
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šŸ”„šŸ”„New paper alert! Super excited to share our paper, out today in @NatureHumBehav, led by the wonderful @Nofar_Mizrachi nature.com/articles/s41562-0ā€¦ To me, this finding fundamentally changes how we should think about the relationship between cognition and immune regulation:

Voluntary attention regulates acute immune responses in humans

Nature Human Behaviour - Mizrachi et al. show that directing attention to bodily sensations, rather than away, promotes more regulated acute inflammatory responses in healthy volunteers, revealing...

nature.com
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Julia Belk
@juliabelkAug 14
Finally, I want to highlight elegant and complementary stories from Helena Barr, @stevens1lab, Hernandez Moura Silva, Juan Lafaille, Rahul Nagvekar, and @BrunetLab, further underscoring the importance and unique functions of brain macrophages. 6/6 biorxiv.org/content/10.64898ā€¦ biorxiv.org/content/10.64898ā€¦ elifesciences.org/reviewed-pā€¦

The circadian clock regulates scavenging of fluid-borne substrates by brain border-associated...

Circadian disruptions perturb the brain and immune system and increase the risk of developing Alzheimerā€™s Disease (AD), yet whether this involves dysregulation of brain immunity remains less clear....

biorxiv.org
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Julia Belk
@juliabelkAug 14
The transcription factor MAF is known from human genetics to be important in Alzheimerā€™s disease, but its precise function within the brain has been unclear. Our latest, out today in @CellCellPress, dissects the role of MAF in brain macrophages. 1/ cell.com/cell/fulltext/S0092ā€¦

Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcript...

This study identifies cMAF as a key transcription factor that orchestrates the molecular crosstalk between brain perivascular macrophages and arteries, thereby sustaining cerebrovascular function in...

cell.com
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Steffen Storck@SEStorckAug 14
Out in @Cell today: In a collaborative effort across multiple labs, we found that cMAF controls the identity and function of perivascular macrophages critical for cerebrovascular function. cell.com/cell/fulltext/S0092ā€¦ A thread:

Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcript...

This study identifies cMAF as a key transcription factor that orchestrates the molecular crosstalk between brain perivascular macrophages and arteries, thereby sustaining cerebrovascular function in...

cell.com
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Soyon Hong@soyonhonglabJul 10
Thrilled to share: we show that neuronal hyperactivity drives C1q-mediated synapse loss via brain-recruited B cell/IgM, showing unexpected neuroimmune crosstalk in adult brain. CONGRATS to @Ger_Crowley13 who led w/ resilience & creativity & whole team! science.org/doi/10.1126/
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John Lukens@LukensJohnRMay 29
Decoding the spatiotemporal development of human meninges @CellCellPress cell.com/cell/fulltext/S0092ā€¦
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nature.com/articles/s41586-0ā€¦ -> organ specific ECM shapes identities of intrinsic nervous systems. v cool!

Lineage and organ signals sequentially build organ intrinsic nervous systems

Nature - Systems-level analyses of organ intrinsic nervous systems reveal that these networks are initially configured by lineage-dependent programmes, and their architecture and molecular identity...

nature.com
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Excited to share our new study out in @SciImmunology We show that Monocyte-derived Macrophages drive oxidative damage during neuroinflammation science.org/doi/10.1126/sciiā€¦

Monocyte-derived macrophages drive neurological tissue damage through mitochondrial reactive oxygen...

Quenching mitochondrial reactive oxygen species in monocyte-derived macrophages, but not in microglia, ameliorates neuroinflammation.

science.org
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Amy Fan@amycfanphdApr 29
Excited to announce our study (w/ @RukmanThota & @MaxKrummel) published today @Nature: Macrophages ā€œhold our living identitiesā€ by taking tiny bites from living cells and presenting this information to CD8 T cells. nature.com/articles/s41586-0ā€¦ #immunology #cellbiology @immunox @ucsf

Submicrometre sampling of living cells by macrophages

Nature - Macrophages can sample antigens from living cells through a trogocytosis-like mechanism that routes ingested material away from degradation, a finding that delineates a previously unknown...

nature.com
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John Lukens@LukensJohnRApr 21
Somatic cancer variants enriched in Alzheimerā€™s disease microglia-like cells drive inflammatory and proliferative states: Cell cell.com/cell/fulltext/S0092ā€¦
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Kika@v_moreno_juanApr 15
I am very happy to share that our paper is now published in @Nature šŸ˜Š Cell-type-targeted mitochondrial transplantation rescues cell degeneration. nature.com/articles/s41586-0ā€¦ @IOB_ch (1/6)

Cell-type-targeted mitochondrial transplantation rescues cell degeneration

Nature - MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

nature.com
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Just updated my HHMI Gilliam Fellowship application guide for the 2026 competition, which brings major program changes. Int'l PhD students can now apply. MD-PhDs are eligible. & a new postdoc pathway that can extend HHMI support up to 7 years total. yaelcourtney.com/resources-aā€¦

HHMI Gilliam Fellowship Application Guide (From a Gilliam Fellow) | Ya'el Courtney ā€” Ya'el Courtney

A detailed walkthrough of every component of the HHMI Gilliam Fellowship application ā€” from the equity and inclusion statement to the community engagement plan ā€” written by a three-year Gilliam...

yaelcourtney.com
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Jing Chen@JingNeticistApr 5
Giving a talk soon on open box science + microglia taking the road less traveled. We started with a question about how tissue-resident macrophages develop and ended up uncovering a distinct regulatory program: Maf and Jun drive Zeb2 during primitive hematopoiesis.
Open Box Science@OpenBoxSciApr 3
OBS Immunology Immune cell ontogeny, and functional specialization of immune cells šŸ”¹Laura JimĆ©nez Gracia, PhD @cnag_eu šŸ”¹Jing Chen @Jingneticist @washumedicine Moderator: @asalboix šŸ“… Tuesday, April 14 ā° 12 pm ET, 6 pm CET šŸ’» us02web.zoom.us/meeting/regiā€¦
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The Orange Cat Brain Atlas is here. šŸ§ šŸˆ Today, we published the first comprehensive cellular map of the orange cat brain. The new atlas reveals a single, specialized neuron responsible for behaviors like staring at walls, knocking objects off tables, and the 3am "zoomies."
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