Founder @objectivenutri Thiamine supremacist YouTube is my main platform: EONutrition
Joined June 2021
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Elliot Overton retweeted
J’ai entendu dire que la France était finie, qu’il était trop tard pour la sauver.
Mais la France est toujours aussi belle, enviable même. Sa grandeur n’a pas disparu, elle ne demande qu’à renaître.
Nous avons surmonté en un an un problème cent fois plus grave, sans avoir les moyens dont dispose la France.
La France pourrait y arriver en une semaine.
A recent study revealed a localized deficiency of thiamine in the brain of patients with the incurable neurogenerative condition, Huntington's Disease.
Researchers identified abberant changes in the transcription of a biotin-dependent transport protein (SLC19A3) which carries thiamine into the brain. Specifically, the region of the brain affected was the striatum.
Thiamine entry into cells requires a Biotin-dependent transporter. This is called SLC19A3, and it carries thiamine into brain cells. High-dose biotin raises SLC19A3 production in the brain and allows greater entry of thiamine
Patients with Huntington's diseas have been shown to have low thiamine levels in cerebrospinal fluid, and decreased concentrations of active thiamine (TPP) were also decreased in the striatum.
In this mouse model, the combination of high-dose thiamine and biotin (100mg/kg/d and 5mg/kg/d, respectively) prevented striatal shrinkage, neuron death, and restored active thiamine concentration in the affected brain regions.
These findings led authors to conclude:
"High-dose biotin and thiamine treatment prevented TPP deficiency in HD mice and attenuated the radiological, neuropathological, and motor HD-like phenotypes, revealing an easily implementable therapy that might benefit patients with HD"
It also provided the theoretical foundation for a human clinical trial, which is currently underway
Exciting times, indeed.
Study ref: 34586830
Clinical trial ID: NCT04478734
Elliot Overton retweeted
6 healthy volunteers drank ~1.13 L of beer providing ~600 μmol of monosilicic acid. Within 8 hours, they excreted ~56% of the ingested silicon (range 42–75%), with a concurrent, statistically significant rise in urinary aluminum excretion (p <0.05).
Elliot Overton retweeted
Just read a critique that health Twitter is launching too many D2C businesses and grifting too hard. But honestly I don’t think we’re grifting NEARLY hard enough.
Why are we stopping at D2C?? Why aren’t Aurabiōm, Sport Drink, SINA Crisps, Objective Nutrients, Anabology, Bloo, Shwally and every other legitimately good health brand born on this app in EVERY Whole Foods, Sprouts and supermarket in America? Why aren’t we putting our non-zogged better formulated, higher-quality products in front of millions of ordinary people?
We have an entire food, beauty and wellness industry to take over and we’re apparently wasting time arguing about who’s grifting whom.
Grind harder and grift harder, my friends. We have shelves to occupy. 📈📈📈📈📈📈📈📈📈❤️🔥
Elliot Overton retweeted
And now you understand why people have “gluten intolerance” and why the average age of cancer diagnosis has plummeted.
This guy was gonna die within 6 months
Discovers a radical treatment for heart disease buried in the scientific literature on mice
Treats himself and tracks all of his biomarkers
After less than 2 months:
- Right carotid plaque down by 36% and 27% - Triglycerides down by 75%
Convinced his doctors to pay attention and is still alive today 6 years later
Listen to what his doctors said
This case study is wild
Man told he has between 6 months and 2.5 years to live
Severe, end-stage atherosclerosis with multiple stents
Stumbles upon obscure treatment in a random mouse study
Orders it from some online company and starts injecting it intravenously
Tracks everything. After less than 2 months:
- Right carotid plaque down by 36% and 27%
- Triglycerides down by 75%
Still alive, and his name is Kyle Hodgetts
Goes on to coauthor and publish his n= 1 data in two papers
The “obscure treatment” = Beta-Cyclodextrin (hydroxypropyl-B-cyclodextrin)
A molecule with such widespread use that it essentially can’t be patented, and is currently being investigated in early trials for its efficacy on a wider scale. Indeed, it can be purchased by anyone online.
And it is entirely possible that it turns out to be a major challenge to multi-billion dollar statin industry, and it has very few reported side effects.
Kyle eventually set up a company making a version of cyclodextrin which can be administered rectally, due to its poor oral bioavailability.
The simplified proposed mechanism of action:
- Binds cholesterol esters and sterols, carries them out of the body (via urine)
- Dissolves cholesterol crystals
- Restore endothelial nitric oxide synthase
- Activates the LXR pathway
Of course, prevention via diet and lifestyle and then targeted supplementation with things like nattokinase, niacin, aged garlic extract, CoQ10, etc would obviously be the route to take in the early stages.
However, in the terminal stage, an intervention like this might end up being a major game changer.
References:
- 10.1126/scitranslmed.aad6100
- PMID: 27053774
- 10.29011/2575-7083.100262
- 10.1371/journal.pone.0338635
- 10.1016/j.atherosclerosis.2025.119217
- 10.1016/j.atherosclerosis.2025.119640
- NCT06813339
Case studies: heartfixer.com/Cyclodextrin.…
Elliot Overton retweeted
5 hours of surgery in Germany completely blew my mind.
What came out of my jaw proved that your dentist is likely wrong about dental care.
Learn from my experience before you let another dentist touch your mouth. 🧵
This case study is wild
Man told he has between 6 months and 2.5 years to live
Severe, end-stage atherosclerosis with multiple stents
Stumbles upon obscure treatment in a random mouse study
Orders it from some online company and starts injecting it intravenously
Tracks everything. After less than 2 months:
- Right carotid plaque down by 36% and 27%
- Triglycerides down by 75%
Still alive, and his name is Kyle Hodgetts
Goes on to coauthor and publish his n= 1 data in two papers
The “obscure treatment” = Beta-Cyclodextrin (hydroxypropyl-B-cyclodextrin)
A molecule with such widespread use that it essentially can’t be patented, and is currently being investigated in early trials for its efficacy on a wider scale. Indeed, it can be purchased by anyone online.
And it is entirely possible that it turns out to be a major challenge to multi-billion dollar statin industry, and it has very few reported side effects.
Kyle eventually set up a company making a version of cyclodextrin which can be administered rectally, due to its poor oral bioavailability.
The simplified proposed mechanism of action:
- Binds cholesterol esters and sterols, carries them out of the body (via urine)
- Dissolves cholesterol crystals
- Restore endothelial nitric oxide synthase
- Activates the LXR pathway
Of course, prevention via diet and lifestyle and then targeted supplementation with things like nattokinase, niacin, aged garlic extract, CoQ10, etc would obviously be the route to take in the early stages.
However, in the terminal stage, an intervention like this might end up being a major game changer.
References:
- 10.1126/scitranslmed.aad6100
- PMID: 27053774
- 10.29011/2575-7083.100262
- 10.1371/journal.pone.0338635
- 10.1016/j.atherosclerosis.2025.119217
- 10.1016/j.atherosclerosis.2025.119640
- NCT06813339
Case studies: heartfixer.com/Cyclodextrin.…
The cognitive and mood-boosting benefits of coffee go beyond caffeine, and some of it may stem from changes occuring in the gut
Study showed both caffeinated and decaffeinated coffee altered the gut microbiome and increased production of neuroactive metabolites, including:
- GABA
- indole-3-propionic acid
- indole-3-carboxyaldehyde
They found that caffeinated and decaf had different effects on behaviour:
- Caffeinated was associated with lower anxiety/distress and improved attention
- Decaf was associated with improvements in memory and sleep quality
Small study, but interesting nonetheless
DOI: 10.1038/s41467-026-71264-8
Elliot Overton retweeted
If you are taking thiamine, be sure you are also getting enough minerals (Mg, K, Na), other B vitamins, CoQ10, glycine, copper, selenium and molybdenum. Thiamine is remarkable, and is in general a fairly low risk supplement due to its water solubility... but in my experience most people do not really need to consistently supplement with high doses of thiamine (unless a severe neurological issue is present) for longer than a few months-a year, and unless you're careful it can deplete/upset the balance of other cofactors.
Elliot Overton retweeted
Leucovorin is the largest singularly effective treatment to gain speech in kids with autism according to over a dozen clinical trials. I see it regularly in my practice. It was also a game changer for my own ASD kids.
Severely autistic, non-verbal 4yo child is given high-dose folate (leucovorin)
- Gains speech in the first week and learns to walk
- Can speak 100 words after 1 year, maintains eye contact and physically active
- When he misses a dose, he relapses
This treatment is insane
Testimonial from a follower
Up to 76% of children with autism may actually have an autoimmune disorder which blocks uptake of folate into the brain, leading to a cerebral deficiency
Autistic children were 19 times more likely to test positive for folate receptor alpha antibodies, which bind with and block folate receptors at the blood-brain-barrier
These children had normal blood results, but very low levels in cerebrospinal fluid
Treatment with a specialized folate supplement, calcium folinate/folinic acid (aka Leucovorin), led to improvement in ~65% of autistic children studied
Standard testing is useless because blood levels of folate show up as normal, but the brain is deficient
Ordinary folate supplements (folic acid, methylfolate) are ineffective because their transport system is blocked
Calcium folinate, on the other hand, works by penetrating the brain via alternative transporters (reduced folate carriers) to effectively restore folate levels
However it must be taken in extremely high doses to achieve this effect. Leading physicians are using approx. 2mg/kg body weight.
Refs:
PMID: 38392599
PMID: 38248763
PMID: 34834493
PMID: 32892962
Up to 76% of children with autism may actually have an autoimmune disorder which blocks uptake of folate into the brain, leading to a cerebral deficiency
Autistic children were 19 times more likely to test positive for folate receptor alpha antibodies, which bind with and block folate receptors at the blood-brain-barrier
These children had normal blood results, but very low levels in cerebrospinal fluid
Treatment with a specialized folate supplement, calcium folinate/folinic acid (aka Leucovorin), led to improvement in ~65% of autistic children studied
Standard testing is useless because blood levels of folate show up as normal, but the brain is deficient
Ordinary folate supplements (folic acid, methylfolate) are ineffective because their transport system is blocked
Calcium folinate, on the other hand, works by penetrating the brain via alternative transporters (reduced folate carriers) to effectively restore folate levels
However it must be taken in extremely high doses to achieve this effect. Leading physicians are using approx. 2mg/kg body weight.
Refs:
PMID: 38392599
PMID: 38248763
PMID: 34834493
PMID: 32892962