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Finally out, our deep-dive into the molecular grammar of IDR-based transcription factor (TF) binding specificity. Looking for a TF IDR with malleable binding specificity we examined Gln3 and it did not disappoint. Have a look at this concise summary or academic.oup.com/nar/advance…
🎉Happy to share our new paper! Intrinsically disordered regions (IDRs) in transcription factors (TFs) encode for complex binding patterns using diverse sequence grammars and interaction types. (1/9)
academic.oup.com/nar/advance…
@bhurieva @Divya_KKumar guided by @FJonas15 @NaamaBarkai
Nice to see how yeast 🫶 can help us understand mammalian TF IDRs. Kudos to the Barkai lab for this elegant work. 🥳
How do transcription factors (TFs) that recognize the same DNA motif end up binding different places in the genome? 🧬
We're excited to show you how we tackle this question in our new bioRxiv pre-print!
doi.org/10.64898/2026.04.27.…
FJonas retweeted
(1/8) Still wondering how low complexity intrinsically disordered regions (IDRs) guide transcription factors (TFs) to bind in genomes? Previous studies on sequence grammars; our new @MolCell paper takes the next step: de novo design of functional TF IDRs!
cell.com/molecular-cell/full…
My recommended read for the weekend. Thanks for this inspiring commentary!
In @CellCellPress, I share a major conceptual challenge for biology in the next decade, inspired by Crick’s Central Dogma: understanding information flow in the cell, the smallest indivisible unit of life bit.ly/4hQMmva
FJonas retweeted
Paper alert:
Congratulations to PhD student, now Dr. Aryeh Solomon for this great work, published @eLife.
Can a BCG vaccine also protect from Gram-negative infection? #TrainedImmunity
Thanks also to long time collaborator Mihai Netea and other friends.
doi.org/10.7554/eLife.100922
Looking for an exciting science project ? My friend and colleague Sebastian Springer is offering a PhD position on the intersection between immunology and virology. Join is bustling lab and benefit from great mentorship and insight: drive.google.com/file/d/1pbu…
FJonas retweeted
Exciting news! Our latest paper "Ordered and disordered regions of the Origin Recognition Complex direct differential in vivo binding at distinct motif sequences", led by Michal Chappleboim is now out in @NAR_Open. Check out the highlights below.
doi.org/10.1093/nar/gkae249
FJonas retweeted
Finally out!!!
@MindelVladimir I was so lucky to work with you.
(1/13) Exciting findings from our latest study, now published in @NAR_Open as a breakthrough article! academic.oup.com/nar/advance…
I really like the simple model for Transcription Factor function: "DNA binding - Mediator recruitment - Gene activation." But this elegant and systematic study from
@MindelVladimir +@SagieBr, @BarkaiLab
provides an exciting fresh perspective. Highly recommended!
(1/13) Exciting findings from our latest study, now published in @NAR_Open as a breakthrough article! academic.oup.com/nar/advance…
FJonas retweeted
(1/13) Exciting findings from our latest study, now published in @NAR_Open as a breakthrough article! academic.oup.com/nar/advance…
Excited to learn more about TF binding in my second favorite yeast species:
A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin biorxiv.org/content/10.1101/…
Big kudos to @bhurieva and @Divya_KKumar for driving this comprehensive analysis!
And have a look at academic.oup.com/nar/article… for our first eamination of IDR grammar in Msn2
FJonas retweeted
🎉Happy to share our new paper! Intrinsically disordered regions (IDRs) in transcription factors (TFs) encode for complex binding patterns using diverse sequence grammars and interaction types. (1/9)
academic.oup.com/nar/advance…
@bhurieva @Divya_KKumar guided by @FJonas15 @NaamaBarkai
Join our Group ! We are looking for one PhD student to explore the "Molecular Basis of Transcription Factor Evolution". Find out more here and apply: drive.google.com/file/d/1nd_…
FJonas retweeted
Check out our new paper: “Intrinsically disordered regions of the Msn2 transcription factor encode multiple functions using interwoven sequence grammars” published @NAR_Open. The work of @MindelVladimir and @SagieBr. academic.oup.com/nar/advance…
FJonas retweeted
Great work by @handlerkristina !
New method to understand cell-cell communications | In a study published by @NatureComms, researchers from the Systems Physiology lab of Andreas Moor @moorlab, developed a method to characterise microenvironments at single-cell resolution > u.ethz.ch/Gm9Jg
FJonas retweeted
New preprint!
Engineered bacteria launch and control an oncolytic virus biorxiv.org/content/10.1101/…
Exciting work from @zsinger jpabon & lab engineering bacteria to deliver viral RNAs that launch viral spread. We also engineer the virus to depend on bacteria. Congrats all!
FJonas retweeted
Very excited to share our work and my first ever paper!🎉🎉
Super grateful to @voichek and many other people for making it happen
Take a look to read about our findings in the cell cycle status of developing gametes @PlantPhys
academic.oup.com/plphys/adva…
FJonas retweeted
Friends, Romans, Transcriptionmen, this is not to be missed. Free access live and online. October 10th @UNIGEnews
FJonas retweeted
Ever wondered how RNAPII navigates the 3D nuclear space to find gene targets? The C-terminal domain is its GPS! We've traced this incredible journey using single-molecule tracking, don't miss our findings! 🧬🛰️🔬biorxiv.org/content/10.1101/…